- Folic acid and prevention of colorectal adenomas: a combined analysis of randomized clinical trials
[作者:Figueiredo, JC; Mott, LA; Giovannucci, E; Wu, KN; Cole, B; Grainge, MJ; Logan, RF; Baron, JA,期刊:International Journal of Cancer, 页码:192-203 , 文章类型: Article,,卷期:2011年129-1]
- Observational data suggest that lower folate status is associated with an increased risk of colorectal neoplasia, implying that folate may be useful as a chemopreventive agent. We conducted a combined analysis of three l...
- The novel histone deacetylase inhibitor, AR-42, inhibits gp130/Stat3 pathway and induces apoptosis and cell cycle arrest in multiple myeloma cells
[作者:Zhang, SH; Suvannasankha, A; Crean, CD; White, VL; Chen, CS; Farag, SS,期刊:International Journal of Cancer, 页码:204-213 , 文章类型: Article,,卷期:2011年129-1]
- Multiple myeloma (MM) remains incurable with current therapy, indicating the need for continued development of novel therapeutic agents. We evaluated the activity of a novel phenylbutyrate-derived histone deacetylase inh...
- MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation
[作者:Zhang, ZX; Meng, T; Yang, N; Wang, W; Xiong, B; Chen, Y; Ma, LP; Shen, JK; Miao, ZH; Ding, J,期刊:International Journal of Cancer, 页码:214-224 , 文章类型: Article,,卷期:2011年129-1]
- Microtubule-targeted drugs are now indispensable for the therapy of various cancer types worldwide. In this article, we report MT119 [6-[2-(4-methoxyphenyl) -ethyl]-9-[(pyridine-3-ylmethyl)amino]pyrido[2',1': 2,3]imida-z...
- CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model
[作者:Hassan, S; Buchanan, M; Jahan, K; Aguilar-Mahecha, A; Gaboury, L; Muller, WJ; Alsawafi, Y; Mourskaia, AA; Siegel, PM; Salvucci, O; Basik, M,期刊:International Journal of Cancer, 页码:225-232 , 文章类型: Article,,卷期:2011年129-1]
- CXCR4 is a chemokine receptor implicated in the homing of cancer cells to target metastatic organs, which overexpress its ligand, stromal cell-derived factor (SDF)-1. To determine the efficacy of targeting CXCR4 on prima...
- Increased efficacy of doxorubicin delivered in multifunctional microparticles for mesothelioma therapy
[作者:Hillegass, JM; Blumen, SR; Cheng, K; MacPherson, MB; Alexeeva, V; Lathrop, SA; Beuschel, SL; Steinbacher, JL; Butnor, KJ; Ramos-Nino, ME; Shukla, A; James, TA; Weiss, DJ; Taatjes, DJ; Pass, HI; Carbone, M; Landry, CC; Mossman, BT,期刊:International Journal of Cancer, 页码:233-244 , 文章类型: Article,,卷期:2011年129-1]
- New and effective treatment strategies are desperately needed for malignant mesothelioma (MM), an aggressive cancer with a poor prognosis. We have shown previously that acid-prepared mesoporous microspheres (APMS) are no...
- Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
[作者:Wilhelm, SM; Dumas, J; Adnane, L; Lynch, M; Carter, CA; Schutz, G; Thierauch, KH; Zopf, D,期刊:International Journal of Cancer, 页码:245-255 , 文章类型: Article,,卷期:2011年129-1]
- Angiogenesis, a critical driver of tumor development, is controlled by interconnected signaling pathways. Vascular endothelial growth factor receptor (VEGFR) 2 and tyrosine kinase with immunoglobulin and epidermal growth...
- A nation-wide study comparing sporadic and familial adenomatous polyposis-related desmoid-type fibromatoses
[作者:Nieuwenhuis, MH; Casparie, M; Mathus-Vliegen, LMH; Dekkers, OM; Hogendoorn, PCW; Vasen, HFA,期刊:International Journal of Cancer, 页码:256-261 , 文章类型: Article,,卷期:2011年129-1]
- Desmoid-type fibromatoses are neoplasms of fibroblastic origin, occurring sporadically or associated with familial adenomatous polyposis (FAP) coli. By comparing sporadic and FAP-associated desmoid-type fibromatoses, we ...
