- Recent Developments in the Chemistry and Biology of G-Quadruplexes with Reference to the DNA Groove Binders
[作者:Jain, AK; Bhattacharya, S,期刊:Current Pharmaceutical Design, 页码:1917-1933 , 文章类型: Review,,卷期:2012年18-14]
- DNA is the chemotherapeutic target for treating diseases of genetic origin. Besides well-known double-helical structures (A, B, Z, parallel stranded-DNA etc.), DNA is capable of forming several multi-stranded structures ...
- Heterocyclic Dications as a New Class of Telomeric G-Quadruplex Targeting Agents
[作者:Nanjunda, R; Musetti, C; Kumar, A; Ismail, MA; Farahat, AA; Wang, SM; Sissi, C; Palumbo, M; Boykin, DW; Wilson, WD,期刊:Current Pharmaceutical Design, 页码:1934-1947 , 文章类型: Review,,卷期:2012年18-14]
- Small molecules that can induce and stabilize G-quadruplex DNA structures represent a novel approach for anti-cancer and anti-parasitic therapy and extensive efforts have been directed towards discovering lead compounds ...
- Screening of a Chemical Library by HT-G4-FID for Discovery of Selective G-quadruplex Binders
[作者:Largy, E; Saettel, N; Hamon, F; Dubruille, S; Teulade-Fichou, MP,期刊:Current Pharmaceutical Design, 页码:1992-2001 , 文章类型: Review,,卷期:2012年18-14]
- Due to the lack of structural guidelines about G-quadruplex ligands, rational design cannot be the only approach to discover potent G4-ligands. As a complementary approach, screening of chemical library may provide inter...
- Thrombin Binding Aptamer, More than a Simple Aptamer: Chemically Modified Derivatives and Biomedical Applications
[作者:Avino, A; Fabrega, C; Tintore, M; Eritja, R,期刊:Current Pharmaceutical Design, 页码:2036-2047 , 文章类型: Review,,卷期:2012年18-14]
- The thrombin binding aptamer (TBA) is a well characterized chair-like, antiparallel quadruplex structure that binds specifically to thrombin at nanomolar concentrations and therefore it has interesting anticoagulant prop...
- G-Quadruplex Based Probes for Visual Detection and Sensing
[作者:Neo, JL; Kamaladasan, K; Uttamchandani, M,期刊:Current Pharmaceutical Design, 页码:2048-2057 , 文章类型: Review,,卷期:2012年18-14]
- Recent advances in colorimetric biosensing have led to rapid methods for target detection, potentially leading to applications on-site, at the point-of-need. This review focuses on one such platform, the G-quadruplex-hem...
- Luminescent G-quadruplex Probes
[作者:Ma, DL; Chan, DSH; Yang, H; He, HZ; Leung, CH,期刊:Current Pharmaceutical Design, 页码:2058-2075 , 文章类型: Review,,卷期:2012年18-14]
- G-quadruplexes have found increasing potential in applications such as molecular therapeutics, diagnostics, and sensing. As a consequence, small molecules capable of selectively detecting G-quadruplexes have received sig...
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