- Physical and Functional Interactions of Caenorhabditis elegans WRN-1 Helicase with RPA-1
[作者:Hyun, M; Park, S; Kim, E; Kim, DH; Lee, SJ; Koo, HS; Seo, YS; Ahn, B,期刊:Biochemistry, 页码:1336-1345 , 文章类型: Article,,卷期:2012年51-7]
- The Caenorhabditis elegans Werner syndrome protein, WRN-1, a member of the RecQ helicase family, has a 3'-5' DNA helicase activity. Worms with defective wrn-1 exhibit premature aging phenotypes and an increased level of ...
- Second Monomer Binding Is the Rate-Limiting Step in the Formation of the Dimeric PhoP-DNA Complex
[作者:Singh, V; Ekka, MK; Kumaran, S,期刊:Biochemistry, 页码:1346-1356 , 文章类型: Article,,卷期:2012年51-7]
- PhoP, the response regulator of the PhoP/PhoQ system, regulates Mg2+ homeostasis in Salmonella typhimurium. Dimerization of PhoP on the DNA is necessary for its regulatory function, and PhoP regulates the expression of g...
- Role of the Helical Structure of the N-Terminal Region of Plasmodium falciparum Merozoite Surface Protein 2 in Fibril Formation and Membrane Interaction
[作者:Zhang, XC; Adda, CG; Low, A; Zhang, JH; Zhang, W; Sun, HB; Tu, XM; Anders, RF; Norton, RS,期刊:Biochemistry, 页码:1380-1387 , 文章类型: Article,,卷期:2012年51-7]
- Merozoite surface protein 2 (MSP2), an abundant glycosylphosphatidylinositol-anchored protein on the surface of Plasmodium falciparum merozoites, is a promising malaria vaccine candidate. MSP2 is intrinsically disordered...
- Positional Effects of Phosphorylation on the Stability and Morphology of Tau-Related Amyloid Fibrils
[作者:Inoue, M; Konno, T; Tainaka, K; Nakata, E; Yoshida, H; Morii, T,期刊:Biochemistry, 页码:1396-1406 , 文章类型: Article,,卷期:2012年51-7]
- Hyperphosphorylated forms of tau protein are the main component of paired helical filaments (PHFs) of neurofibrillary tangles in the brain of Alzheimer's disease patients. To understand the effect of phosphorylation on t...
- Nonionic Homopolymeric Amphipols: Application to Membrane Protein Folding, Cell-Free Synthesis, and Solution Nuclear Magnetic Resonance
[作者:Bazzacco, P; Billon-Denis, E; Sharma, KS; Catoire, LJ; Mary, S; Le Bon, C; Point, E; Baneres, JL; Durand, G; Zito, F; Pucci, B; Popot, JL,期刊:Biochemistry, 页码:1416-1430 , 文章类型: Article,,卷期:2012年51-7]
- Nonionic amphipols (NAPols) synthesized by homotelomerization of an amphiphatic monomer are able to keep membrane proteins (MPs) stable and functional in the absence of detergent. Some of their biochemical and biophysica...
- Cu(I) Affinities of the Domain 1 and 3 Sites in the Human Metallochaperone for Cu,Zn-Superoxide Dismutase
[作者:Allen, S; Badarau, A; Dennison, C,期刊:Biochemistry, 页码:1439-1448 , 文章类型: Article,,卷期:2012年51-7]
- The delivery of copper by the human metallochaperone CCS is a key step in the activation of Cu,Zn-superoxide dismutase (SOD1). CCS is a three-domain protein with Cu(I)-binding CXXC and CXC motifs in domains 1 and 3, resp...
- Cancer Somatic Mutations Disrupt Functions of the EphA3 Receptor Tyrosine Kinase through Multiple Mechanisms
[作者:Lisabeth, EM; Fernandez, C; Pasquale, EB,期刊:Biochemistry, 页码:1464-1475 , 文章类型: Article,,卷期:2012年51-7]
- The Eph receptor tyrosine kinases make up an important family of signal transduction molecules that control many cellular processes, including cell adhesion and movement, cell shape, and cell growth. All of these are imp...
- Structural Basis for Differential Insertion Kinetics of dNMPs Opposite a Difluorotoluene Nucleotide Residue
[作者:Xia, SL; Eom, SH; Konigsberg, WH; Wang, JM,期刊:Biochemistry, 页码:1476-1485 , 文章类型: Article,,卷期:2012年51-7]
- We have recently challenged the widely held view that 2,4-difluorotoluene (dF) is a nonpolar isosteric analogue of the nucleotide dT, incapable of forming hydrogen bonds (HBs). To gain a further understanding for the kin...
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