- Regulatory BCL2 promoter polymorphism (-938C > A) is associated with adverse outcome in patients with prostate carcinoma
[作者:Bachmann, HS; Heukamp, LC; Schmitz, KJ; Hilburn, CF; Kahl, P; Buettner, R; Nuckel, H; Eisenhardt, A; Rubben, H; Schmid, KW; Siffert, W; Eggert, A; Schramm, A; Schulte, JH,期刊:International Journal of Cancer, 页码:2390-2399 , 文章类型: Article,,卷期:2011年129-10]
- Molecular markers predictive of prostate cancer prognosis are urgently needed. Overexpression of the antiapoptotic protein, Bcl-2, has repeatedly been shown to be associated with adverse outcome in this malignancy. We hy...
- Genome-wide linkage scan for prostate cancer susceptibility in Finland: evidence for a novel locus on 2q37.3 and confirmation of signal on 17q21-q22
[作者:Cropp, CD; Simpson, CL; Wahlfors, T; Ha, N; George, A; Jones, MS; Harper, U; Ponciano-Jackson, D; Green, TA; Tammela, TLJ; Bailey-Wilson, J; Schleutker, J,期刊:International Journal of Cancer, 页码:2400-2407 , 文章类型: Article,,卷期:2011年129-10]
- Genome-wide linkage studies have been used to localize rare and highly penetrant prostate cancer (PRCA) susceptibility genes. Linkage studies performed in different ethnic backgrounds and populations have been somewhat d...
- Lapatinib inhibits receptor phosphorylation and cell growth and enhances antibody-dependent cellular cytotoxicity of EGFR- and HER2-overexpressing esophageal cancer cell lines
[作者:Mimura, K; Kono, K; Maruyama, T; Watanabe, M; Izawa, S; Shiba, S; Mizukami, Y; Kawaguchi, Y; Inoue, M; Kono, T; Choudhury, A; Kiessling, R; Fujii, H,期刊:International Journal of Cancer, 页码:2408-2416 , 文章类型: Article,,卷期:2011年129-10]
- Lapatinib is a dual tyrosine kinase inhibitor of the EGFR and HER2 tyrosine kinase domains. EGFR is expressed in 33.3% and HER2 in 30.3% of esophageal squamous cell carcinomas (ESCCs). To explore the potential utility of...
- CD103 is a hallmark of tumor-infiltrating regulatory T cells
[作者:Anz, D; Mueller, W; Golic, M; Kunz, WG; Rapp, M; Koelzer, VH; Ellermeier, J; Ellwart, JW; Schnurr, M; Bourquin, C; Endres, S,期刊:International Journal of Cancer, 页码:2417-2426 , 文章类型: Article,,卷期:2011年129-10]
- Regulatory T cells (Treg) mediate tolerance towards self-antigens by suppression of innate and adaptive immunity. In cancer patients, tumor-infiltrating FoxP3+ Treg suppress local anti-tumor immune responses and are ofte...
- A MAGE-C2 antigenic peptide processed by the immunoproteasome is recognized by cytolytic T cells isolated from a melanoma patient after successful immunotherapy
[作者:Ma, WB; Vigneron, N; Chapiro, J; Stroobant, V; Germeau, C; Boon, T; Coulie, PG; Van den Eynde, BJ,期刊:International Journal of Cancer, 页码:2427-2434 , 文章类型: Article,,卷期:2011年129-10]
- We have pursued our analysis of a melanoma patient who showed almost complete tumor regression following vaccination with MAGE-A1 and MAGE-A3 antigens. We previously described high frequencies of tumor-specific CTL precu...
- Molecular markers of endometrial carcinoma detected in uterine aspirates
[作者:Colas, E; Perez, C; Cabrera, S; Pedrola, N; Monge, M; Castellvi, J; Eyzaguirre, F; Gregorio, J; Ruiz, A; Llaurado, M; Rigau, M; Garcia, M; Ertekin, T; Montes, M; Lopez-Lopez, R; Carreras, R; Xercavins, J; Ortega, A; Maes, T; Rosell, E; Doll, A; Abal, M; Reventos, J; Gil-Moreno, A,期刊:International Journal of Cancer, 页码:2435-2444 , 文章类型: Article,,卷期:2011年129-10]
- Endometrial cancer (EC) is the most frequent of the invasive tumors of the female genital tract. Although usually detected in its initial stages, a 20% of the patients present with advanced disease. To date, no character...
- Leukemia stem cells
[作者:Buss, EC; Ho, AD,期刊:International Journal of Cancer, 页码:2328-2336 , 文章类型: Article,,卷期:2011年129-10]
- Leukemia stem cells (LSCs) might originate from malignant transformation of normal hematopoietic stem cells (HSCs), or alternatively, of progenitors in which the acquired mutations have re-installed a dysregulated self-r...
- Glutamate increases pancreatic cancer cell invasion and migration via AMPA receptor activation and Kras-MAPK signaling
[作者:Herner, A; Sauliunaite, D; Michalski, CW; Erkan, M; De Oliveira, T; Abiatari, I; Kong, B; Esposito, I; Friess, H; Kleeff, J,期刊:International Journal of Cancer, 页码:2349-2359 , 文章类型: Article,,卷期:2011年129-10]
- Glutamate has been implicated in tumorigenesis through activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR). However, the function of a glutamate-to-AMPAR signal in pancreatic d...
- IGFBP-4 activates the Wnt/beta-catenin signaling pathway and induces M-CAM expression in human renal cell carcinoma
[作者:Ueno, K; Hirata, H; Majid, S; Tabatabai, ZL; Hinoda, Y; Dahiya, R,期刊:International Journal of Cancer, 页码:2360-2369 , 文章类型: Article,,卷期:2011年129-10]
- The Wnt/beta-catenin signaling pathway is inactivated by Wnt antagonists in most cancers and IGFBP-4 is an antagonist of the Wnt/beta-catenin signaling pathway. However, the function of IGFBP-4 is not currently understoo...
- Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma
[作者:Bobola, MS; Jankowski, PP; Gross, ME; Schwartz, J; Finn, LS; Blank, A; Ellenbogen, RG; Silber, JR,期刊:International Journal of Cancer, 页码:2370-2379 , 文章类型: Article,,卷期:2011年129-10]
- Apurinic/apyrimidinic endonuclease (Ap endo) is a key DNA repair activity that confers radiation resistance in human cells. Here we examined the association between Ap endo activity and response to radiotherapy in pediat...
- High expression of stratifin is a universal abnormality during the course of malignant progression of early-stage lung adenocarcinoma
[作者:Shiba-Ishii, A; Kano, J; Morishita, Y; Sato, Y; Minami, Y; Noguchi, M,期刊:International Journal of Cancer, 页码:2445-2453 , 文章类型: Article,,卷期:2011年129-10]
- Adenocarcinoma in situ (AIS) of the lung has an extremely favorable prognosis, with a 5-year survival rate of 100%. However, early invasive adenocarcinoma (EIA) often has a fatal outcome. In this study, we compared the e...
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