- Illuminating cell-cycle progression in the developing zebrafish embryo
[作者:Sugiyama, M; Sakaue-Sawano, A; Iimura, T; Fukami, K; Kitaguchi, T; Kawakami, K; Okamoto, H; Higashijima, SI; Miyawaki, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20812-20817 , 文章类型: Article,,卷期:2009年106-49]
- By exploiting the cell-cycle-dependent proteolysis of two ubiquitination oscillators, human Cdt1 and geminin, which are the direct substrates of SCFSkp2 and APC(Cdh1) complexes, respectively, Fucci technique labels mamma...
- Use of high throughput sequencing to observe genome dynamics at a single cell level
[作者:Parkhomchuk, D; Amstislavskiy, V; Soldatov, A; Ogryzko, V,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20830-20835 , 文章类型: Article,,卷期:2009年106-49]
- With the development of high throughput sequencing technology, it becomes possible to directly analyze mutation distribution in a genome-wide fashion, dissociating mutation rate measurements from the traditional underlyi...
- Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity
[作者:Balsamo, M; Scordamaglia, F; Pietra, G; Manzini, C; Cantoni, C; Boitano, M; Queirolo, P; Vermi, W; Facchetti, F; Moretta, A; Moretta, L; Mingari, MC; Vitale, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20847-20852 , 文章类型: Article,,卷期:2009年106-49]
- Although the role of the tumor microenvironment in the process of cancer progression has been extensively investigated, the contribution of different stromal components to tumor growth and/or evasion from immune surveill...
- The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling
[作者:DiAngelo, JR; Bland, ML; Bambina, S; Cherry, S; Birnbaum, MJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20853-20858 , 文章类型: Article,,卷期:2009年106-49]
- Innate immunity is the primary and most ancient defense against infection. Although critical to survival, coordinating protection against a foreign organism is energetically costly, creating the need to reallocate substr...
- Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir
[作者:Beck-Engeser, GB; Eilat, D; Harrer, T; Jack, HM; Wabl, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20865-20870 , 文章类型: Article,,卷期:2009年106-49]
- Raltegravir is a recently, Food and Drug Administration-approved, small-molecule drug that inhibits retroviral integrase, thereby preventing HIV DNA from inserting itself into the human genome. We report here that the ac...
- Clonal expansions in ulcerative colitis identify patients with neoplasia
[作者:Salk, JJ; Salipante, SJ; Risques, RA; Crispin, DA; Li, L; Bronner, MP; Brentnall, TA; Rabinovitch, PS; Horwitz, MS; Loeb, LA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20871-20876 , 文章类型: Article,,卷期:2009年106-49]
- Chronic inflammation predisposes to a variety of human cancers. Affected tissues slowly accumulate mutations, some of which affect growth regulation and drive successive waves of clonal evolution, whereas a far greater n...
- The integrin alpha(4)beta(7) forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
[作者:Cicala, C; Martinelli, E; McNally, JP; Goode, DJ; Gopaul, R; Hiatt, J; Jelicic, K; Kottilil, S; Macleod, K; O'Shea, A; Patel, N; Van Ryk, D; Wei, DL; Pascuccio, M; Yi, L; McKinnon, L; Izulla, P; Kimani, J; Kaul, R; Fauci, AS; Arthos, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20877-20882 , 文章类型: Article,,卷期:2009年106-49]
- Both activated and resting CD4(+) T cells in mucosal tissues play important roles in the earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient. HIV-1 gp120 binds to integrin alpha...
- Dust as a tipping element: The Bodele Depression, Chad
[作者:Washington, R; Bouet, C; Cautenet, G; Mackenzie, E; Ashpole, I; Engelstaedter, S; Lizcano, G; Henderson, GM; Schepanski, K; Tegen, I,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20564-20571 , 文章类型: Article,,卷期:2009年106-49]
- Dust plays a vital role in climate and biophysical feedbacks in the Earth system. One source of dust, the Bodele Depression in Chad, is estimated to produce about half the mineral aerosols emitted from the Sahara, which ...
- Synergy between bacterial infection and genetic predisposition in intestinal dysplasia
[作者:Apidianakis, Y; Pitsouli, C; Perrimon, N; Rahme, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20883-20888 , 文章类型: Article,,卷期:2009年106-49]
- Accumulating evidence suggests that hyperproliferating intestinal stem cells (SCs) and progenitors drive cancer initiation, maintenance, and metastasis. In addition, chronic inflammation and infection have been increasin...
- Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration
[作者:Gupta, RK; Mlcochova, P; Pelchen-Matthews, A; Petit, SJ; Mattiuzzo, G; Pillay, D; Takeuchi, Y; Marsh, M; Towers, GJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20889-20894 , 文章类型: Article,,卷期:2009年106-49]
- Tetherin is an IFN-inducible restriction factor that inhibits HIV-1 particle release in the absence of the HIV-1 countermeasure, viral protein U (Vpu). Although ubiquitous in HIV-1 and simian immunodeficiency viruses fro...
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