- Axolotl Nanog activity in mouse embryonic stem cells demonstrates that ground state pluripotency is conserved from urodele amphibians to mammals
[作者:Dixon, JE; Allegrucci, C; Redwood, C; Kump, K; Bian, YH; Chatfield, J; Chen, YH; Sottile, V; Voss, SR; Alberio, R; Johnson, AD,期刊:Development, 页码:2973-2980 , 文章类型: Article,,卷期:2010年137-18]
- Cells in the pluripotent ground state can give rise to somatic cells and germ cells, and the acquisition of pluripotency is dependent on the expression of Nanog. Pluripotency is conserved in the primitive ectoderm of emb...
- BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors
[作者:Tirosh-Finkel, L; Zeisel, A; Brodt-Ivenshitz, M; Shamai, A; Yao, Z; Seger, R; Domany, E; Tzahor, E,期刊:Development, 页码:2989-3000 , 文章类型: Article,,卷期:2010年137-18]
- The anterior heart field (AHF) encompasses a niche in which mesoderm-derived cardiac progenitors maintain their multipotent and undifferentiated nature in response to signals from surrounding tissues. Here, we investigat...
- Arterial pole progenitors interpret opposing FGF/BMP signals to proliferate or differentiate
[作者:Hutson, MR; Zeng, XL; Kim, AJ; Antoon, E; Harward, S; Kirby, ML,期刊:Development, 页码:3001-3011 , 文章类型: Article,,卷期:2010年137-18]
- During heart development, a subpopulation of cells in the heart field maintains cardiac potential over several days of development and forms the myocardium and smooth muscle of the arterial pole. Using clonal and explant...
- BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation
[作者:Mitsiadis, TA; Graf, D; Luder, H; Gridley, T; Bluteau, G,期刊:Development, 页码:3025-3035 , 文章类型: Article,,卷期:2010年137-18]
- The Notch signalling pathway is an evolutionarily conserved intercellular signalling mechanism that is essential for cell fate specification and proper embryonic development. We have analysed the expression, regulation a...
- Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II
[作者:Hirota, Y; Meunier, A; Huang, S; Shimozawa, T; Yamada, O; Kida, YS; Inoue, M; Ito, T; Kato, H; Sakaguchi, M; Sunabori, T; Nakaya, MA; Nonaka, S; Ogura, T; Higuchi, H; Okano, H; Spassky, N; Sawamoto, K,期刊:Development, 页码:3037-3046 , 文章类型: Article,,卷期:2010年137-18]
- Motile cilia generate constant fluid flow over epithelial tissue, and thereby influence diverse physiological processes. Such functions of ciliated cells depend on the planar polarity of the cilia and on their basal bodi...
- In vivo evidence for transdifferentiation of peripheral neurons
[作者:Wright, MA; Mo, W; Nicolson, T; Ribera, AB,期刊:Development, 页码:3047-3056 , 文章类型: Article,,卷期:2010年137-18]
- It is commonly thought that differentiated neurons do not give rise to new cells, severely limiting the potential for regeneration and repair of the mature nervous system. However, we have identified cells in zebrafish l...
- The role of Drosophila Lamin C in muscle function and gene expression
[作者:Dialynas, G; Speese, S; Budnik, V; Geyer, PK; Wallrath, LL,期刊:Development, 页码:3067-3077 , 文章类型: Article,,卷期:2010年137-18]
- The inner side of the nuclear envelope (NE) is lined with lamins, a meshwork of intermediate filaments that provides structural support for the nucleus and plays roles in many nuclear processes. Lamins, classified as A- ...
- The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure
[作者:Mao, JZ; McKean, DM; Warrier, S; Corbin, JG; Niswander, L; Zohn, IE,期刊:Development, 页码:3079-3088 , 文章类型: Article,,卷期:2010年137-18]
- Neural tube defects (NTDs) are some of the most common birth defects observed in humans. The incidence of NTDs can be reduced by peri-conceptional folic acid supplementation alone and reduced even further by supplementat...
- An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain
[作者:Poitras, L; Yu, M; Lesage-Pelletier, C; MacDonald, RB; Gagne, JP; Hatch, G; Kelly, I; Hamilton, SP; Rubenstein, JLR; Poirier, GG; Ekker, M,期刊:Development, 页码:3089-3097 , 文章类型: Article,,卷期:2010年137-18]
- Dlx homeobox genes play a crucial role in the migration and differentiation of the subpallial precursor cells that give rise to various subtypes of gamma-aminobutyric acid (GABA)-expressing neurons of the forebrain, incl...
- Sall1-dependent signals affect Wnt signaling and ureter tip fate to initiate kidney development
[作者:Kiefer, SM; Robbins, L; Stumpff, KM; Lin, C; Ma, L; Rauchman, M,期刊:Development, 页码:3099-3106 , 文章类型: Article,,卷期:2010年137-18]
- Development of the metanephric kidney depends on precise control of branching of the ureteric bud. Branching events represent terminal bifurcations that are thought to depend on unique patterns of gene expression in the ...
- HLH54F is required for the specification and migration of longitudinal gut muscle founders from the caudal mesoderm of Drosophila
[作者:Ismat, A; Schaub, C; Reim, I; Kirchner, K; Schultheis, D; Frasch, M,期刊:Development, 页码:3107-3117 , 文章类型: Article,,卷期:2010年137-18]
- HLH54F, the Drosophila ortholog of the vertebrate basic helix-loop-helix domain-encoding genes capsulin and musculin, is expressed in the founder cells and developing muscle fibers of the longitudinal midgut muscles. The...
- Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis
[作者:Wang, Y; Kaiser, MS; Larson, JD; Nasevicius, A; Clark, KJ; Wadman, SA; Roberg-Perez, SE; Ekker, SC; Hackett, PB; McGrail, M; Essner, JJ,期刊:Development, 页码:3119-3128 , 文章类型: Article,,卷期:2010年137-18]
- Endothelial tubulogenesis is a crucial step in the formation of functional blood vessels during angiogenesis and vasculogenesis. Here, we use in vivo imaging of living zebrafish embryos expressing fluorescent fusion prot...
|