- Dissociation of Pentameric to Monomeric C-Reactive Protein on Activated Platelets Localizes Inflammation to Atherosclerotic Plaques
[作者:Eisenhardt, SU; Habersberger, J; Murphy, A; Chen, YC; Woollard, KJ; Bassler, N; Qian, HW; von zur Muhlen, C; Hagemeyer, CE; Ahrens, I; Chin-Dusting, J; Bobik, A; Peter, K,期刊:Circulation Research, 页码:128-U55 , 文章类型: Article,,卷期:2009年105-2]
- C-reactive protein (CRP) is a predictor of cardiovascular risk. It circulates as a pentamer (pentameric CRP) in plasma. The in vivo existence of monomeric (m)CRP has been postulated, but its function and source are not c...
- Palmitoylation of ATP-Binding Cassette Transporter A1 Is Essential for Its Trafficking and Function
[作者:Singaraja, RR; Kang, MH; Vaid, K; Sanders, SS; Vilas, GL; Arstikaitis, P; Coutinho, J; Drisdel, RC; El-Husseini, AE; Green, WN; Berthiaume, L; Hayden, MR,期刊:Circulation Research, 页码:138-147 , 文章类型: Article,,卷期:2009年105-2]
- ATP-binding cassette transporter (ABC)A1 lipidates apolipoprotein A-I both directly at the plasma membrane and also uses lipids from the late endosomal or lysosomal compartment in the internal lipidation of apolipoprotei...
- An Unbiased Chemical Biology Screen Identifies Agents That Modulate Uptake of Oxidized LDL by Macrophages
[作者:Etzion, Y; Hackett, A; Proctor, BM; Ren, J; Nolan, B; Ellenberger, T; Muslin, AJ,期刊:Circulation Research, 页码:148-U91 , 文章类型: Article,,卷期:2009年105-2]
- Macrophage-derived foam cells are thought to play a major role in atherosclerotic lesion formation and progression. An automated assay was established to evaluate the uptake of fluorescently labeled oxidized low-density ...
- MicroRNA-145, a Novel Smooth Muscle Cell Phenotypic Marker and Modulator, Controls Vascular Neointimal Lesion Formation
[作者:Cheng, YH; Liu, XJ; Yang, J; Lin, Y; Xu, DZ; Lu, Q; Deitch, EA; Huo, YQ; Delphin, ES; Zhang, CX,期刊:Circulation Research, 页码:158-U113 , 文章类型: Article,,卷期:2009年105-2]
- Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a critical role in the pathogenesis of a variety of proliferative vascular diseases. Recently, we have found that microRNA (miRNA) miR-145 is the most a...
- L-Type Calcium Channel Blockers Exert an Antiinflammatory Effect by Suppressing Expression of Plasminogen Receptors on Macrophages
[作者:Das, R; Burke, T; Van Wagoner, DR; Plow, EF,期刊:Circulation Research, 页码:167-U137 , 文章类型: Article,,卷期:2009年105-2]
- L-type Ca2+ channel (LTCC) blockers, represented by amlodipine and verapamil, are widely used antihypertensive drugs that also have antiinflammatory activities. Plasminogen (Plg) is an important mediator of macrophage re...
- Novel Pharmacophores of Connexin43 Based on the "RXP" Series of Cx43-Binding Peptides
[作者:Verma, V; Larsen, BD; Coombs, W; Lin, XM; Spagnol, G; Sorgen, PL; Taffet, SM; Delmar, M,期刊:Circulation Research, 页码:176-U160 , 文章类型: Article,,卷期:2009年105-2]
- Gap junction pharmacology is a nascent field. Previous studies have identified molecules that enhance intercellular communication, and may offer potential for innovative antiarrhythmic therapy. However, their specific mo...
- Reversible Oxidative Modification A Key Mechanism of Na+-K+ Pump Regulation
[作者:Figtree, GA; Liu, CC; Bibert, S; Hamilton, EJ; Garcia, A; White, CN; Chia, KKM; Cornelius, F; Geering, K; Rasmussen, HH,期刊:Circulation Research, 页码:185-U187 , 文章类型: Article,,卷期:2009年105-2]
- Angiotensin II (Ang II) inhibits the cardiac sarcolemmal Na+-K+ pump via protein kinase (PK)C-dependent activation of NADPH oxidase. We examined whether this is mediated by oxidative modification of the pump subunits. We...
- Protein Kinase C alpha, but Not PKC beta or PKC gamma, Regulates Contractility and Heart Failure Susceptibility Implications for Ruboxistaurin as a Novel Therapeutic Approach
[作者:Liu, QH; Chen, XW; MacDonnell, SM; Kranias, EG; Lorenz, JN; Leitges, M; Houser, SR; Molkentin, JD,期刊:Circulation Research, 页码:194-200 , 文章类型: Article,,卷期:2009年105-2]
- Protein kinase (PK)C alpha, PKC beta, and PKC gamma comprise the conventional PKC isoform subfamily, which is thought to regulate cardiac disease responsiveness. Indeed, mice lacking the gene for PKC alpha show enhanced ...
- Angiomodulin Is a Specific Marker of Vasculature and Regulates Vascular Endothelial Growth Factor-A-Dependent Neoangiogenesis
[作者:Hooper, AT; Shmelkov, SV; Gupta, S; Milde, T; Bambino, K; Gillen, K; Goetz, M; Chavala, S; Baljevic, M; Murphy, AJ; Valenzuela, DM; Gale, NW; Thurston, G; Yancopoulos, GD; Vahdat, L; Evans, T; Rafii, S,期刊:Circulation Research, 页码:201-U215 , 文章类型: Article,,卷期:2009年105-2]
- Blood vessel formation is controlled by the balance between pro- and antiangiogenic pathways. Although much is known about the factors that drive sprouting of neovessels, the factors that stabilize and pattern neovessels...
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