- Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cells
[作者:Dash, R; Dmitriev, I; Su, ZZ; Bhutia, SK; Azab, B; Vozhilla, N; Yacoub, A; Dent, P; Curiel, DT; Sarkar, D; Fisher, PB,期刊:Cancer gene therapy, 页码:447-456 , 文章类型: Article,,卷期:2010年17-7]
- Gene therapy is being examined as a potential strategy for treating prostate cancer. Serotype 5 adenovirus (Ad.5) is routinely used as a vector for transgene delivery. However, the infectivity of Ad.5 is dependent on Cox...
- Bleomycin/interleukin-12 electrochemogene therapy for treating naturally occurring spontaneous neoplasms in dogs
[作者:Reed, SD; Fulmer, A; Buckholz, J; Zhang, B; Cutrera, J; Shiomitsu, K; Li, S,期刊:Cancer gene therapy, 页码:457-464 , 文章类型: Article,,卷期:2010年17-7]
- On the basis of superior outcomes from electrochemogene therapy (ECGT) compared with electrochemotherapy in mice, we determined the efficacy of ECGT applied to spontaneous canine neoplasms. Intralesional bleomycin and fe...
- Gene-modified tumor vaccine secreting a designer cytokine Hyper-Interleukin-6 is an effective therapy in mice bearing orthotopic renal cell cancer
[作者:Wysocki, PJ; Kazimierczak, U; Suchorska, W; Kotlarski, M; Malicki, J; Mackiewicz, A,期刊:Cancer gene therapy, 页码:465-475 , 文章类型: Article,,卷期:2010年17-7]
- Although Renal Cell Cancer (RCC) is known to be immunogenic, clinical efficacy of various immunotherapeutic approaches remains unsatisfactory. Novel targeted therapies showing cytostatic rather than cytotoxic activity ar...
- Treatment of metastatic neuroblastoma with systemic oncolytic virotherapy delivered by autologous mesenchymal stem cells: an exploratory study
[作者:Garcia-Castro, J; Alemany, R; Cascallo, M; Martinez-Quintanilla, J; Arriero, MD; Lassaletta, A; Madero, L; Ramirez, M,期刊:Cancer gene therapy, 页码:476-483 , 文章类型: Article,,卷期:2010年17-7]
- Treatment of metastatic tumors with engineered adenoviruses that replicate selectively in tumor cells is a new therapeutic approach in cancer. Systemic administration of these oncolytic adenoviruses lack metastatic targe...
- Potent antitumor effects of combined therapy with a telomerase-specific, replication-competent adenovirus (OBP-301) and IL-2 in a mouse model of renal cell carcinoma
[作者:Huang, P; Kaku, H; Chen, J; Kashiwakura, Y; Saika, T; Nasu, Y; Urata, Y; Fujiwara, T; Watanabe, M; Kumon, H,期刊:Cancer gene therapy, 页码:484-491 , 文章类型: Article,,卷期:2010年17-7]
- OBP-301 (a telomerase-specific, replication-competent adenovirus with hTERT promoter) was constructed in a previous study and it showed a strong anticancer effect by inducing cell lysis in human lung and prostate cancer ...
- Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation
[作者:Whelan, MC; Casey, G; MacConmara, M; Lederer, JA; Soden, D; Collins, JK; Tangney, M; O'Sullivan, GC,期刊:Cancer gene therapy, 页码:501-511 , 文章类型: Article,,卷期:2010年17-7]
- Obstacles to effective immunotherapeutic anti-cancer approaches include poor immunogenicity of the tumour cells and the presence of tolerogenic mechanisms in the tumour microenvironment. We report an effective immune-bas...
- Enhanced growth inhibition of metastatic lung tumors by intravenous injection of ATRA-cationic liposome/IL-12 pDNA complexes in mice
[作者:Charoensit, P; Kawakami, S; Higuchi, Y; Yamashita, F; Hashida, M,期刊:Cancer gene therapy, 页码:512-522 , 文章类型: Article,,卷期:2010年17-7]
- Interleukin 12 (IL-12) is a proinflammatory cytokine with antitumor activity. All-trans-retinoic acid (ATRA) exerts antitumor effects by regulating a variety of gene expressions, including tumor necrosis factor receptor ...
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