- Angiotensin II-Inducible Smooth Muscle Cell Apoptosis Involves the Angiotensin II Type 2 Receptor, GATA-6 Activation, and FasL-Fas Engagement
[作者:Tan, NY; Li, JM; Stocker, R; Khachigian, LM,期刊:Circulation Research, 页码:422-U41 , 文章类型: Article,,卷期:2009年105-5]
- Rationale: Fas ligand (FasL)-mediated smooth muscle cell (SMC) apoptosis within the vulnerable plaque may lead to plaque instability and rupture, events that underlie myocardial infarction and stroke. Objective: The mole...
- Epicardium and Myocardium Separate From a Common Precursor Pool by Crosstalk Between Bone Morphogenetic Protein- and Fibroblast Growth Factor-Signaling Pathways
[作者:van Wijk, B; van den Berg, G; Abu-Issa, R; Barnett, P; van der Velden, S; Schmidt, M; Ruijter, JM; Kirby, ML; Moorman, AFM; van den Hoff, MJB,期刊:Circulation Research, 页码:431-U71 , 文章类型: Article,,卷期:2009年105-5]
- Rationale: The epicardium contributes to the majority of nonmyocardial cells in the adult heart. Recent studies have reported that the epicardium is derived from Nkx2.5-positive progenitors and can differentiate into car...
- Tbx20 Interacts With Smads to Confine Tbx2 Expression to the Atrioventricular Canal
[作者:Singh, R; Horsthuis, T; Farin, HF; Grieskamp, T; Norden, J; Petry, M; Wakker, V; Moorman, AFM; Christoffels, VM; Kispert, A,期刊:Circulation Research, 页码:442-U101 , 文章类型: Article,,卷期:2009年105-5]
- Rationale: T-box transcription factors play critical roles in the coordinated formation of the working chambers and the atrioventricular canal (AVC). Tbx2 patterns embryonic myocardial cells to form the AVC and suppresse...
- Chronic Endoplasmic Reticulum Stress Activates Unfolded Protein Response in Arterial Endothelium in Regions of Susceptibility to Atherosclerosis
[作者:Civelek, M; Manduchi, E; Riley, RJ; Stoeckert, CJ; Davies, PF,期刊:Circulation Research, 页码:453-U127 , 文章类型: Article,,卷期:2009年105-5]
- Rationale: Endothelial function and dysfunction are central to the focal origin and regional development of atherosclerosis; however, an in vivo endothelial phenotypic footprint of susceptibility to atherosclerosis prece...
- Heart-Infiltrating Prominin-1(+)/CD133(+) Progenitor Cells Represent the Cellular Source of Transforming Growth Factor beta-Mediated Cardiac Fibrosis in Experimental Autoimmune Myocarditis
[作者:Kania, G; Blyszczuk, P; Stein, S; Valaperti, A; Germano, D; Dirnhofer, S; Hunziker, L; Matter, CM; Eriksson, U,期刊:Circulation Research, 页码:462-U151 , 文章类型: Article,,卷期:2009年105-5]
- Rationale: Myocardial fibrosis is a hallmark of inflammation-triggered end-stage heart disease, a common cause of heart failure in young patients. Objective: We used CD4(+) T-cell-mediated experimental autoimmune myocard...
- Shear Stress Induces Synthetic-to-Contractile Phenotypic Modulation in Smooth Muscle Cells via Peroxisome Proliferator-Activated Receptor alpha/delta Activations by Prostacyclin Released by Sheared Endothelial Cells
[作者:Tsai, MC; Chen, LH; Zhou, J; Tang, ZH; Hsu, TF; Wang, Y; Shih, YT; Peng, HH; Wang, NP; Guan, YF; Chien, S; Chiu, JJ,期刊:Circulation Research, 页码:471-480 , 文章类型: Article,,卷期:2009年105-5]
- Rationale: Phenotypic modulation of smooth muscle cells (SMCs), which are located in close proximity to endothelial cells (ECs), is critical in regulating vascular function. The role of flow-induced shear stress in the m...
- Nicotinamide Phosphoribosyltransferase Regulates Cell Survival Through NAD(+) Synthesis in Cardiac Myocytes
[作者:Hsu, CP; Oka, S; Shao, D; Hariharan, N; Sadoshima, J,期刊:Circulation Research, 页码:481-U193 , 文章类型: Article,,卷期:2009年105-5]
- Rationale: NAD(+) acts not only as a cofactor for cellular respiration but also as a substrate for NAD(+)-dependent enzymes, such as Sirt1. The cellular NAD(+) synthesis is regulated by both the de novo and the salvage p...
- Using Lidocaine and Benzocaine to Link Sodium Channel Molecular Conformations to State-Dependent Antiarrhythmic Drug Affinity
[作者:Hanck, DA; Nikitina, E; McNulty, MM; Fozzard, HA; Lipkind, GM; Sheets, MF,期刊:Circulation Research, 页码:492-499 , 文章类型: Article,,卷期:2009年105-5]
- Rationale: Lidocaine and other antiarrhythmic drugs bind in the inner pore of voltage-gated Na channels and affect gating use-dependently. A phenylalanine in domain IV, S6 (Phe1759 in NaV1.5), modeled to face the inner p...
- Preventive Effects of Heregulin-beta(1) on Macrophage Foam Cell Formation and Atherosclerosis
[作者:Xu, G; Watanabe, T; Iso, Y; Koba, S; Sakai, T; Nagashima, M; Arita, S; Hongo, S; Ota, H; Kobayashi, Y; Miyazaki, A; Hirano, T,期刊:Circulation Research, 页码:500-U217 , 文章类型: Article,,卷期:2009年105-5]
- Rationale: Human heregulins, neuregulin-1 type I polypeptides that activate proliferation, differentiation, and survival of glial cells, neurons, and myocytes, are expressed in macrophage foam cells within human coronary...
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