- Driving Opposing Behaviors with Ensembles of Piriform Neurons
[作者：Choi, GB; Stettler, DD; Kallman, BR; Bhaskar, ST; Fleischmann, A; Axel, R,期刊：Cell, 页码：1003-1014 , 文章类型： Article，,卷期：2011年146-6]
- Anatomic and physiologic studies have suggested a model in which neurons of the piriform cortex receive convergent input from random collections of glomeruli. In this model, odor representations can only be afforded beha...
- Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
[作者：Tan, MJ; Luo, H; Lee, S; Jin, FL; Yang, JS; Montellier, E; Buchou, T; Cheng, ZY; Rousseaux, S; Rajagopal, N; Lu, ZK; Ye, Z; Zhu, Q; Wysocka, J; Ye, Y; Khochbin, S; Ren, B; Zhao, YM,期刊：Cell, 页码：1015-1027 , 文章类型： Article，,卷期：2011年146-6]
- We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), co...
- Sperm Methylation Profiles Reveal Features of Epigenetic Inheritance and Evolution in Primates
[作者：Molaro, A; Hodges, E; Fang, F; Song, Q; McCombie, WR; Hannon, GJ; Smith, AD,期刊：Cell, 页码：1028-1040 , 文章类型： Article，,卷期：2011年146-6]
- During germ cell and preimplantation development, mammalian cells undergo nearly complete reprogramming of DNA methylation patterns. We profiled the methylomes of human and chimp sperm as a basis for comparison to methyl...
- Molecular Mechanism of Protein Folding in the Cell
[作者：Rothman, JE; Schekman, R,期刊：Cell, 页码：851-854 , 文章类型： Editorial Material，,卷期：2011年146-6]
- F.-Ulrich Hartl and Arthur Horwich will share this year's Lasker Basic Medical Science Award for the discovery of the cell's protein-folding machinery, exemplified by cage-like structures that convert newly synthesized p...
- Artemisinin: Discovery from the Chinese Herbal Garden
[作者：Miller, LH; Su, XZ,期刊：Cell, 页码：855-858 , 文章类型： Editorial Material，,卷期：2011年146-6]
- This year's Lasker DeBakey Clinical Research Award goes to Youyou Tu for the discovery of artemisinin and its use in the treatment of malaria-a medical advance that has saved millions of lives across the globe, especiall...
- SIP-ing the Elixir of Youth
[作者：Mair, W; Steffen, KK; Dillin, A,期刊：Cell, 页码：859-860 , 文章类型： Editorial Material，,卷期：2011年146-6]
- AMP-activated protein kinase (AMPK) is a conserved cellular fuel gauge previously implicated in aging. In this issue, Lu et al. (2011) describe how age-related deacetylation of Sip2, a subunit of the AMPK homolog in yeas...
- A New Shield for a Cytokine Storm
[作者：Iwasaki, A; Medzhitov, R,期刊：Cell, 页码：861-862 , 文章类型： Editorial Material，,卷期：2011年146-6]
- Highly virulent influenza virus infection results in excessive cytokine production, recruitment of leukocytes, and immune-mediated pulmonary injury. Teijaro et al. (2011) now demonstrate that sphingosine-1-phosphate rece...
- DNA Demethylation Dynamics
[作者：Bhutani, N; Burns, DM; Blau, HM,期刊：Cell, 页码：866-872 , 文章类型： Article，,卷期：2011年146-6]
- The discovery of cytosine hydroxymethylation (5hmC) suggested a simple means of demethylating DNA and activating genes. Further experiments, however, unearthed an unexpectedly complex process, entailing both passive and ...
- Basic and Therapeutic Aspects of Angiogenesis
[作者：Potente, M; Gerhardt, H; Carmeliet, P,期刊：Cell, 页码：873-887 , 文章类型： Review，,卷期：2011年146-6]
- Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and they contribute to disease progression. ...
- Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements
[作者：Liu, PF; Erez, A; Nagamani, SCS; Dhar, SU; Kolodziejska, KE; Dharmadhikari, AV; Cooper, ML; Wiszniewska, J; Zhang, F; Withers, MA; Bacino, CA; Campos-Acevedo, LD; Delgado, MR; Freedenberg, D; Garnica, A; Grebe, TA; Hernandez-Almaguer, D; Immken, L; Lalani, SR; McLean, SD; Northrup, H; Scaglia, F; Strathearn, L; Trapane, P; Kang, SHL; Patel, A; Cheung, SW; Hastings, PJ; Stankiewicz, P; Lupski, JR; Bi, WM,期刊：Cell, 页码：888-902 , 文章类型： Article，,卷期：2011年146-6]
- Complex genomic rearrangements (CGRs) consisting of two or more breakpoint junctions have been observed in genomic disorders. Recently, a chromosome catastrophe phenomenon termed chromothripsis, in which numerous genomic...
- BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
[作者：Delmore, JE; Issa, GC; Lemieux, ME; Rahl, PB; Shi, JW; Jacobs, HM; Kastritis, E; Gilpatrick, T; Paranal, RM; Qi, J; Chesi, M; Schinzel, AC; McKeown, MR; Heffernan, TP; Vakoc, CR; Bergsagel, PL; Ghobrial, IM; Richardson, PG; Young, RA; Hahn, WC; Anderson, KC; Kung, AL; Bradner, JE; Mitsiades, CS,期刊：Cell, 页码：903-916 , 文章类型： Article，,卷期：2011年146-6]
- MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to modulate the function of the c-Myc oncoprotein do not exist. Toward this objective, we have targeted MYC transcription by interfering ...
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