- Nitric Oxide-Independent Vasodilator Rescues Heme-Oxidized Soluble Guanylate Cyclase From Proteasomal Degradation
[作者:Meurer, S; Pioch, S; Pabst, T; Opitz, N; Schmidt, PM; Beckhaus, T; Wagner, K; Matt, S; Gegenbauer, K; Geschka, S; Karas, M; Stasch, JP; Schmidt, HHHW; Muller-Esterl, W,期刊:Circulation Research, 页码:33-U91 , 文章类型: Article,,卷期:2009年105-1]
- Nitric oxide (NO) is an essential vasodilator. In vascular diseases, oxidative stress attenuates NO signaling by both chemical scavenging of free NO and oxidation and downregulation of its major intracellular receptor, t...
- Angiotensin II-Mediated Adaptive and Maladaptive Remodeling of Cardiomyocyte Excitation-Contraction Coupling
[作者:Gusev, K; Domenighetti, AA; Delbridge, LMD; Pedrazzini, T; Niggli, E; Egger, M,期刊:Circulation Research, 页码:42-U110 , 文章类型: Article,,卷期:2009年105-1]
- Cardiac hypertrophy is associated with alterations in cardiomyocyte excitation-contraction coupling (ECC) and Ca2+ handling. Chronic elevation of plasma angiotensin II (Ang II) is a major determinant in the pathogenesis ...
- Physical and Functional Interaction Between Calcineurin and the Cardiac L-Type Ca2+ Channel
[作者:Tandan, S; Wang, Y; Wang, TT; Jiang, N; Hall, DD; Hell, JW; Luo, X; Rothermel, BA; Hill, JA,期刊:Circulation Research, 页码:51-U141 , 文章类型: Article,,卷期:2009年105-1]
- The L-type Ca2+ channel (LTCC) is the major mediator of Ca2+ influx in cardiomyocytes, leading to both mechanical contraction and activation of signaling cascades. Among these Ca2+-activated cascades is calcineurin, a pr...
- Gene Expression Profiling of the Forming Atrioventricular Node Using a Novel Tbx3-Based Node-Specific Transgenic Reporter
[作者:Horsthuis, T; Buermans, HPJ; Brons, JF; Verkerk, AO; Bakker, ML; Wakker, V; Clout, DEW; Moorman, AFM; 't Hoen, PAC; Christoffels, VM,期刊:Circulation Research, 页码:61-U175 , 文章类型: Article,,卷期:2009年105-1]
- The atrioventricular (AV) node is a recurrent source of potentially life-threatening arrhythmias. Nevertheless, limited data are available on its developmental control or molecular phenotype. We used a novel AV nodal myo...
- The I kappa B Kinase beta/Nuclear Factor kappa B Signaling Pathway Protects the Heart From Hemodynamic Stress Mediated by the Regulation of Manganese Superoxide Dismutase Expression
[作者:Hikoso, S; Yamaguchi, O; Nakano, Y; Takeda, T; Omiya, S; Mizote, I; Taneike, M; Oka, T; Tamai, T; Oyabu, J; Uno, Y; Matsumura, Y; Nishida, K; Suzuki, K; Kogo, M; Hori, M; Otsu, K,期刊:Circulation Research, 页码:70-79 , 文章类型: Article,,卷期:2009年105-1]
- Cardiomyocyte death plays an important role in the pathogenesis of heart failure. The nuclear factor (NF)-kappa B signaling pathway regulates cell death, however, the effect of NF-kappa B pathway on cell death can vary i...
- Cardiac Muscle Ring Finger-1 Increases Susceptibility to Heart Failure In Vivo
[作者:Willis, MS; Schisler, JC; Li, L; Rodriguez, JE; Hilliard, EG; Charles, PC; Patterson, C,期刊:Circulation Research, 页码:80-U218 , 文章类型: Article,,卷期:2009年105-1]
- Muscle ring finger (MuRF) 1 is a muscle-specific protein implicated in the regulation of cardiac myocyte size and contractility. MuRF2, a closely related family member, redundantly interacts with protein substrates and h...
- IP3 Constricts Cerebral Arteries via IP3 Receptor-Mediated TRPC3 Channel Activation and Independently of Sarcoplasmic Reticulum Ca2+ Release (vol 102, pg 1118, 2008)
[作者:Xi, Q; Adebiyi, A; Zhao, G; Chapman, KE; Waters, CM; Hassid, A; Jaggar, JH,期刊:Circulation Research, 页码:E1-E1 , 文章类型: Correction,,卷期:2009年105-1]
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- Chloride Intracellular Channel-4 Is a Determinant of Native Collateral Formation in Skeletal Muscle and Brain
[作者:Chalothorn, D; Zhang, H; Smith, JE; Edwards, JC; Faber, JE,期刊:Circulation Research, 页码:89-U239 , 文章类型: Article,,卷期:2009年105-1]
- The capacity of the collateral circulation to lessen injury in occlusive vascular disease depends on the density and caliber of native (preexisting) collaterals, as well as their ability to outwardly remodel in ischemia....
- MIF Deficiency Reduces Chronic Inflammation in White Adipose Tissue and Impairs the Development of Insulin Resistance, Glucose Intolerance, and Associated Atherosclerotic Disease
[作者:Verschuren, L; Kooistra, T; Bernhagen, J; Voshol, PJ; Ouwens, DM; van Erk, M; de Vries-van der Weij, J; Leng, L; van Bockel, JH; van Dijk, KW; Fingerle-Rowson, G; Bucala, R; Kleemann, R,期刊:Circulation Research, 页码:99-U275 , 文章类型: Article,,卷期:2009年105-1]
- Chronic inflammation in white adipose tissue (WAT) is positively associated with obesity, insulin resistance (IR) and the development of type 2 diabetes. The proinflammatory cytokine MIF (macrophage migration inhibitory ...
- Avoidance of Transient Cardiomyopathy in Cardiomyocyte-Targeted Tamoxifen-Induced MerCreMer Gene Deletion Models
[作者:Koitabashi, N; Bedja, D; Zaiman, AL; Pinto, YM; Zhang, ML; Gabrielson, KL; Takimoto, E; Kass, DA,期刊:Circulation Research, 页码:12-U38 , 文章类型: Editorial Material,,卷期:2009年105-1]
- Cardiac myocyte targeted MerCreMer transgenic mice expressing tamoxifen-inducible Cre driven by the alpha-myosin heavy chain promoter are increasingly used to control gene expression in the adult heart. Here, we show tam...
- Activating Transcription Factor 3 Constitutes a Negative Feedback Mechanism That Attenuates Saturated Fatty Acid/Toll-Like Receptor 4 Signaling and Macrophage Activation in Obese Adipose Tissue
[作者:Suganami, T; Yuan, X; Shimoda, Y; Uchio-Yamada, K; Nakagawa, N; Shirakawa, I; Usami, T; Tsukahara, T; Nakayama, K; Miyamoto, Y; Yasuda, K; Matsuda, J; Kamei, Y; Kitajima, S; Ogawa, Y,期刊:Circulation Research, 页码:25-U73 , 文章类型: Article,,卷期:2009年105-1]
- Obese adipose tissue is markedly infiltrated by macrophages, suggesting that they may participate in the inflammatory pathways that are activated in obese adipose tissue. Evidence has suggested that saturated fatty acids...
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