- Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling
[作者：Calvert, JW; Jha, S; Gundewar, S; Elrod, JW; Ramachandran, A; Pattillo, CB; Kevil, CG; Lefer, DJ,期刊：Circulation Research, 页码：365-U105 , 文章类型： Article，,卷期：2009年105-4]
- Rationale: The recent emergence of hydrogen sulfide (H2S) as a potent cardioprotective signaling molecule necessitates the elucidation of its cytoprotective mechanisms. Objective: The present study evaluated potential me...
- Identification and Functional Characterization of Cardiac Troponin I As a Novel Disease Gene in Autosomal Dominant Dilated Cardiomyopathy
[作者：Carballo, S; Robinson, P; Otway, R; Fatkin, D; Jongbloed, JDH; de Jonge, N; Blair, E; van Tintelen, JP; Redwood, C; Watkins, H,期刊：Circulation Research, 页码：375-U116 , 文章类型： Article，,卷期：2009年105-4]
- Rationale: Idiopathic dilated cardiomyopathy (DCM) is inherited in approximately one third of cases, usually as an autosomal dominant trait. More than 30 loci have been identified, several of which encode sarcomeric prot...
- Nitric Oxide Increases Cardiac I-K1 by Nitrosylation of Cysteine 76 of Kir2.1 Channels
[作者：Gomez, R; Caballero, R; Barana, A; Amoros, I; Calvo, E; Lopez, JA; Klein, H; Vaquero, M; Osuna, L; Atienza, F; Almendral, J; Pinto, A; Tamargo, J; Delpon, E,期刊：Circulation Research, 页码：383-U151 , 文章类型： Article，,卷期：2009年105-4]
- Rationale: The cardiac inwardly rectifying K+ current (I-K1) plays a critical role in modulating excitability by setting the resting membrane potential and shaping phase 3 of the cardiac action potential. Objective: This...
- Induction of Transglutaminase 2 by a Liver X Receptor/Retinoic Acid Receptor alpha Pathway Increases the Clearance of Apoptotic Cells by Human Macrophages
[作者：Rebe, C; Raveneau, M; Chevriaux, A; Lakomy, D; Sberna, AL; Costa, A; Bessede, G; Athias, A; Steinmetz, E; Lobaccaro, JMA; Alves, G; Menicacci, A; Vachenc, S; Solary, E; Gambert, P; Masson, D,期刊：Circulation Research, 页码：393-401 , 文章类型： Article，,卷期：2009年105-4]
- Rationale: Liver X receptors (LXRs) are oxysterol-activated nuclear receptors that are involved in the control of cholesterol homeostasis and inflammatory response. Human monocytes and macrophages express high levels of ...
- CaMKII Negatively Regulates Calcineurin-NFAT Signaling in Cardiac Myocytes
[作者：MacDonnell, SM; Weisser-Thomas, J; Kubo, H; Hanscome, M; Liu, QH; Jaleel, N; Berretta, R; Chen, XW; Brown, JH; Sabri, AK; Molkentin, JD; Houser, SR,期刊：Circulation Research, 页码：316-U23 , 文章类型： Article，,卷期：2009年105-4]
- Rationale: Pathological cardiac myocyte hypertrophy is thought to be induced by the persistent increases in intracellular Ca2+ needed to maintain cardiac function when systolic wall stress is increased. Hypertrophic Ca2+...
- Adipocyte Fatty Acid-Binding Protein Suppresses Cardiomyocyte Contraction A New Link Between Obesity and Heart Disease
[作者：Lamounier-Zepter, V; Look, C; Alvarez, J; Christ, T; Ravens, U; Schunck, WH; Ehrhart-Bornstein, M; Bornstein, SR; Morano, I,期刊：Circulation Research, 页码：326-U34 , 文章类型： Article，,卷期：2009年105-4]
- Rationale: Adipocyte fatty acid-binding protein (FABP4) is a member of the intracellular lipid-binding protein family and is predominantly expressed in adipose tissue. Emerging evidence suggests that FABP4 plays a role i...
- Estrogen Contributes to Gender Differences in Mouse Ventricular Repolarization
[作者：Saito, T; Ciobotaru, A; Bopassa, JC; Toro, L; Stefani, E; Eghbali, M,期刊：Circulation Research, 页码：343-U72 , 文章类型： Article，,卷期：2009年105-4]
- Rationale: Fast-transient outward K+ (I-to,I-f) and ultrarapid delayed rectifier K+ currents (I-K,I-slow, also known as I-Kur) contribute to mouse cardiac repolarization. Gender studies on these currents have reported co...
- Differential Macrophage Polarization in Male and Female BALB/c Mice Infected With Coxsackievirus B3 Defines Susceptibility to Viral Myocarditis
[作者：Li, K; Xu, W; Guo, Q; Jiang, ZG; Wang, P; Yue, Y; Xiong, SD,期刊：Circulation Research, 页码：353-364 , 文章类型： Article，,卷期：2009年105-4]
- Rational: Myocardial infiltrating macrophages play an important role in the pathogenesis of viral myocarditis in male BALB/c mice following coxsackievirus B3 (CVB3) infection. Interestingly, comparable macrophage numbers...
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