个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共24条记录   Ontogeny stage-independent and high-level clonal expansion in vitro of mouse hematopoietic stem cells stimulated by an engineered NUP98-HOX fusion transcription factor [作者：Sekulovic, S; Gasparetto, M; Lecault, V; Hoesli, CA; Kent, DG; Rosten, P; Wan, A; Brookes, C; Hansen, CL; Piret, JM; Smith, C; Eaves, CJ; Humphries, RK,期刊：Blood, 页码：4366-4376 , 文章类型： Article，,卷期：2011年118-16] Achieving high-level expansion of hematopoietic stem cells (HSCs) in vitro will have an important clinical impact in addition to enabling elucidation of their regulation. Here, we couple the ability of engineered NUP98-H... Impaired Fc epsilon RI stability, signaling, and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins [作者：Hazenbos, WLW; Wu, P; Eastham-Anderson, J; Kinoshita, T; Brown, EJ,期刊：Blood, 页码：4377-4383 , 文章类型： Article，,卷期：2011年118-16] A key event and potential therapeutic target in allergic and asthmatic diseases is signaling by the IgE receptor Fc epsilon RI, which depends on its interactions with Src family kinases (SFK). Here we tested the hypothes... Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia [作者：Clemente, MJ; Wlodarski, MW; Makishima, H; Viny, AD; Bretschneider, I; Shaik, M; Bejanyan, N; Lichtin, AE; His, ED; Paquette, RL; Loughran, TP; Maciejewski, JP,期刊：Blood, 页码：4384-4393 , 文章类型： Article，,卷期：2011年118-16] T-cell large granular lymphocyte leukemia (T-LGLL) is characterized by chronic lymphoproliferation of cytotoxic T lymphocytes (CTLs) and is associated with lineage-restricted cytopenias. Introduction of T-cell receptor (... Immunologic effects of rituximab on the human spleen in immune thrombocytopenia [作者：Audia, S; Samson, M; Guy, J; Janikashvili, N; Fraszczak, J; Trad, M; Ciudad, M; Leguy, V; Berthier, S; Petrella, T; Aho-Glele, S; Martin, L; Maynadie, M; Lorcerie, B; Rat, P; Cheynel, N; Katsanis, E; Larmonier, N; Bonnotte, B,期刊：Blood, 页码：4394-4400 , 文章类型： Article，,卷期：2011年118-16] Immune thrombocytopenia (ITP) is an autoimmune disease with a complex pathogenesis. As in many B cell-related autoimmune diseases, rituximab (RTX) has been shown to increase platelet counts in some ITP patients. From an ... ZAP-70 enhances migration of malignant B lymphocytes toward CCL21 by inducing CCR7 expression via IgM-ERK1/2 activation [作者：Calpe, E; Codony, C; Baptista, MJ; Abrisqueta, P; Carpio, C; Purroy, N; Bosch, F; Crespo, M,期刊：Blood, 页码：4401-4410 , 文章类型： Article，,卷期：2011年118-16] ZAP-70 in chronic lymphocytic leukemia (CLL) has been associated with enhanced B-cell receptor (BCR) signaling, survival, and migration. We investigated whether ZAP-70 can directly govern migration and the underlying mec... A novel inhibitor of focal adhesion signaling induces caspase-independent cell death in diffuse large B-cell lymphoma [作者：Bosch, R; Dieguez-Gonzalez, R; Cespedes, MV; Parreno, M; Pavon, MA; Granena, A; Sierra, J; Mangues, R; Casanova, I,期刊：Blood, 页码：4411-4420 , 文章类型： Article，,卷期：2011年118-16] Focal adhesion (FA) proteins have been associated with transformation, migration, metastasis, and poor outcome in many neoplasias. We previously showed that these proteins were inhibited by E7123, a new celecoxib derivat... Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic target [作者：Zappasodi, R; Bongarzone, I; Ghedini, GC; Castagnoli, L; Cabras, AD; Messina, A; Tortoreto, M; Tripodo, C; Magni, M; Carlo-Stella, C; Gianni, AM; Pupa, SM; Di Nicola, M,期刊：Blood, 页码：4421-4430 , 文章类型： Article，,卷期：2011年118-16] We reported that the clinical efficacy of dendritic cell-based vaccination is strongly associated with immunologic responses in relapsed B-cell non-Hodgkin lymphoma (B-NHL) patients. We have now investigated whether post... p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1 alpha-mediated down-regulation of CXCL12 [作者：Kojima, K; McQueen, T; Chen, Y; Jacamo, R; Konopleva, M; Shinojima, N; Shpall, E; Huang, XL; Andreeff, M,期刊：Blood, 页码：4431-4439 , 文章类型： Article，,卷期：2011年118-16] Fms-like tyrosine