- Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking
[作者:Barthel, SR; Wiese, GK; Cho, JH; Opperman, MJ; Hays, DL; Siddiqui, J; Pienta, KJ; Furie, B; Dimitroff, CJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19491-19496 , 文章类型: Article,,卷期:2009年106-46]
- How cancer cells bind to vascular surfaces and extravasate into target organs is an underappreciated, yet essential step in metastasis. We postulate that the metastatic process involves discrete adhesive interactions bet...
- Alternatively spliced tissue factor induces angiogenesis through integrin ligation
[作者:van den Berg, YW; van den Hengel, LG; Myers, HR; Ayachi, O; Jordanova, E; Ruf, W; Spek, CA; Reitsma, PH; Bogdanov, VY; Versteeg, HH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19497-19502 , 文章类型: Article,,卷期:2009年106-46]
- The initiator of coagulation, full-length tissue factor (flTF), in complex with factor VIIa, influences angiogenesis through PAR-2. Recently, an alternatively spliced variant of TF (asTF) was discovered, in which part of...
- Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes
[作者:Thomson, R; Molina-Portela, P; Mott, H; Carrington, M; Raper, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19509-19514 , 文章类型: Article,,卷期:2009年106-46]
- Several species of African trypanosomes cause fatal disease in livestock, but most cannot infect humans due to innate trypanosome lytic factors (TLFs). Human TLFs are pore forming high-density lipoprotein (HDL) particles...
- Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays
[作者:Adato, R; Yanik, AA; Amsden, JJ; Kaplan, DL; Omenetto, FG; Hong, MK; Erramilli, S; Altug, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19227-19232 , 文章类型: Article,,卷期:2009年106-46]
- Infrared absorption spectroscopy enabling direct access to vibrational fingerprints of the molecular structure is a powerful method for functional studies of bio-molecules. Although the intrinsic absorption cross-section...
- High-pressure highly reduced nitrides and oxides from chromitite of a Tibetan ophiolite
[作者:Dobrzhinetskaya, LF; Wirth, R; Yang, JS; Hutcheon, ID; Weber, PK; Green, HW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19233-19238 , 文章类型: Article,,卷期:2009年106-46]
- The deepest rocks known from within Earth are fragments of normal mantle (approximate to 400 km) and metamorphosed sediments (approximate to 350 km), both found exhumed in continental collision terranes. Here, we report ...
- Cellular stress created by intermediary metabolite imbalances
[作者:Lee, SJ; Trostel, A; Le, P; Harinarayanan, R; FitzGerald, PC; Adhya, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19515-19520 , 文章类型: Article,,卷期:2009年106-46]
- Small molecules generally activate or inhibit gene transcription as externally added substrates or as internally accumulated end-products, respectively. Rarely has a connection been made that links an intracellular inter...
- Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11
[作者:Mo, M; Fleming, SB; Mercer, AA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19527-19532 , 文章类型: Article,,卷期:2009年106-46]
- The anaphase-promoting complex (APC), or cyclosome, is a ubiquitin ligase with major roles in cell cycle regulation. It is required for mitotic exit, but must be deactivated for the G(1)/S phase transition to occur. APC ...
- Direct observation of twisting steps during Rad51 polymerization on DNA
[作者:Arata, H; Dupont, A; Mine-Hattab, J; Disseau, L; Renodon-Corniere, A; Takahashi, M; Viovy, JL; Cappello, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19239-19244 , 文章类型: Article,,卷期:2009年106-46]
- The human recombinase hRad51 is a key protein for the maintenance of genome integrity and for cancer development. Polymerization and depolymerization of hRad51 on duplex DNA were studied here using a new generation of ma...
- A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota
[作者:Cong, YZ; Feng, T; Fujihashi, K; Schoeb, TR; Elson, CO,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19256-19261 , 文章类型: Article,,卷期:2009年106-46]
- A T cell receptor transgenic mouse line reactive to a microbiota flagellin, CBir1, was used to define mechanisms of host microbiota homeostasis. Intestinal IgA, but not serum IgA, was found to block mucosal flagellin upt...
- Contagious yawning in gelada baboons as a possible expression of empathy
[作者:Palagi, E; Leone, A; Mancini, G; Ferrari, PF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19262-19267 , 文章类型: Article,,卷期:2009年106-46]
- Yawn contagion in humans has been proposed to be related to our capacity for empathy. It is presently unclear whether this capacity is uniquely human or shared with other primates, especially monkeys. Here, we show that ...
- A key role for vesicles in fungal secondary metabolism
[作者:Chanda, A; Roze, LV; Kang, S; Artymovich, KA; Hicks, GR; Raikhel, NV; Calvo, AM; Linz, JE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19533-19538 , 文章类型: Article,,卷期:2009年106-46]
- Eukaryotes have evolved highly conserved vesicle transport machinery to deliver proteins to the vacuole. In this study we show that the filamentous fungus Aspergillus parasiticus employs this delivery system to perform n...
- HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain
[作者:Iwatani, Y; Chan, DSB; Liu, L; Yoshii, H; Shibata, J; Yamamoto, N; Levin, JG; Gronenborn, AM; Sugiura, W,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19539-19544 , 文章类型: Article,,卷期:2009年106-46]
- During coevolution with the host, HIV-1 developed the ability to hijack the cellular ubiquitin/proteasome degradation pathway to counteract the antiviral activity of APOBEC3G (A3G), a host cytidine deaminase that can blo...
- Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier
[作者:Tang, BC; Dawson, M; Lai, SK; Wang, YY; Suk, JS; Yang, M; Zeitlin, P; Boyle, MP; Fu, J; Hanes, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19268-19273 , 文章类型: Article,,卷期:2009年106-46]
- Protective mucus coatings typically trap and rapidly remove foreign particles from the eyes, gastrointestinal tract, airways, nasopharynx, and female reproductive tract, thereby strongly limiting opportunities for contro...
- Evolution amplified processing with temporally dispersed slow neuronal connectivity in primates
[作者:Caminiti, R; Ghaziri, H; Galuske, R; Hof, PR; Innocenti, GM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19551-19556 , 文章类型: Article,,卷期:2009年106-46]
- The corpus callosum (CC) provides the main route of communication between the 2 hemispheres of the brain. In monkeys, chimpanzees, and humans, callosal axons of distinct size interconnect functionally different cortical ...
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