- The Groucho ortholog UNC-37 interacts with the short Groucho-like protein LSY-22 to control developmental decisions in C. elegans
[作者:Flowers, EB; Poole, RJ; Tursun, B; Bashllari, E; Pe'er, I; Hobert, O,期刊:Development, 页码:1799-1805 , 文章类型: Article,,卷期:2010年137-11]
- Transcriptional co-repressors of the Groucho/TLE family are important regulators of development in many species. A subset of Groucho/TLE family members that lack the C-terminal WD40 domains have been proposed to act as d...
- Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila
[作者:Renault, AD; Kunwar, PS; Lehmann, R,期刊:Development, 页码:1815-1823 , 文章类型: Article,,卷期:2010年137-11]
- In Drosophila, germ cell survival and directionality of migration are controlled by two lipid phosphate phosphatases (LPP), wunen (wun) and wunen-2 (wun2). wun wun2 double mutant analysis reveals that the two genes, here...
- The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor
[作者:Vaccari, T; Duchi, S; Cortese, K; Tacchetti, C; Bilder, D,期刊:Development, 页码:1825-1832 , 文章类型: Article,,卷期:2010年137-11]
- Evidence indicates that endosomal entry promotes signaling by the Notch receptor, but the mechanisms involved are not clear. In a search for factors that regulate Notch activation in endosomes, we isolated mutants in Dro...
- Notch signaling, wt1 and foxc2 are key regulators of the podocyte gene regulatory network in Xenopus
[作者:White, JT; Zhang, B; Cerqueira, DM; Tran, U; Wessely, O,期刊:Development, 页码:1863-1873 , 文章类型: Article,,卷期:2010年137-11]
- Podocytes are highly specialized cells in the vertebrate kidney. They participate in the formation of the size-exclusion barrier of the glomerulus/glomus and recruit mesangial and endothelial cells to form a mature glome...
- Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain
[作者:Shimizu, T; Nakazawa, M; Kani, S; Bae, YK; Shimizu, T; Kageyama, R; Hibi, M,期刊:Development, 页码:1875-1885 , 文章类型: Article,,卷期:2010年137-11]
- Precise control of neuronal differentiation is necessary for generation of a variety of neurons in the forebrain. However, little is known about transcriptional cascades, which initiate forebrain neurogenesis. Here we sh...
- The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis
[作者:Deacon, DC; Nevis, KR; Cashman, TJ; Zhou, Y; Zhao, L; Washko, D; Guner-Ataman, B; Burns, CG; Burns, CE,期刊:Development, 页码:1887-1896 , 文章类型: Article,,卷期:2010年137-11]
- Discovering the genetic and cellular mechanisms that drive cardiac morphogenesis remains a fundamental goal, as three-dimensional architecture greatly impacts functional capacity. During development, accurately contoured...
- The basic helix-loop-helix transcription factor Nato3 controls neurogenic activity in mesencephalic floor plate cells
[作者:Ono, Y; Nakatani, T; Minaki, Y; Kumai, M,期刊:Development, 页码:1897-1906 , 文章类型: Article,,卷期:2010年137-11]
- Floor plate (FP) cells, the ventral midline cells of the developing neural tube, have long been thought to be non-neurogenic organizer cells that control neuronal patterning and axonal guidance. Recent studies have revea...
- Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors
[作者:Lizarraga, SB; Margossian, SP; Harris, MH; Campagna, DR; Han, AP; Blevins, S; Mudbhary, R; Barker, JE; Walsh, CA; Fleming, MD,期刊:Development, 页码:1907-1917 , 文章类型: Article,,卷期:2010年137-11]
- Microcephaly affects similar to 1% of the population and is associated with mental retardation, motor defects and, in some cases, seizures. We analyzed the mechanisms underlying brain size determination in a mouse model ...
- The BMP pathway acts to directly regulate Tbx20 in the developing heart
[作者:Mandel, EM; Kaltenbrun, E; Callis, TE; Zeng, XXI; Marques, SR; Yelon, D; Wang, DZ; Conlon, FL,期刊:Development, 页码:1919-1929 , 文章类型: Article,,卷期:2010年137-11]
- TBX20 has been shown to be essential for vertebrate heart development. Mutations within the TBX20 coding region are associated with human congenital heart disease, and the loss of Tbx20 in a wide variety of model systems...
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