- Origin of Cardiac Fibroblasts and the Role of Periostin
[作者:Snider, P; Standley, KN; Wang, J; Azhar, M; Doetschman, T; Conway, SJ,期刊:Circulation Research, 页码:934-947 , 文章类型: Review,,卷期:2009年105-10]
- Cardiac fibroblasts are the most populous nonmyocyte cell type within the mature heart and are required for extracellular matrix synthesis and deposition, generation of the cardiac skeleton, and to electrically insulate ...
- Smooth Muscle Cell alpha(2)delta-1 Subunits Are Essential for Vasoregulation by Ca(V)1.2 Channels
[作者:Bannister, JP; Adebiyi, A; Zhao, GL; Narayanan, D; Thomas, CM; Feng, JY; Jaggar, JH,期刊:Circulation Research, 页码:948-955 , 文章类型: Article,,卷期:2009年105-10]
- Rationale: Voltage-dependent L-type (Ca(V)1.2) Ca2+ channels are a heteromeric complex formed from pore-forming alpha(1) and auxiliary alpha(2 delta) and beta subunits. Ca(V)1.2 channels are the principal Ca2+ influx pat...
- Role of Ca2+/Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy
[作者:Miller, CL; Oikawa, M; Cai, YJ; Wojtovich, AP; Nagel, DJ; Xu, XB; Xu, HD; Florio, V; Rybalkin, SD; Beavo, JA; Chen, YF; Li, JD; Blaxall, BC; Abe, J; Yan, C,期刊:Circulation Research, 页码:956-U59 , 文章类型: Article,,卷期:2009年105-10]
- Rationale: Cyclic nucleotide phosphodiesterases (PDEs) through the degradation of cGMP play critical roles in maintaining cardiomyocyte homeostasis. Ca2+/calmodulin (CaM)-activated cGMP-hydrolyzing PDE1 family may play a...
- Nitro-Fatty Acid Inhibition of Neointima Formation After Endoluminal Vessel Injury
[作者:Cole, MP; Rudolph, TK; Khoo, NKH; Motanya, UN; Golin-Bisello, F; Wertz, JW; Schopfer, FJ; Rudolph, V; Woodcock, SR; Bolisetty, S; Ali, MS; Zhang, JF; Chen, E; Agarwal, A; Freeman, BA; Bauer, PM,期刊:Circulation Research, 页码:965-U74 , 文章类型: Article,,卷期:2009年105-10]
- Rationale: Fatty acid nitroalkenes are endogenously generated electrophilic byproducts of nitric oxide and nitrite-dependent oxidative inflammatory reactions. Existing evidence indicates nitroalkenes support posttranslat...
- Induction of the CXC Chemokine Interferon-gamma-Inducible Protein 10 Regulates the Reparative Response Following Myocardial Infarction
[作者:Bujak, M; Dobaczewski, M; Gonzalez-Quesada, C; Xia, Y; Leucker, T; Zymek, P; Veeranna, V; Tager, AM; Luster, AD; Frangogiannis, NG,期刊:Circulation Research, 页码:973-983 , 文章类型: Article,,卷期:2009年105-10]
- Rationale: Interferon-gamma-inducible protein (IP)-10/CXCL10, an angiostatic and antifibrotic chemokine with an important role in T-cell trafficking, is markedly induced in myocardial infarcts, and may regulate the repar...
- Gene Therapy With the Angiogenic Cytokine Secretoneurin Induces Therapeutic Angiogenesis by a Nitric Oxide-Dependent Mechanism
[作者:Schgoer, W; Theurl, M; Jeschke, J; Beer, AGE; Albrecht, K; Gander, R; Rong, S; Vasiljevic, D; Egger, M; Wolf, AM; Frauscher, S; Koller, B; Tancevski, I; Patsch, JR; Schratzberger, P; Piza-Katzer, H; Ritsch, A; Bahlmann, FH; Fischer-Colbrie, R; Wolf, D; Kirchmair, R,期刊:Circulation Research, 页码:994-U141 , 文章类型: Article,,卷期:2009年105-10]
- Rationale: The neuropeptide secretoneurin induces angiogenesis and postnatal vasculogenesis and is upregulated by hypoxia in skeletal muscle cells. Objective: We sought to investigate the effects of secretoneurin on ther...
- Differential Healing After Sirolimus, Paclitaxel, and Bare Metal Stent Placement in Combination With Peroxisome Proliferator-Activator Receptor gamma Agonists Requirement for mTOR/Akt2 in PPAR gamma Activation
[作者:Finn, AV; John, M; Nakazawa, G; Polavarapu, R; Karmali, V; Xu, X; Cheng, Q; Davis, T; Raghunathan, C; Acampado, E; Ezell, T; Lajoie, S; Eppihimer, M; Kolodgie, FD; Virmani, R; Gold, HK,期刊:Circulation Research, 页码:1003-1012 , 文章类型: Article,,卷期:2009年105-10]
- Rationale: Sirolimus-eluting coronary stents (SESs) and paclitaxel-eluting coronary stents (PESs) are used to reduce restenosis but have different sites of action. The molecular targets of sirolimus overlap with those of...
- Deletion of Protein Tyrosine Phosphatase 1b Improves Peripheral Insulin Resistance and Vascular Function in Obese, Leptin-Resistant Mice via Reduced Oxidant Tone
[作者:Ali, MI; Ketsawatsomkron, P; de Chantemele, EJB; Mintz, JD; Muta, K; Salet, C; Black, SM; Tremblay, ML; Fulton, DJ; Marrero, MB; Stepp, DW,期刊:Circulation Research, 页码:1013-U172 , 文章类型: Article,,卷期:2009年105-10]
- Rationale: Obesity is a risk factor for cardiovascular dysfunction, yet the underlying factors driving this impaired function remain poorly understood. Insulin resistance is a common pathology in obese patients and has b...
- TRPC1 Channels Are Critical for Hypertrophic Signaling in the Heart
[作者:Seth, M; Zhang, ZS; Mao, L; Graham, V; Burch, J; Stiber, J; Tsiokas, L; Winn, M; Abramowitz, J; Rockman, HA; Birnbaumer, L; Rosenberg, P,期刊:Circulation Research, 页码:1023-U190 , 文章类型: Article,,卷期:2009年105-10]
- Rationale: Cardiac muscle adapts to increase workload by altering cardiomyocyte size and function resulting in cardiac hypertrophy. G protein-coupled receptor signaling is known to govern the hypertrophic response throug...
- Whole Body UVA Irradiation Lowers Systemic Blood Pressure by Release of Nitric Oxide From Intracutaneous Photolabile Nitric Oxide Derivates
[作者:Oplander, C; Volkmar, CM; Paunel-Gorgulu, A; van Faassen, EE; Heiss, C; Kelm, M; Halmer, D; Murtz, M; Pallua, N; Suschek, CV,期刊:Circulation Research, 页码:1031-U215 , 文章类型: Article,,卷期:2009年105-10]
- Rationale: Human skin contains photolabile nitric oxide derivates like nitrite and S-nitroso thiols, which after UVA irradiation, decompose and lead to the formation of vasoactive NO. Objective: Here, we investigated whe...
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