- Glioma Development: Where Did It All Go Wrong?
[作者：Sukhdeo, K; Hambardzumyan, D; Rich, JN,期刊：Cell, 页码：187-188 , 文章类型： Editorial Material，,卷期：2011年146-2]
- Investigating the family tree of a tumor to identify its cellular origins is a daunting task. Liu et al. (2011) now use an elegant lineage tracing technique (MADM) to visualize glioma from its earliest stages. They show ...
- Tethered Genes Get Checked during Replication
[作者：Lukas, J; Bartek, J,期刊：Cell, 页码：189-191 , 文章类型： Editorial Material，,卷期：2011年146-2]
- Although events associated with replication stress have long formed the cornerstone of checkpoint activation, questions remain about how cells maintain the integrity of replicating genomes. Now, Bermejo et al. (2011) ide...
- Nuclear Pore Structure: Warming up theCore
[作者：Harel, A; Gruenbaum, Y,期刊：Cell, 页码：191-193 , 文章类型： Editorial Material，,卷期：2011年146-2]
- Structural determination of the nuclear pore complex has been limited by the complexity and size of this cellular megalith. By taking advantage of exceptionally stable nucleoporins from the thermophilic fungus Chaetomium...
- Genetics of Sleep and Sleep Disorders
[作者：Sehgal, A; Mignot, E,期刊：Cell, 页码：194-207 , 文章类型： Review，,卷期：2011年146-2]
- Sleep remains one of the least understood phenomena in biology-even its role in synaptic plasticity remains debatable. Since sleep was recognized to be regulated genetically, intense research has launched on two fronts: ...
- Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma
[作者：Liu, C; Sage, JC; Miller, MR; Verhaak, RGW; Hippenmeyer, S; Vogel, H; Foreman, O; Bronson, RT; Nishiyama, A; Luo, LQ; Zong, H,期刊：Cell, 页码：209-221 , 文章类型： Article，,卷期：2011年146-2]
- Cancer cell of origin is difficult to identify by analyzing cells within terminal stage tumors, whose identity could be concealed by the acquired plasticity. Thus, an ideal approach to identify the cell of origin is to a...
- SSB Functions as a Sliding Platform that Migrates on DNA via Reptation
[作者：Zhou, RB; Kozlov, AG; Roy, R; Zhang, JC; Korolev, S; Lohman, TM; Ha, T,期刊：Cell, 页码：222-232 , 文章类型： Article，,卷期：2011年146-2]
- SSB proteins bind to and control the accessibility of single-stranded DNA (ssDNA), likely facilitated by their ability to diffuse on ssDNA. Using a hybrid single-molecule method combining fluorescence and force, we probe...
- The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores
[作者：Bermejo, R; Capra, T; Jossen, R; Colosio, A; Frattini, C; Carotenuto, W; Cocito, A; Doksani, Y; Klein, H; Gomez-Gonzalez, B; Aguilera, A; Katou, Y; Shirahige, K; Foiani, M,期刊：Cell, 页码：233-246 , 文章类型： Article，,卷期：2011年146-2]
- Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. Examining checkpoint-dependent mechanisms controlling fork stability, we find that fork reversal and ...
- FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
[作者：Darnell, JC; Van Driesche, SJ; Zhang, CL; Hung, KYS; Mele, A; Fraser, CE; Stone, EF; Chen, C; Fak, JJ; Chi, SW; Licatalosi, DD; Richter, JD; Darnell, RB,期刊：Cell, 页码：247-261 , 文章类型： Article，,卷期：2011年146-2]
- FMRP loss of function causes Fragile X syndrome (FXS) and autistic features. FMRP is a polyribosome-associated neuronal RNA-binding protein, suggesting that it plays a key role in regulating neuronal translation, but the...
- The Inside-Out Mechanism of Dicers from Budding Yeasts
[作者：Weinberg, DE; Nakanishi, K; Patel, DJ; Bartel, DP,期刊：Cell, 页码：262-276 , 文章类型： Article，,卷期：2011年146-2]
- The Dicer ribonuclease III (RNase III) enzymes process long double-stranded RNA (dsRNA) into small interfering RNAs (siRNAs) that direct RNA interference. Here, we describe the structure and activity of a catalytically a...
- Insight into Structure and Assembly of the Nuclear Pore Complex by Utilizing the Genome of a Eukaryotic Thermophile
[作者：Amlacher, S; Sarges, P; Flemming, D; van Noort, V; Kunze, R; Devos, DP; Arumugam, M; Bork, P; Hurt, E,期刊：Cell, 页码：277-289 , 文章类型： Article，,卷期：2011年146-2]
- Despite decades of research, the structure and assembly of the nuclear pore complex (NPC), which is composed of similar to 30 nucleoporins (Nups), remain elusive. Here, we report the genome of the thermophilic fungus Cha...
- SNARE Proteins Are Required for Macroautophagy
[作者：Nair, U; Jotwani, A; Geng, JF; Gammoh, N; Richerson, D; Yen, WL; Griffith, J; Nag, S; Wang, K; Moss, T; Baba, M; Mcnew, JA; Jiang, XJ; Reggiori, F; Melia, TJ; Klionsky, DJ,期刊：Cell, 页码：290-302 , 文章类型： Article，,卷期：2011年146-2]
- Macroautophagy mediates the degradation of long-lived proteins and organelles via the de novo formation of double-membrane autophagosomes that sequester cytoplasm and deliver it to the vacuole/lysosome; however, relative...
- Autophagosome Precursor Maturation Requires Homotypic Fusion
[作者：Moreau, K; Ravikumar, B; Renna, M; Puri, C; Rubinsztein, DC,期刊：Cell, 页码：303-317 , 文章类型： Article，,卷期：2011年146-2]
- Autophagy is a catabolic process in which lysosomes degrade intracytoplasmic contents transported in double-membraned autophagosomes. Autophagosomes are formed by the elongation and fusion of phagophores, which can be de...
- Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations
[作者：Soldner, F; Laganiere, J; Cheng, AW; Hockemeyer, D; Gao, Q; Alagappan, R; Khurana, V; Golbe, LI; Myers, RH; Lindquist, S; Zhang, L; Guschin, D; Fong, LK; Vu, BJ; Meng, XD; Urnov, FD; Rebar, EJ; Gregory, PD; Zhang, HS; Jaenisch, R,期刊：Cell, 页码：318-331 , 文章类型： Article，,卷期：2011年146-2]
- Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising source for cell replacement therapies. One crucial limitatio...
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