kinase-3 (FLT3) inhibitors have been used to overcome the dismal prognosis of acute myeloid leukemia (AML) with FLT3 mutations. Clinical results with FLT3 inhibitor monotherapy have shown that bone marr... Serglycin participates in retention of alpha-defensin in granules during myelopoiesis [作者：Glenthoj, A; Cowland, JB; Heegaard, NH; Larsen, MT; Borregaard, N,期刊：Blood, 页码：4440-4448 , 文章类型： Article，,卷期：2011年118-16] The mechanism by which proteins are targeted to neutrophil granules is largely unknown. The intracellular proteoglycan serglycin has been shown to have important functions related to storage of proteins in several types ... Brief report Extracellular matrix structure and nano-mechanics determine megakaryocyte function [作者：Malara, A; Gruppi, C; Pallotta, I; Spedden, E; Tenni, R; Raspanti, M; Kaplan, D; Tira, ME; Staii, C; Balduini, A,期刊：Blood, 页码：4449-4453 , 文章类型： Article，,卷期：2011年118-16] The iron hormone hepcidin is inhibited by matriptase-2 (MT2), a liver serine protease encoded by the TMPRSS6 gene. Cleaving the bone morphogenetic protein (BMP) coreceptor hemojuvelin (HJV), MT2 impairs the BMP/son of mo... KLF1 gene mutations cause borderline HbA(2) [作者：Perseu, L; Satta, S; Moi, P; Demartis, FR; Manunza, L; Sollaino, MC; Barella, S; Cao, A; Galanello, R,期刊：Blood, 页码：4454-4458 , 文章类型： Article，,卷期：2011年118-16] Increased hemoglobin A(2) (HbA(2); ie, levels > 3.9%) is the most important feature of beta-thalassemia carriers. However, it is not uncommon to find persons with borderline HbA(2) (levels, 3.3%-3.8%), who pose a relevan... TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals [作者：Nai, A; Pagani, A; Silvestri, L; Campostrini, N; Corbella, M; Girelli, D; Traglia, M; Toniolo, D; Camaschella, C,期刊：Blood, 页码：4459-4462 , 文章类型： Article，,卷期：2011年118-16] The iron hormone hepcidin is inhibited by matriptase-2 (MT2), a liver serine protease encoded by the TMPRSS6 gene. Cleaving the bone morphogenetic protein (BMP) coreceptor hemojuvelin (HJV), MT2 impairs the BMP/son of mo... Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen [作者：Lupu, C; Zhu, H; Popescu, NI; Wren, JD; Lupu, F,期刊：Blood, 页码：4463-4471 , 文章类型： Article，,卷期：2011年118-16] Thrombosis and cardiovascular disease (CVD) represent major causes of morbidity and mortality. Low androgen correlates with higher incidence of CVD/thrombosis. Tissue Factor Pathway Inhibitor (TFPI) is the major inhibito... Risk factors associated with increased nonrelapse mortality and with poor overall survival in children with chronic graft-versus-host disease [作者：Jacobsohn, DA; Arora, M; Klein, JP; Hassebroek, A; Flowers, ME; Cutler, CS; Urbano-Ispizua, A; Bolwell, BJ; Antin, JH; Boyiadzis, M; Cahn, JY; Cairo, MS; Herzig, RH; Isola, LM; Klumpp, TR; Lee, SJ; Petersdorf, EW; Santarone, S; Gale, RP; Schouten, HC; Spellman, SR; Weisdorf, DJ; Wingard, JR; Horowitz, MM; Pavletic, SZ,期刊：Blood, 页码：4472-4479 , 文章类型： Article，,卷期：2011年118-16] There is a paucity of information regarding the factors that affect nonrelapse mortality (NRM) and overall survival among children that develop chronic graft-versus-host disease (cGVHD). We performed multivariate analyse... CD8(+) T-cell reconstitution in recipients of umbilical cord blood transplantation and characteristics associated with leukemic relapse [作者：Merindol, N; Champagne, MA; Duval, M; Soudeyns, H,期刊：Blood, 页码：4480-4488 , 文章类型： Article，,卷期：2011年118-16] Recipients of umbilical cord blood (UCB) transplantation (UCBT) face a high risk of morbidity and mortality related to opportunistic infections (OI) and leukemic relapse. To understand the molecular basis of these UCBT-r... Defective ribosome assembly in Shwachman-Diamond syndrome [作者：Wong, CC; Traynor, D; Basse, N; Kay, RR; Warren, AJ,期刊：Blood, 页码：4305-4312 , 文章类型： Article，,卷期：2011年118-16] Shwachman-Diamond syndrome (SDS), a recessive leukemia predisposition disorder characterized by bone marrow failure, exocrine pancreatic insufficiency, skeletal abnormalities and poor growth, is caused by mutations in th...