- Human pre-implantation embryo development
[作者：Niakan, KK; Han, JN; Pedersen, RA; Simon, C; Pera, RAR,期刊：Development, 页码：829-841 , 文章类型： Article，,卷期：2012年139-5]
- Understanding human pre-implantation development has important implications for assisted reproductive technology (ART) and for human embryonic stem cell (hESC)-based therapies. Owing to limited resources, the cellular an...
- Retinoic acid signalling during development
[作者：Rhinn, M; Dolle, P,期刊：Development, 页码：843-858 , 文章类型： Article，,卷期：2012年139-5]
- Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule that acts as ligand for nuclear RA receptors (RARs), converting them from transcriptional repressors to activators. The distribution and ...
- The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos
[作者：Kuijk, EW; van Tol, LTA; Van de Velde, H; Wubbolts, R; Welling, M; Geijsen, N; Roelen, BAJ,期刊：Development, 页码：871-882 , 文章类型： Article，,卷期：2012年139-5]
- At the blastocyst stage of mammalian pre-implantation development, three distinct cell lineages have formed: trophectoderm, hypoblast (primitive endoderm) and epiblast. The inability to derive embryonic stem (ES) cell li...
- The establishment of asymmetry in Arabidopsis lateral root founder cells is regulated by LBD16/ASL18 and related LBD/ASL proteins
[作者：Goh, T; Joi, S; Mimura, T; Fukaki, H,期刊：Development, 页码：883-893 , 文章类型： Article，,卷期：2012年139-5]
- In most dicot plants, lateral root (LR) formation, which is important for the construction of the plant root system, is initiated from coordinated asymmetric cell divisions (ACD) of the primed LR founder cells in the xyl...
- Cis-regulatory properties of medaka synexpression groups
[作者：Ramialison, M; Reinhardt, R; Henrich, T; Wittbrodt, B; Kellner, T; Lowy, CM; Wittbrodt, J,期刊：Development, 页码：917-928 , 文章类型： Article，,卷期：2012年139-5]
- During embryogenesis, tissue specification is triggered by the expression of a unique combination of developmental genes and their expression in time and space is crucial for successful development. Synexpression groups ...
- The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub
[作者：Trofka, A; Schwendinger-Schreck, J; Brend, T; Pontius, W; Emonet, T; Holley, SA,期刊：Development, 页码：940-947 , 文章类型： Article，,卷期：2012年139-5]
- Using in vitro and in vivo assays, we define a network of Her/Hes dimers underlying transcriptional negative feedback within the zebrafish segmentation clock. Some of the dimers do not appear to be DNA-binding, whereas t...
- SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton
[作者：Langdon, Y; Tandon, P; Paden, E; Duddy, J; Taylor, JM; Conlon, FL,期刊：Development, 页码：948-957 , 文章类型： Article，,卷期：2012年139-5]
- Noonan syndrome is one of the most common causes of human congenital heart disease and is frequently associated with missense mutations in the protein phosphatase SHP-2. Interestingly, patients with acute myelogenous leu...
- Musculin and TCF21 coordinate the maintenance of myogenic regulatory factor expression levels during mouse craniofacial development
[作者：Moncaut, N; Cross, JW; Siligan, C; Keith, A; Taylor, K; Rigby, PWJ; Carvajal, JJ,期刊：Development, 页码：958-967 , 文章类型： Article，,卷期：2012年139-5]
- The specification of the skeletal muscle lineage during craniofacial development is dependent on the activity of MYF5 and MYOD, two members of the myogenic regulatory factor family. In the absence of MYF5 or MYOD there i...
- Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120-catenin
[作者：Chacon-Heszele, MF; Ren, DD; Reynolds, AB; Chi, FL; Chen, P,期刊：Development, 页码：968-978 , 文章类型： Article，,卷期：2012年139-5]
- The vertebrate planar cell polarity (PCP) pathway consists of conserved PCP and ciliary genes. During development, the PCP pathway regulates convergent extension (CE) and uniform orientation of sensory hair cells in the ...
- Extracellular leucine-rich repeat proteins are required to organize the apical extracellular matrix and maintain epithelial junction integrity in C. elegans
[作者：Mancuso, VP; Parry, JM; Storer, L; Poggioli, C; Nguyen, KCQ; Hall, DH; Sundaram, MV,期刊：Development, 页码：979-990 , 文章类型： Article，,卷期：2012年139-5]
- Epithelial cells are linked by apicolateral junctions that are essential for tissue integrity. Epithelial cells also secrete a specialized apical extracellular matrix (ECM) that serves as a protective barrier. Some compo...
- Dual transcriptional activities of SIX proteins define their roles in normal and ectopic eye development
[作者：Anderson, AM; Weasner, BM; Weasner, BP; Kumar, JP,期刊：Development, 页码：991-1000 , 文章类型： Article，,卷期：2012年139-5]
- The SIX family of homeodomain-containing DNA-binding proteins play crucial roles in both Drosophila and vertebrate retinal specification. In flies, three such family members exist, but only two, Sine oculis (So) and Opti...
- Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specification
[作者：Schaub, C; Nagaso, H; Jin, H; Frasch, M,期刊：Development, 页码：1001-1012 , 文章类型： Article，,卷期：2012年139-5]
- Members of the T-Box gene family of transcription factors are important players in regulatory circuits that generate myogenic and cardiogenic lineage diversities in vertebrates. We show that during somatic myogenesis in ...
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