- Is iNOS Beginning to Smoke?
[作者：Nathan, C,期刊：Cell, 页码：257-258 , 文章类型： Editorial Material，,卷期：2011年147-2]
- Inducible nitric oxide synthase (iNOS) helps drive numerous inflammatory disorders, but its inhibition has not had therapeutic success. Now Seimetz et al. (2011) make a case for inhibiting iNOS in an effort to treat one ...
- Why Does Morphine Make You Itch?
[作者：Miyamoto, T; Patapoutian, A,期刊：Cell, 页码：261-262 , 文章类型： Editorial Material，,卷期：2011年147-2]
- Opioids such as morphine numb pain but often concomitantly induce itch. Liu et al. (2011) now separate the sensation of itch from opioid-induced analgesia, showing that in a subset of spinal neurons, morphine directly in...
- Genome-wide "Re"-Modeling of Nucleosome Positions
[作者：Sadeh, R; Allis, CD,期刊：Cell, 页码：263-266 , 文章类型： Review，,卷期：2011年147-2]
- Two recent studies mapped nucleosomes across the yeast and human genomes, teasing apart the relative contributions of DNA sequence and chromatin remodelers to nucleosome organization. These data suggest two emerging mode...
- The Impressionistic Landscape of Meiotic Recombination
[作者：Lichten, M; de Massy, B,期刊：Cell, 页码：267-270 , 文章类型： Review，,卷期：2011年147-2]
- Two high-resolution maps of meiotic recombination initiation sites across the genomes of budding yeast and mice illuminate broad similarities in the control of meiotic recombination in these diverse species but also high...
- Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice
[作者：Seimetz, M; Parajuli, N; Pichl, A; Veit, F; Kwapiszewska, G; Weisel, FC; Milger, K; Egemnazarov, B; Turowska, A; Fuchs, B; Nikam, S; Roth, M; Sydykov, A; Medebach, T; Klepetko, W; Jaksch, P; Dumitrascu, R; Garn, H; Voswinckel, R; Kostin, S; Seeger, W; Schermuly, RT; Grimminger, F; Ghofrani, HA; Weissmann, N,期刊：Cell, 页码：293-305 , 文章类型： Article，,卷期：2011年147-2]
- Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death worldwide. We report in an emphysema model of mice chronically exposed to tobacco smoke that pulmonary vascular dysfunction, vascular...
- Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis
[作者：Grebien, F; Hantschel, O; Wojcik, J; Kaupe, I; Kovacic, B; Wyrzucki, AM; Gish, GD; Cerny-Reiterer, S; Koide, A; Beug, H; Pawson, T; Valent, P; Koide, S; Superti-Furga, G,期刊：Cell, 页码：306-319 , 文章类型： Article，,卷期：2011年147-2]
- Chronic myelogenous leukemia (CML) is caused by the constitutively active tyrosine kinase Bcr-Abl and treated with the tyrosine kinase inhibitor (TKI) imatinib. However, emerging TKI resistance prevents complete cure. Th...
- Introns within Ribosomal Protein Genes Regulate the Production and Function of Yeast Ribosomes
[作者：Parenteau, J; Durand, M; Morin, G; Gagnon, J; Lucier, JF; Wellinger, RJ; Chabot, B; Abou Elela, S,期刊：Cell, 页码：320-331 , 文章类型： Article，,卷期：2011年147-2]
- In budding yeast, the most abundantly spliced pre-mRNAs encode ribosomal proteins (RPs). To investigate the contribution of splicing to ribosome production and function, we systematically eliminated introns from all RP g...
- Two Forms of Loops Generate the Chromatin Conformation of the Immunoglobulin Heavy-Chain Gene Locus
[作者：Guo, CY; Gerasimova, T; Hao, HP; Ivanova, I; Chakraborty, T; Selimyan, R; Oltz, EM; Sen, RJ,期刊：Cell, 页码：332-343 , 文章类型： Article，,卷期：2011年147-2]
- The immunoglobulin heavy-chain (IgH) gene locus undergoes radial repositioning within the nucleus and locus contraction in preparation for gene recombination. We demonstrate that IgH locus conformation involves two level...
- Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs
[作者：Tay, Y; Kats, L; Salmena, L; Weiss, D; Tan, SM; Ala, U; Karreth, F; Poliseno, L; Provero, P; Di Cunto, F; Lieberman, J; Rigoutsos, I; Pandolfi, PP,期刊：Cell, 页码：344-357 , 文章类型： Article，,卷期：2011年147-2]
- Here, we demonstrate that protein-coding RNA transcripts can crosstalk by competing for common microRNAs, with microRNA response elements as the foundation of this interaction. We have termed such RNA transcripts as comp...
- A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
[作者：Cesana, M; Cacchiarelli, D; Legnini, I; Santini, T; Sthandier, O; Chinappi, M; Tramontano, A; Bozzoni, I,期刊：Cell, 页码：358-369 , 文章类型： Article，,卷期：2011年147-2]
- Recently, a new regulatory circuitry has been identified in which RNAs can crosstalk with each other by competing for shared microRNAs. Such competing endogenous RNAs (ceRNAs) regulate the distribution of miRNA molecules...
- An Extensive MicroRNA-Mediated Network of RNA-RNA Interactions Regulates Established Oncogenic Pathways in Glioblastoma
[作者：Sumazin, P; Yang, XR; Chiu, HS; Chung, WJ; Iyer, A; Llobet-Navas, D; Rajbhandari, P; Bansal, M; Guarnieri, P; Silva, J; Califano, A,期刊：Cell, 页码：370-381 , 文章类型： Article，,卷期：2011年147-2]
- By analyzing gene expression data in glioblastoma in combination with matched microRNA profiles, we have uncovered a posttranscriptional regulation layer of surprising magnitude, comprising more than 248,000 microRNA (mi...
- In Vivo Identification of Tumor-Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma
[作者：Karreth, FA; Tay, Y; Perna, D; Ala, U; Tan, SM; Rust, AG; DeNicola, G; Webster, KA; Weiss, D; Perez-Mancera, PA; Krauthammer, M; Halaban, R; Provero, P; Adams, DJ; Tuveson, DA; Pandolfi, PP,期刊：Cell, 页码：382-395 , 文章类型： Article，,卷期：2011年147-2]
- We recently proposed that competitive endogenous RNAs (ceRNAs) sequester microRNAs to regulate mRNA transcripts containing common microRNA recognition elements (MREs). However, the functional role of ceRNAs in cancer rem...
|