CD30 is a transmembrane receptor, selectively expressed on tumor cells of certain lymphatic malignancies, such as Hodgkin's lymphoma, and therefore a privileged target for anti-CD30 antibody-based immunotherapy. Howev...

Background: Recognition of the importance of apoptosis in atherosclerosis could lead to the development of new therapeutic strategies aimed at the reduction of apoptotic death. Many of the available therapeutic agents...

Background: The advent of genome sequencing has brought about an explosion in the content of sequence databases. To date, more than 70 mammalian genomes are or will be available. In the pharmaceutical context, this im...

Background: Over the last decade, the pharmaceutical industry has invested significantly in efforts to identify novel inhibitors of the mitogen-activated protein kinases MEK1 and MEK2. Unsurprisingly, several ATP-comp...

Background: The renin-angiotensin-aldosterone system (RAAS) is essential for the regulation of blood pressure and may play a critical role in the pathogenesis of cardiovascular diseases. A strong rationale suggests a ...

Background: Research on the development of bioceramics as controlled delivery systems of biologically active molecules for bone implant technologies exhibits two distinct approaches: i) drug delivery to treat bone inf...

Background: ELR+ chemokines interact with the CXCR2 receptor on neutrophils and other immune cells to induce chemotaxis. This event plays a key role in a large number of autoimmune diseases and thus antagonists of the...