- Derepressing Nuclear Receptors for Metabolic Adaptation
[作者：Saltiel, AR,期刊：Cell, 页码：717-718 , 文章类型： Editorial Material，,卷期：2011年147-4]
- NCoR is a corepressor of several transcription factors, including the PPAR family of nuclear receptors in fat and muscle. By specifically deleting NCoR in these tissues, Li et al. and Yamamoto et al. now uncover an impor...
- New Driver for Lipid Synthesis
[作者：Houten, SM; Argmann, CA,期刊：Cell, 页码：719-721 , 文章类型： Editorial Material，,卷期：2011年147-4]
- Cholesterol regulates activation of sterol regulatory element-binding protein (SREBP) through a classic feedback loop. Walker et al. (2011) extend the regulatory inputs governing SREBP activity to include an independent ...
- PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic
[作者：Kane, LA; Youle, RJ,期刊：Cell, 页码：721-723 , 文章类型： Editorial Material，,卷期：2011年147-4]
- The Parkinson's disease proteins PINK1 and Parkin are proposed guardians of mitochondrial fidelity, targeting damaged mitochondria for degradation by mitophagy. In this issue of Cell, Wang et al. (2011) now show that PIN...
- Feedback on Fat: p62-mTORC1-Autophagy Connections
[作者：Moscat, J; Diaz-Meco, MT,期刊：Cell, 页码：724-727 , 文章类型： Review，,卷期：2011年147-4]
- Metabolic homeostasis requires integration of multiple signals and cellular activities. Without this integration, conditions of obesity and diabetes often develop. Recent in vivo studies explore the molecular basis for m...
- Autophagy: Renovation of Cells and Tissues
[作者：Mizushima, N; Komatsu, M,期刊：Cell, 页码：728-741 , 文章类型： Review，,卷期：2011年147-4]
- Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the lysosome. However, the purpose of autophagy is not the simple elimination of materials, but inst...
- Programmed Cell Death in Animal Development and Disease
[作者：Fuchs, Y; Steller, H,期刊：Cell, 页码：742-758 , 文章类型： Review，,卷期：2011年147-4]
- Programmed cell death (PCD) plays a fundamental role in animal development and tissue homeostasis. Abnormal regulation of this process is associated with a wide variety of human diseases, including immunological and deve...
- The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells
[作者：Cordenonsi, M; Zanconato, F; Azzolin, L; Forcato, M; Rosato, A; Frasson, C; Inui, M; Montagner, M; Parenti, AR; Poletti, A; Daidone, MG; Dupont, S; Basso, G; Bicciato, S; Piccolo, S,期刊：Cell, 页码：759-772 , 文章类型： Article，,卷期：2011年147-4]
- Cancer stem cells (CSCs) are proposed to drive tumor initiation and progression. Yet, our understanding of the cellular and molecular mechanisms that underlie CSC properties is limited. Here we show that the activity of ...
- ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs
[作者：Yang, LQ; Lin, CR; Liu, W; Zhang, J; Ohgi, KA; Grinstein, JD; Dorrestein, PC; Rosenfeld, MG,期刊：Cell, 页码：773-788 , 文章类型： Article，,卷期：2011年147-4]
- Although eukaryotic nuclei contain distinct architectural structures associated with noncoding RNAs (ncRNAs), their potential relationship to regulated transcriptional programs remains poorly understood. Here, we report ...
- Adipocyte NCoR Knockout Decreases PPAR gamma Phosphorylation and Enhances PPAR gamma Activity and Insulin Sensitivity
[作者：Li, PP; Fan, WQ; Xu, JF; Lu, M; Yamamoto, H; Auwerx, J; Sears, DD; Talukdar, S; Oh, D; Chen, A; Bandyopadhyay, G; Scadeng, M; Ofrecio, JM; Nalbandian, S; Olefsky, JM,期刊：Cell, 页码：815-826 , 文章类型： Article，,卷期：2011年147-4]
- Insulin resistance, tissue inflammation, and adipose tissue dysfunction are features of obesity and Type 2 diabetes. We generated adipocyte-specific Nuclear Receptor Corepressor (NCoR) knockout (AKO) mice to investigate ...
- NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function
[作者：Yamamoto, H; Williams, EG; Mouchiroud, L; Canto, C; Fan, WW; Downes, M; Heligon, C; Barish, GD; Desvergne, B; Evans, RM; Schoonjans, K; Auwerx, J,期刊：Cell, 页码：827-839 , 文章类型： Article，,卷期：2011年147-4]
- Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We show here that muscle-specific loss of nuclear receptor corepre...
- A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans
[作者：Walker, AK; Jacobs, RL; Watts, JL; Rottiers, V; Jiang, K; Finnegan, DM; Shioda, T; Hansen, M; Yang, F; Niebergall, LJ; Vance, DE; Tzoneva, M; Hart, AC; Naar, AM,期刊：Cell, 页码：840-852 , 文章类型： Article，,卷期：2011年147-4]
- Sterol regulatory element-binding proteins (SREBPs) activate genes involved in the synthesis and trafficking of cholesterol and other lipids and are critical for maintaining lipid homeostasis. Aberrant SREBP activity, ho...
- Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits
[作者：Chevrier, N; Mertins, P; Artyomov, MN; Shalek, AK; Iannacone, M; Ciaccio, MF; Gat-Viks, I; Tonti, E; DeGrace, MM; Clauser, KR; Garber, M; Eisenhaure, TM; Yosef, N; Robinson, J; Sutton, A; Andersen, MS; Root, DE; von Andrian, U; Jones, RB; Park, H; Carr, SA; Regev, A; Amit, I; Hacohen, N,期刊：Cell, 页码：853-867 , 文章类型： Article，,卷期：2011年147-4]
- Deciphering the signaling networks that underlie normal and disease processes remains a major challenge. Here, we report the discovery of signaling components involved in the Toll-like receptor (TLR) response of immune d...
- CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4
[作者：Zanoni, I; Ostuni, R; Marek, LR; Barresi, S; Barbalat, R; Barton, GM; Granucci, F; Kagan, JC,期刊：Cell, 页码：868-880 , 文章类型： Article，,卷期：2011年147-4]
- The transport of Toll-like Receptors (TLRs) to various organelles has emerged as an essential means by which innate immunity is regulated. While most of our knowledge is restricted to regulators that promote the transpor...
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