- Cysteinyl leukotriene receptor expression pattern affects migration of breast cancer cells and survival of breast cancer patients
[作者:Magnusson, C; Liu, J; Ehrnstrom, R; Manjer, J; Jirstrom, K; Andersson, T; Sjolander, A,期刊:International Journal of Cancer, 页码:9-22 , 文章类型: Article,,卷期:2011年129-1]
- The fact that breast cancer patients with local or distal dissemination exhibit decreased survival, promotes a search for novel mechanisms to suppress such tumor progression. Here, we have determined the expression of pr...
- Acetyl-11-keto-beta-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression
[作者:Park, B; Sung, BY; Yadav, VR; Cho, SG; Liu, MY; Aggarwal, BB,期刊:International Journal of Cancer, 页码:23-33 , 文章类型: Article,,卷期:2011年129-1]
- Ninety percent of cancer-mediated deaths are due to metastasis of the tumor; however, the mechanisms controlling metastasis remain poorly understood. Thus, no therapy targeting this process has yet been approved. Chemoki...
- PRKAR1A is overexpressed and represents a possible therapeutic target in human cholangiocarcinoma
[作者:Loilome, W; Juntana, S; Namwat, N; Bhudhisawasdi, V; Puapairoj, A; Sripa, B; Miwa, M; Saya, H; Riggins, GJ; Yongvanit, P,期刊:International Journal of Cancer, 页码:34-44 , 文章类型: Article,,卷期:2011年129-1]
- The protein kinase A regulatory subunit 1 alpha (PRKAR1A/PKAI) pathway is overexpressed in varieties of tumors and cancer cell lines including cholangiocarcinoma (CCA), although its role in CCA growth modulation is uncle...
- Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells
[作者:Ferletta, M; Caglayan, D; Mokvist, L; Jiang, YW; Kastemar, M; Uhrbom, L; Westermark, B,期刊:International Journal of Cancer, 页码:45-60 , 文章类型: Article,,卷期:2011年129-1]
- Numerous studies support a role for Sox2 to keep stem cells and progenitor cells in an immature and proliferative state. Coexpression of Sox2 and GFAP has been found in regions of the adult brain where neural stem cells ...
- BCL6 gene rearrangement and protein expression are associated with large cell presentation of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
[作者:Flossbach, L; Antoneag, E; Buck, M; Siebert, R; Mattfeldt, T; Moller, P; Barth, TFE,期刊:International Journal of Cancer, 页码:70-77 , 文章类型: Article,,卷期:2011年129-1]
- Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is an indolent B-cell lymphoma, which is often localized in the stomach. It is characterized by typical morphology, immunology...
- Integrated genetic and epigenetic analysis of bladder cancer reveals an additive diagnostic value of FGFR3 mutations and hypermethylation events
[作者:Serizawa, RR; Ralfkiaer, U; Steven, K; Lam, GW; Schmiedel, S; Schuz, J; Hansen, AB; Horn, T; Guldberg, P,期刊:International Journal of Cancer, 页码:78-87 , 文章类型: Article,,卷期:2011年129-1]
- The bladder cancer genome harbors numerous oncogenic mutations and aberrantly methylated gene promoters. The aim of our study was to generate a profile of these alterations and investigate their use as biomarkers in urin...
- Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis
[作者:Prakobwong, S; Khoontawad, J; Yongvanit, P; Pairojkul, C; Hiraku, Y; Sithithaworn, P; Pinlaor, P; Aggarwal, BB; Pinlaor, S,期刊:International Journal of Cancer, 页码:88-100 , 文章类型: Article,,卷期:2011年129-1]
- Cholangiocarcinoma (CCA) is a highly metastatic tumor linked to liver fluke infection and consumption of nitrosamine-contaminated foods and is a major health problem especially in South-Eastern Asia. In search for a suit...
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