- Angiopoietin-2 Confers Atheroprotection in apoE(-/-) Mice by Inhibiting LDL Oxidation via Nitric Oxide
[作者:Ahmed, A; Fujisawa, T; Niu, XL; Ahmad, S; Al-Ani, B; Chudasama, K; Abbas, A; Potluri, R; Bhandari, V; Findley, CM; Lam, GKW; Huang, JH; Hewett, PW; Cudmore, M; Kontos, CD,期刊:Circulation Research, 页码:1333-U33 , 文章类型: Editorial Material,,卷期:2009年104-12]
- Atherosclerosis is promoted by a combination of hypercholesterolemia and vascular inflammation. The function of Angiopoietin (Ang)-2, a key regulator of angiogenesis, in the maintenance of large vessels is unknown. A sin...
- Milk Fat Globule Protein Epidermal Growth Factor-8 A Pivotal Relay Element Within the Angiotensin II and Monocyte Chemoattractant Protein-1 Signaling Cascade Mediating Vascular Smooth Muscle Cells Invasion
[作者:Fu, ZM; Wang, MY; Gucek, M; Zhang, J; Wu, J; Jiang, LQ; Monticone, RE; Khazan, B; Telljohann, R; Mattison, J; Sheng, SM; Cole, RN; Spinetti, G; Pintus, G; Liu, LJ; Kolodgie, FD; Virmani, R; Spurgeon, H; Ingram, DK; Everett, AD; Lakatta, EG; Van Eyk, JE,期刊:Circulation Research, 页码:1337-U177 , 文章类型: Review,,卷期:2009年104-12]
- Advancing age induces aortic wall thickening that results from the concerted effects of numerous signaling proteins, many of which have yet to be identified. To search for novel proteins associated with aortic wall thick...
- Positive Transcription Elongation Factor b Activity in Compensatory Myocardial Hypertrophy is Regulated by Cardiac Lineage Protein-1
[作者:Espinoza-Derout, J; Wagner, M; Salciccioli, L; Lazar, JM; Bhaduri, S; Mascareno, E; Chaqour, B; Siddiqui, MAQ,期刊:Circulation Research, 页码:1347-U189 , 文章类型: Article,,卷期:2009年104-12]
- Emerging evidence illustrates the importance of the positive transcription elongation factor (P-TEF) b in control of global RNA synthesis, which constitutes a major feature of the compensatory response to diverse hypertr...
- Lipoprotein Accumulation in Macrophages via Toll-Like Receptor-4-Dependent Fluid Phase Uptake
[作者:Choi, SH; Harkewicz, R; Lee, JH; Boullier, A; Almazan, F; Li, AC; Witztum, JL; Bae, YS; Miller, YI,期刊:Circulation Research, 页码:1355-U215 , 文章类型: Article,,卷期:2009年104-12]
- Toll-like receptor (TLR) 4 recognizes microbial pathogens, such as lipopolysaccharide, and mediates lipopolysaccharide-induced proinflammatory cytokine secretion, as well as microbial uptake by macrophages. In addition t...
- Accessory Subunit KChIP2 Modulates the Cardiac L-Type Calcium Current
[作者:Thomsen, MB; Wang, CJ; Ozgen, N; Wang, HG; Rosen, MR; Pitt, GS,期刊:Circulation Research, 页码:1382-U251 , 文章类型: Article,,卷期:2009年104-12]
- Complex modulation of voltage-gated Ca2+ currents through the interplay among Ca2+ channels and various Ca2+-binding proteins is increasingly being recognized. The K+ channel interacting protein 2 (KChIP2), originally id...
- Antiarrhythmic Drug-Induced Internalization of the Atrial-Specific K+ Channel Kv1.5
[作者:Schumacher, SM; McEwen, DP; Zhang, L; Arendt, KL; Van Genderen, KM; Martens, JR,期刊:Circulation Research, 页码:1390-U284 , 文章类型: Article,,卷期:2009年104-12]
- Conventional antiarrhythmic drugs target the ion permeability of channels, but increasing evidence suggests that functional ion channel density can also be modified pharmacologically. Kv1.5 mediates the ultrarapid potass...
- Synergistic Activation of Vascular TRPC6 Channel by Receptor and Mechanical Stimulation via Phospholipase C/Diacylglycerol and Phospholipase A(2)/omega-Hydroxylase/20-HETE Pathways
[作者:Inoue, R; Jensen, LJ; Jian, Z; Shi, J; Hai, L; Lurie, AI; Henriksen, FH; Salomonsson, M; Morita, H; Kawarabayashi, Y; Mori, M; Mori, Y; Ito, Y,期刊:Circulation Research, 页码:1399-1409 , 文章类型: Proceedings Paper,,卷期:2009年104-12]
- TRPC6 is a non-voltage-gated Ca2+ entry/depolarization channel associated with vascular tone regulation and remodeling. Expressed TRPC6 channel responds to both neurohormonal and mechanical stimuli, the mechanism for whi...
- Robust Functional Vascular Network Formation In Vivo by Cooperation of Adipose Progenitor and Endothelial Cells
[作者:Traktuev, DO; Prater, DN; Merfeld-Clauss, S; Sanjeevaiah, AR; Saadatzadeh, MR; Murphy, M; Johnstone, BH; Ingram, DA; March, KL,期刊:Circulation Research, 页码:1410-U320 , 文章类型: Article,,卷期:2009年104-12]
- Rapid induction and maintenance of blood flow through new vascular networks is essential for successfully treating ischemic tissues and maintaining function of engineered neo-organs. We have previously shown that human e...
- Apelin Gene Transfer Into the Rostral Ventrolateral Medulla Induces Chronic Blood Pressure Elevation in Normotensive Rats
[作者:Zhang, Q; Yao, FR; Raizada, MK; O'Rourke, ST; Sun, CW,期刊:Circulation Research, 页码:1421-U339 , 文章类型: Article,,卷期:2009年104-12]
- The peripheral apelin system plays a significant role in cardiovascular homeostasis and in the pathophysiology of cardiovascular diseases. However, the central effect of this neurohormonal system in neural control of car...
- Atheroprotective Effects of Alum Are Associated With Capture of Oxidized LDL Antigens and Activation of Regulatory T Cells
[作者:Wigren, M; Bengtsson, D; Duner, P; Olofsson, K; Bjorkbacka, H; Bengtsson, E; Fredrikson, GN; Nilsson, J,期刊:Circulation Research, 页码:E62-E70 , 文章类型: Article,,卷期:2009年104-12]
- The immune system represents a promising novel target for prevention of atherosclerosis. Several pilot vaccines that reduce atherosclerosis in experimental animals have been developed. The aluminum hydroxide adjuvant Alu...
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