- Interval Training Normalizes Cardiomyocyte Function, Diastolic Ca2+ Control, and SR Ca2+ Release Synchronicity in a Mouse Model of Diabetic Cardiomyopathy
[作者:Stolen, TO; Hoydal, MA; Kemi, OJ; Catalucci, D; Ceci, M; Aasum, E; Larsen, T; Rolim, N; Condorelli, G; Smith, GL; Wisloff, U,期刊:Circulation Research, 页码:527-U47 , 文章类型: Article,,卷期:2009年105-6]
- Rationale: In the present study we explored the mechanisms behind excitation-contraction (EC) coupling defects in cardiomyocytes from mice with type-2 diabetes (db/db). Objective: We determined whether 13 weeks of aerobi...
- NADPH Oxidase Nox2 Is Required for Hypoxia-Induced Mobilization of Endothelial Progenitor Cells
[作者:Schroder, K; Kohnen, A; Aicher, A; Liehn, EA; Buchse, T; Stein, S; Weber, C; Dimmeler, S; Brandes, RP,期刊:Circulation Research, 页码:537-U60 , 文章类型: Article,,卷期:2009年105-6]
- Rationale: Endothelial progenitor cells (EPCs, defined as sca-1(+)flk-1(+)lin(-) mononuclear blood cells) contribute to vascular repair. The role of hypoxia and reactive oxygen species (ROS) in mobilization and function ...
- Regular Feeding Plays an Important Role in Cholesterol Homeostasis Through the Liver Circadian Clock
[作者:Yamajuku, D; Okubo, S; Haruma, T; Inagaki, T; Okuda, Y; Kojima, T; Noutomi, K; Hashimoto, S; Oda, H,期刊:Circulation Research, 页码:545-U75 , 文章类型: Article,,卷期:2009年105-6]
- Rationale: Peripheral clock control and the relevance of the circadian rhythm to physiology and disease are major questions in mammalian circadian biology. Objective: We examined the physiological functions of the liver ...
- LIM Kinase 1 Promotes Endothelial Barrier Disruption and Neutrophil Infiltration in Mouse Lungs
[作者:Gorovoy, M; Han, JY; Pan, HY; Welch, E; Neamu, R; Jia, ZP; Predescu, D; Vogel, S; Minshall, RD; Ye, RD; Malik, AB; Voyno-Yasenetskaya, T,期刊:Circulation Research, 页码:549-U99 , 文章类型: Article,,卷期:2009年105-6]
- Rationale: Disruption of endothelial barrier function and neutrophil-mediated injury are two major mechanisms underlying the pathophysiology of sepsis-induced acute lung injury (ALI). Recently we reported that endotoxin ...
- Truncation of Titin's Elastic PEVK Region Leads to Cardiomyopathy With Diastolic Dysfunction
[作者:Granzier, HL; Radke, MH; Peng, J; Westermann, D; Nelson, OL; Rost, K; King, NMP; Yu, QL; Tschope, C; McNabb, M; Larson, DF; Labeit, S; Gotthardt, M,期刊:Circulation Research, 页码:557-U126 , 文章类型: Article,,卷期:2009年105-6]
- Rationale: The giant protein titin plays key roles in myofilament assembly and determines the passive mechanical properties of the sarcomere. The cardiac titin molecule has 2 mayor elastic elements, the N2B and the PEVK ...
- Heat Shock Protein 70 Enhances Vascular Bone Morphogenetic Protein-4 Signaling by Binding Matrix Gla Protein
[作者:Yao, YC; Watson, AD; Ji, S; Bostrom, KI,期刊:Circulation Research, 页码:575-U171 , 文章类型: Article,,卷期:2009年105-6]
- Rationale: Matrix Gla protein (MGP) is a calcification inhibitor, which binds and inhibits bone morphogenetic protein (BMP)-2 and -4. Objective: The objective was to determine whether MGP also binds other proteins, which...
- Loss of Cardiac microRNA-Mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure
[作者:Rao, PK; Toyama, Y; Chiang, HR; Gupta, S; Bauer, M; Medvid, R; Reinhardt, F; Liao, R; Krieger, M; Jaenisch, R; Lodish, HF; Blelloch, R,期刊:Circulation Research, 页码:585-594 , 文章类型: Article,,卷期:2009年105-6]
- Rationale: Heart failure is a deadly and devastating disease that places immense costs on an aging society. To develop therapies aimed at rescuing the failing heart, it is important to understand the molecular mechanisms...
- Platelet Kainate Receptor Signaling Promotes Thrombosis by Stimulating Cyclooxygenase Activation
[作者:Sun, H; Swaim, A; Herrera, JE; Becker, D; Becker, L; Srivastava, K; Thompson, LE; Shero, MR; Perez-Tamayo, A; Suktitipat, B; Mathias, R; Contractor, A; Faraday, N; Morrell, CN,期刊:Circulation Research, 页码:595-U200 , 文章类型: Article,,卷期:2009年105-6]
- Rationale: Glutamate is a major signaling molecule that binds to glutamate receptors including the ionotropic glutamate receptors; kainate (KA) receptor (KAR), the N-methyl-D-aspartate receptor, and the alpha-amino-3-hyd...
- Efficient Regulation of VEGF Expression by Promoter-Targeted Lentiviral shRNAs Based on Epigenetic Mechanism A Novel Example of Epigenetherapy
[作者:Turunen, MP; Lehtola, T; Heinonen, SE; Assefa, GS; Korpisalo, P; Girnary, R; Glass, CK; Vaisanen, S; Yla-Herttuala, S,期刊:Circulation Research, 页码:604-U220 , 文章类型: Article,,卷期:2009年105-6]
- Rationale: We studied a possibility that shRNAs can lead to transcriptional gene activation at the promoter level via epigenetic mechanism. Objective: The purpose of this study was to test the effects on vascular endothe...
- Loss of Plakophilin-2 Expression Leads to Decreased Sodium Current and Slower Conduction Velocity in Cultured Cardiac Myocytes
[作者:Sato, PY; Musa, H; Coombs, W; Guerrero-Serna, G; Patino, GA; Taffet, SM; Isom, LL; Delmar, M,期刊:Circulation Research, 页码:523-U33 , 文章类型: Article,,卷期:2009年105-6]
- Rationale: Plakophilin-2 (PKP2) is an essential component of the cardiac desmosome. Recent data show that it interacts with other molecules of the intercalated disc. Separate studies show preferential localization of the...
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