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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   The Medicinal Chemistry of Ubiquitin-Proteasome Pathway (UPP) and Its Relevance in Drug Discovery [作者：Zhu, YQ,期刊：Current Topics in Medicinal Chemistry, 页码：2849-2849 , 文章类型： Editorial Material，,卷期：2011年11-23] Proteasome Structure, Function, and Lessons Learned from Beta-Lactone Inhibitors [作者：Groll, M; Potts, BC,期刊：Current Topics in Medicinal Chemistry, 页码：2850-2878 , 文章类型： Review，,卷期：2011年11-23] The 26S proteasome is the enzymatic core engine of the ubiquitin and proteasome dependent proteolytic system (UPS), the major eukaryotic pathway for regulated protein degradation. The UPS plays a pivotal role in cellular... Ubiquitination in Rho Signaling [作者：Ding, F; Yin, ZY; Wang, HR,期刊：Current Topics in Medicinal Chemistry, 页码：2879-2887 , 文章类型： Review，,卷期：2011年11-23] The Rho family small GTPases of the Ras superfamily play key roles in regulating diverse signaling pathways that control a myriad of fundamental cellular processes such as cytoskeletal dynamics, cell cycle progression, g... Targeting the Ubiquitin-Proteasome Pathway: An Emerging Concept in Cancer Therapy [作者：Frezza, M; Schmitt, S; Dou, QP,期刊：Current Topics in Medicinal Chemistry, 页码：2888-2905 , 文章类型： Review，,卷期：2011年11-23] Selective degradation of proteins by the ubiquitin-proteasome pathway is a critical determinant for maintaining cellular homeostasis. Most intracellular proteins are degraded by the proteasome, a multicatalytic enzyme co... Synthesis of Salinosporamide A and Its Analogs as 20S Proteasome Inhibitors and SAR Summarization [作者：Ma, YH; Qu, LL; Liu, ZM; Zhang, LG; Yang, ZJ; Zhang, LH,期刊：Current Topics in Medicinal Chemistry, 页码：2906-2922 , 文章类型： Review，,卷期：2011年11-23] Salinosporamide A (4), a secondary metabolite of the marine actinomycete Salinispora tropica, is a potent inhibitor of 20S proteasome that is currently in clinical trials for the treatment of cancers. Herein, we describe... The Immunoproteasome: An Emerging Therapeutic Target [作者：Lee, W; Kim, KB,期刊：Current Topics in Medicinal Chemistry, 页码：2923-2930 , 文章类型： Review，,卷期：2011年11-23] The proteasome, a large multisubunit protease complex, has been extensively investigated over the years, greatly enhancing our understanding of critical roles that the proteasome plays in cells. The FDA approval of borte... Progress of Computer-Aided Drug Design (CADD) of Proteasome Inhibitors [作者：Lei, M; Liu, YD; Zhu, YQ; Liu, ZM,期刊：Current Topics in Medicinal Chemistry, 页码：2931-2944 , 文章类型： Review，,卷期：2011年11-23] The target proteasome has been the focus of drug discovery since the first drug bortezomib was launched in 2003. Many structurally diverse proteasome inhibitors were discovered and even some of them entered the clinical ...