- Privileged Signaling for Brain Growth
[作者：Teleman, AA,期刊：Cell, 页码：346-347 , 文章类型： Editorial Material，,卷期：2011年146-3]
- When developing animals encounter nutrient restriction, most tissues stop growing. Some vital tissues, however, such as the brain, continue to grow. Now, Cheng et al. (2011) identify Alk as the kinase that allows the Dro...
- A Prion-like Trigger of Antiviral Signaling
[作者：Ye, JQ; Maniatis, T,期刊：Cell, 页码：348-350 , 文章类型： Editorial Material，,卷期：2011年146-3]
- The MAVS protein plays a critical role in the assembly of an antiviral signaling complex on mitochondrial membranes. Hou et al. (2011) now report that virus infection induces a conformational change in MAVS, leading to t...
- Regulatory Revolution: Evolving the "Anti-LacI" Repressor
[作者：Marx, CJ,期刊：Cell, 页码：350-352 , 文章类型： Editorial Material，,卷期：2011年146-3]
- Much of adaptation is based upon changes in gene expression, but the emergence of new regulatory logic has not been observed directly. Now, Poelwijk et al. report evolving the lac repressor (LacI) to reverse its regulato...
- A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
[作者：Salmena, L; Poliseno, L; Tay, Y; Kats, L; Pandolfi, PP,期刊：Cell, 页码：353-358 , 文章类型： Article，,卷期：2011年146-3]
- Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that...
- Directed Conversion of Alzheimer's Disease Patient Skin Fibroblasts into Functional Neurons
[作者：Qiang, L; Fujita, R; Yamashita, T; Angulo, S; Rhinn, H; Rhee, D; Doege, C; Chau, L; Aubry, L; Vanti, WB; Moreno, H; Abeliovich, A,期刊：Cell, 页码：359-371 , 文章类型： Article，,卷期：2011年146-3]
- Directed conversion of mature human cells, as from fibroblasts to neurons, is of potential clinical utility for neurological disease modeling as well as cell therapeutics. Here, we describe the efficient generation of hu...
- Spo11-Accessory Proteins Link Double-Strand Break Sites to the Chromosome Axis in Early Meiotic Recombination
[作者：Panizza, S; Mendoza, MA; Berlinger, M; Huang, LZ; Nicolas, A; Shirahige, K; Klein, F,期刊：Cell, 页码：372-383 , 文章类型： Article，,卷期：2011年146-3]
- Meiotic recombination between homologous chromosomes initiates via programmed DNA double-strand breaks (DSBs), generated by complexes comprising Spo11 transesterase plus accessory proteins. DSBs arise concomitantly with ...
- Structure of a Key Intermediate of the SMN Complex Reveals Gemin2's Crucial Function in snRNP Assembly
[作者：Zhang, RD; So, BR; Li, PL; Yong, J; Glisovic, T; Wan, LL; Dreyfuss, G,期刊：Cell, 页码：384-395 , 文章类型： Article，,卷期：2011年146-3]
- The SMN complex mediates the assembly of heptameric Sm protein rings on small nuclear RNAs (snRNAs), which are essential for snRNP function. Specific Sm core assembly depends on Sm proteins and snRNA recognition by SMN/G...
- The Min Oscillator Uses MinD-Dependent Conformational Changes in MinE to Spatially Regulate Cytokinesis
[作者：Park, KT; Wu, W; Battaile, KP; Lovell, S; Holyoak, T; Lutkenhaus, J,期刊：Cell, 页码：396-407 , 文章类型： Article，,卷期：2011年146-3]
- In E. coli, MinD recruits MinE to the membrane, leading to a coupled oscillation required for spatial regulation of the cytokinetic Z ring. How these proteins interact, however, is not clear because the MinD-binding regi...
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
[作者：Peterson, TR; Sengupta, SS; Harris, TE; Carmack, AE; Kang, SA; Balderas, E; Guertin, DA; Madden, KL; Carpenter, AE; Finck, BN; Sabatini, DM,期刊：Cell, 页码：408-420 , 文章类型： Article，,卷期：2011年146-3]
- The nutrient-and growth factor-responsive kinase mTOR complex 1 (mTORC1) regulates many processes that control growth, including protein synthesis, autophagy, and lipogenesis. Through unknown mechanisms, mTORC1 promotes ...
- Recruitment of Actin Modifiers to TrkA Endosomes Governs Retrograde NGF Signaling and Survival
[作者：Harrington, AW; St Hillaire, C; Zweifel, LS; Glebova, NO; Philippidou, P; Halegoua, S; Ginty, DD,期刊：Cell, 页码：421-434 , 文章类型： Article，,卷期：2011年146-3]
- The neurotrophins NGF and NT3 collaborate to support development of sympathetic neurons. Although both promote axonal extension via the TrkA receptor, only NGF activates retrograde transport of TrkA endosomes to support ...
- Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila
[作者：Cheng, LY; Bailey, AP; Leevers, SJ; Ragan, TJ; Driscoll, PC; Gould, AP,期刊：Cell, 页码：435-447 , 文章类型： Article，,卷期：2011年146-3]
- Developing animals survive periods of starvation by protecting the growth of critical organs at the expense of other tissues. Here, we use Drosophila to explore the as yet unknown mechanisms regulating this privileged ti...
- MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response
[作者：Hou, FJ; Sun, LJ; Zheng, H; Skaug, B; Jiang, QX; Chen, ZJJ,期刊：Cell, 页码：448-461 , 文章类型： Article，,卷期：2011年146-3]
- In response to viral infection, RIG-I-like RNA helicases bind to viral RNA and activate the mitochondrial protein MAVS, which in turn activates the transcription factors IRF3 and NF-kappa B to induce type I interferons. ...
- Tradeoffs and Optimality in the Evolution of Gene Regulation
[作者：Poelwijk, FJ; de Vos, MGJ; Tans, SJ,期刊：Cell, 页码：462-470 , 文章类型： Article，,卷期：2011年146-3]
- Cellular regulation is believed to evolve in response to environmental variability. However, this has been difficult to test directly. Here, we show that a gene regulation system evolves to the optimal regulatory respons...
- Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition
[作者：von Kleist, L; Stahlschmidt, W; Bulut, H; Gromova, K; Puchkov, D; Robertson, MJ; MacGregor, KA; Tomlin, N; Pechstein, A; Chau, N; Chircop, M; Sakoff, J; von Kries, JP; Saenger, W; Krausslich, HG; Shupliakov, O; Robinson, PJ; McCluskey, A; Haucke, V,期刊：Cell, 页码：471-484 , 文章类型： Article，,卷期：2011年146-3]
- Clathrin-mediated endocytosis (CME) regulates many cell physiological processes such as the internalization of growth factors and receptors, entry of pathogens, and synaptic transmission. Within the endocytic network, cl...
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