- Amelioration of experimental autoimmune encephalomyelitis in IL-4R alpha(-/-) mice implicates compensatory up-regulation of Th2-type cytokines
[作者:Gaupp, S; Cannella, B; Raine, CS,期刊:American Journal of Pathology, 页码:119-129 , 文章类型: Article,,卷期:2008年173-1]
- The cytokine receptor interleukin (IL)-4R, expressed by lymphocytes, is well known for its role in immunomodulatory signaling and has also been documented on oligodendrocytes, suggesting involvement in glial cell interac...
- Fas-ligand-induced apoptosis of respiratory epithelial cells causes disruption of postcanalicular alveolar development
[作者:De Paepe, ME; Gundavarapu, S; Tantravahi, U; Pepperell, JR; Haley, SA; Luks, FI; Mao, QF,期刊:American Journal of Pathology, 页码:42-56 , 文章类型: Article,,卷期:2008年173-1]
- Premature infants are at risk for bronchopulmonary dysplasia, a complex condition characterized by impaired alveolar development and increased alveolar epithelial apoptosis. The functional involvement of pulmonary apopto...
- YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor
[作者:Bonneh-Barkay, D; Bissel, SJ; Wang, G; Fish, KN; Nicholl, GCB; Darko, SW; Medina-Flores, R; Murphey-Corb, M; Rajakumar, PA; Nyaundi, J; Mellors, JW; Bowser, R; Wiley, CA,期刊:American Journal of Pathology, 页码:130-143 , 文章类型: Article,,卷期:2008年173-1]
- Human immunodeficiency virus encephalitis causes dementia in acquired immune deficiency syndrome patients. Using proteomic analysis of postmortem cerebrospinal fluid (CSF) and brain tissue from the simian immunodeficienc...
- Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro
[作者:Lin, M; Jackson, P; Tester, AM; Diaconu, E; Overall, CM; Blalock, JE; Pearlman, E,期刊:American Journal of Pathology, 页码:144-153 , 文章类型: Article,,卷期:2008年173-1]
- matrix metalloproteinase (MMP)-8 and MMP-9 play several roles in inflammation, including degradation of extracellular matrix (ECM) components and regulation of cytokine activity. To determine the roles of MMP-8 and MMP-9...
- Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling
[作者:Bujak, M; Dobaczewski, M; Chatila, K; Mendoza, LH; Li, N; Reddy, A; Frangogiannis, NG,期刊:American Journal of Pathology, 页码:57-67 , 文章类型: Article,,卷期:2008年173-1]
- The proinflammatory cytokine interleukin (1L)-1 signals exclusively through the type I IL-1 receptor (IL-1RI). IL-1 expression is markedly induced in the infarcted heart; however, its role in cardiac injury and repair re...
- Suppression by CD4(+)CD25(+) regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells
[作者:George, JF; Braun, A; Brusko, TM; Joseph, R; Bolisetty, S; Wasserfall, CH; Atkinson, MA; Agarwal, A; Kapturczakt, MH,期刊:American Journal of Pathology, 页码:154-160 , 文章类型: Article,,卷期:2008年173-1]
- Heme oxygenase-1 (HO-1) has been viewed as a cytoprotective protein, ameliorating the effects of inflammatory cellular damage, and as beneficial in allograft protection from acute and chronic rejection, suggesting import...
- Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilage
[作者:Dejica, VM; Mort, JS; Laverty, S; Percival, MD; Antoniou, J; Zukor, DJ; Poole, AR,期刊:American Journal of Pathology, 页码:161-169 , 文章类型: Article,,卷期:2008年173-1]
- Cathepsin K is a cysteine protease of the papain family that cleaves triple-helical type II collagen, the major structural component of the extracellular matrix of articular cartilage. In osteoarthritis (OA), the anaboli...
- Absence of Smad3 induces neutrophil migration after cutaneous irradiation - Possible contribution to subsequent radioprotection
[作者:Flanders, KC; Ho, BM; Arany, PR; Stuelten, C; Mamura, M; Paterniti, MO; Sowers, A; Mitchell, JB; Roberts, AB,期刊:American Journal of Pathology, 页码:68-76 , 文章类型: Article,,卷期:2008年173-1]
- Our previous work showed that 6 weeks after cutaneous irradiation, mice null (knockout, KO) for Smad3, a cytoplasmic downstream mediator of transforming growth factor-beta, demonstrate less epidermal acanthosis and derma...
- Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke
[作者:Beck, H; Semisch, M; Culmsee, C; Plesnila, N; Hatzopoulos, AK,期刊:American Journal of Pathology, 页码:77-92 , 文章类型: Article,,卷期:2008年173-1]
- Ischemic brain injury causes tissue damage and neuronal death. The deficits can often be permanent because adult neurons fail to regenerate. One barrier to neuronal regeneration is the formation of the glial scar, a repa...
- Inhibition of proteasome activity promotes the correct localization of disease-causing alpha-sarcoglycan mutants in HEK-293 cells constitutively expressing beta-, gamma-, and delta-sarcoglycan
[作者:Gastaldello, S; D'Angelo, S; Franzoso, S; Fanin, M; Angelini, C; Betto, R; Sandona, D,期刊:American Journal of Pathology, 页码:170-181 , 文章类型: Article,,卷期:2008年173-1]
- Sarcoglycanopathies are progressive muscle-wasting disorders caused by genetic defects of four proteins, alpha-, beta-, gamma-, and delta-sarcoglycan, which are elements of a key transmembrane complex of striated muscle....
- Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappa B signaling
[作者:Giannopoulou, M; Dai, CS; Tan, XY; Wen, XY; Michalopoulos, GK; Liu, YH,期刊:American Journal of Pathology, 页码:30-41 , 文章类型: Article,,卷期:2008年173-1]
- Renal inflammation, characterized by the influx of inflammatory cells, is believed to play a critical role in the initiation and progression of a wide range of chronic kidney diseases. Here, we show that hepatocyte growt...
- CD4 T cells mediate axonal damage and spinal cord motor neuron apoptosis in murine P0(106-125)-induced experimental autoimmune neuritis
[作者:Brunn, A; Utermohlen, O; Carstov, M; Ruiz, MS; Miletic, H; Schluter, D; Deckert, M,期刊:American Journal of Pathology, 页码:93-105 , 文章类型: Article,,卷期:2008年173-1]
- The pathogenesis of inflammatory autoimmune diseases of the peripheral nervous system, leading to demyelination and/or axonal damage, remains incompletely understood. In particular, it is controversial regarding the exte...
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