- The dark sides of capillary morphogenesis gene 2
[作者:Deuquet, J; Lausch, E; Superti-Furga, A; van der Goot, FG,期刊:EMBO journal, 页码:3-13 , 文章类型: Review,,卷期:2012年31-1]
- Capillary morphogenesis gene 2 (CMG2) is a type I membrane protein involved in the homeostasis of the extracellular matrix. While it shares interesting similarities with integrins, its exact molecular role is unknown. Th...
- IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation
[作者:Oberoi, TK; Dogan, T; Hocking, JC; Scholz, RP; Mooz, J; Anderson, CL; Karreman, C; Heringdorf, DMZ; Schmidt, G; Ruonala, M; Namikawa, K; Harms, GS; Carpy, A; Macek, B; Koster, RW; Rajalingam, K,期刊:EMBO journal, 页码:14-28 , 文章类型: Article,,卷期:2012年31-1]
- Inhibitors of apoptosis proteins (IAPs) are a highly conserved class of multifunctional proteins. Rac1 is a well- studied Rho GTPase that controls numerous basic cellular processes. While the regulation of nucleotide bin...
- Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation
[作者:Zhang, K; Rodriguez-Aznar, E; Yabuta, N; Owen, RJ; Mingot, JM; Nojima, H; Nieto, MA; Longmore, GD,期刊:EMBO journal, 页码:29-43 , 文章类型: Article,,卷期:2012年31-1]
- Snail1 is a central regulator of epithelial cell adhesion and movement in epithelial-to-mesenchymal transitions (EMTs) during embryo development; a process reactivated during cancer metastasis. While induction of Snail1 ...
- Distinct role of Mediator tail module in regulation of SAGA-dependent, TATA-containing genes in yeast
[作者:Ansari, SA; Ganapathi, M; Benschop, JJ; Holstege, FCP; Wade, JT; Morse, RH,期刊:EMBO journal, 页码:44-57 , 文章类型: Article,,卷期:2012年31-1]
- The evolutionarily conserved Mediator complex is required for transcription of nearly all RNA Pol II-dependent promoters, with the tail module serving to recruit Mediator to active promoters in current models. However, t...
- MYST protein acetyltransferase activity requires active site lysine autoacetylation
[作者:Yuan, H; Rossetto, D; Mellert, H; Dang, WW; Srinivasan, M; Johnson, J; Hodawadekar, S; Ding, EC; Speicher, K; Abshiru, N; Perry, R; Wu, J; Yang, C; Zheng, YG; Speicher, DW; Thibault, P; Verreault, A; Johnson, FB; Berger, SL; Sternglanz, R; McMahon, SB; Cote, J; Marmorstein, R,期刊:EMBO journal, 页码:58-70 , 文章类型: Article,,卷期:2012年31-1]
- The MYST protein lysine acetyltransferases are evolutionarily conserved throughout eukaryotes and acetylate proteins to regulate diverse biological processes including gene regulation, DNA repair, cell-cycle regulation, ...
- Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin
[作者:Whelan, G; Kreidl, E; Wutz, G; Egner, A; Peters, JM; Eichele, G,期刊:EMBO journal, 页码:71-82 , 文章类型: Article,,卷期:2012年31-1]
- Sister chromatid cohesion, mediated by cohesin and regulated by Sororin, is essential for chromosome segregation. In mammalian cells, cohesion establishment and Sororin recruitment to chromatin-bound cohesin depends on t...
- Nuclear retention of importin alpha coordinates cell fate through changes in gene expression
[作者:Yasuda, Y; Miyamoto, Y; Yamashiro, T; Asally, M; Masui, A; Wong, C; Loveland, KL; Yoneda, Y,期刊:EMBO journal, 页码:83-94 , 文章类型: Article,,卷期:2012年31-1]
- Various cellular stresses including oxidative stress induce a collapse of the Ran gradient, which causes accumulation of importin alpha in the nucleus and a subsequent block of nuclear protein import. However, it is unkn...
- Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence
[作者:Martin, N; Benhamed, M; Nacerddine, K; Demarque, MD; van Lohuizen, M; Dejean, A; Bischof, O,期刊:EMBO journal, 页码:95-109 , 文章类型: Article,,卷期:2012年31-1]
- Cellular senescence acts as a potent barrier for tumour initiation and progression. Previous studies showed that the PML tumour suppressor promotes senescence, although the precise mechanisms remain to be elucidated. Com...
- SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities
[作者:Yang, F; Sun, LY; Li, Q; Han, X; Lei, LD; Zhang, H; Shang, YF,期刊:EMBO journal, 页码:110-123 , 文章类型: Article,,卷期:2012年31-1]
- SET8 is implicated in transcriptional regulation, heterochromatin formation, genomic stability, cell-cycle progression, and development. As such, it is predicted that SET8 might be involved in the development and progres...
- Nucleosomal organization of replication origins and meiotic recombination hotspots in fission yeast
[作者:de Castro, E; Soriano, I; Marin, L; Serrano, R; Quintales, L; Antequera, F,期刊:EMBO journal, 页码:124-137 , 文章类型: Article,,卷期:2012年31-1]
- In Schizosaccharomyces pombe, DNA replication origins (ORIs) and meiotic recombination hotspots lack consensus sequences and show a bias towards mapping to large intergenic regions (IGRs). To explore whether this prefere...
- DNA-end capping by the budding yeast transcription factor and subtelomeric binding protein Tbf1
[作者:Ribaud, V; Ribeyre, C; Damay, P; Shore, D,期刊:EMBO journal, 页码:138-149 , 文章类型: Article,,卷期:2012年31-1]
- Telomere repeats in budding yeast are maintained at a constant average length and protected ('capped'), in part, by mechanisms involving the TG(1-3) repeat-binding protein Rap1. However, metazoan telomere repeats (T(2)AG...
- RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency
[作者:Qi, XD; Xie, MY; Brown, AF; Bley, CJ; Podlevsky, JD; Chen, JJL,期刊:EMBO journal, 页码:150-161 , 文章类型: Article,,卷期:2012年31-1]
- Telomerase synthesizes telomeric DNA repeats onto chromosome termini from an intrinsic RNA template. The processive synthesis of DNA repeats relies on a unique, yet poorly understood, mechanism whereby the telomerase RNA...
- Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease
[作者:Schmidt, V; Baum, K; Lao, A; Rateitschak, K; Schmitz, Y; Teichmann, A; Wiesner, B; Petersen, CM; Nykjaer, A; Wolf, J; Wolkenhauer, O; Willnow, TE,期刊:EMBO journal, 页码:187-200 , 文章类型: Article,,卷期:2012年31-1]
- The extent of proteolytic processing of the amyloid precursor protein (APP) into neurotoxic amyloid-beta (A beta) peptides is central to the pathology of Alzheimer's disease (AD). Accordingly, modifiers that increase A b...
- Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis
[作者:Schwandt, T; Schumak, B; Gielen, GH; Jungerkes, F; Schmidbauer, P; Klocke, K; Staratschek-Jox, A; van Rooijen, N; Kraal, G; Ludwig-Portugall, I; Franken, L; Wehner, S; Kalff, JC; Weber, O; Kirschning, C; Coch, C; Kalinke, U; Wenzel, J; Kurts, C; Zawatzky, R; Holzmann, B; Layland, L; Schultze, JL; Burgdorf, S; den Haan, JMM; Knolle, PA; Limmer, A,期刊:EMBO journal, 页码:201-213 , 文章类型: Article,,卷期:2012年31-1]
- Early during Gram-negative sepsis, excessive release of pro-inflammatory cytokines can cause septic shock that is often followed by a state of immune paralysis characterized by the failure to mount adaptive immunity towa...
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