- Adenoviral Overexpression and Small Interfering RNA Suppression Demonstrate That Plasminogen Activator Inhibitor-1 Produces Elevated Collagen Accumulation in Normal and Keloid Fibroblasts
[作者：Tuan, TL; Hwu, P; Ho, W; Yiu, P; Chang, R; Wysocki, A; Benya, PD,期刊：American Journal of Pathology, 页码：1311-1325 , 文章类型： Article，,卷期：2008年173-5]
- Keloids are tumor-like skin scars that grow as a result of the aberrant healing of skin injuries, with no effective treatment. We provide new evidence that both overexpression of plasminogen activator inhibitor-1 (PAI-1)...
- Inhibition of Nuclear Translocation of Apoptosis-Inducing Factor Is an Essential Mechanism of the Neuroprotective Activity of Pigment Epithelium-Derived Factor in a Rat Model of Retinal Degeneration
[作者：Murakami, Y; Ikeda, Y; Yonemitsu, Y; Onimaru, M; Nakagawa, K; Kohno, R; Miyazaki, M; Hisatomi, T; Nakamura, M; Yabe, T; Hasegawa, M; Ishibashi, T; Sueishi, K,期刊：American Journal of Pathology, 页码：1326-1338 , 文章类型： Article，,卷期：2008年173-5]
- Photoreceptor apoptosis is a critical process of retina degeneration in retinitis pigmentosa (RP), a group retinal degenerative diseases that result from rod and cone photoreceptor cell death and represent a major cause ...
- Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface
[作者：Mayer, JA; Foley, J; De La Cruz, D; Chuong, CM; Widelitz, R,期刊：American Journal of Pathology, 页码：1339-1348 , 文章类型： Article，,卷期：2008年173-5]
- Epithelial appendages, such as mammary glands and hair, arise as a result of epithelial-mesenchymal interactions. Bone morphogenetic proteins (BMPs) are important for hair follicle morphogenesis and cycling and are known...
- A Mutation in Rab38 Small GTPase Causes Abnormal Lung Surfactant Homeostasis and Aberrant Alveolar Structure in Mice
[作者：Osanai, K; Oikawa, R; Higuchi, J; Kobayashi, M; Tsuchihara, K; Iguchi, M; Jongsu, H; Toga, H; Voelker, DR,期刊：American Journal of Pathology, 页码：1265-1274 , 文章类型： Article，,卷期：2008年173-5]
- The chocolate mutation, which is associated with oculocutaneous albinism in mice, has been attributed to a G146T transversion in the conserved GTP/GDP-interacting domain of Rab38, a small GTPase that regulates intracellu...
- CGI-58 Is an alpha/beta-Hydrolase within Lipid Transporting Lamellar Granules of Differentiated Keratinocytes
[作者：Akiyama, M; Sakai, K; Takayama, C; Yanagi, T; Yamanaka, Y; McMillan, JR; Shimizu, H,期刊：American Journal of Pathology, 页码：1349-1360 , 文章类型： Article，,卷期：2008年173-5]
- CGI-58 is the causative molecule underlying Dorfman-Chanarin syndrome, a neutral lipid storage disease exhibiting apparent clinical features of ichthyosis. CGI-58, associated with triacylglycerol hydrolysis, has an alpha...
- Lipid Droplet-Associated Proteins Protect Renal Tubular Cells from Fatty Acid-Induced Apoptosis
[作者：Urahama, Y; Ohsaki, Y; Fujita, Y; Maruyama, S; Yuzawa, Y; Matsuo, S; Fujimoto, T,期刊：American Journal of Pathology, 页码：1286-1294 , 文章类型： Article，,卷期：2008年173-5]
- Proteinuria is a major cause of tubulointerstitial kidney damage, and free fatty acids bound to albumin are thought to play an important role in its pathogenesis. However, the mechanism whereby proteinuria causes tubuloi...
- Overexpression of mIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice
[作者：Semenova, E; Koegel, H; Hasse, S; Klatte, JE; Slonimsky, E; Bilbao, D; Paus, R; Werner, S; Rosenthal, N,期刊：American Journal of Pathology, 页码：1295-1310 , 文章类型： Article，,卷期：2008年173-5]
- Insulin-like growth factor 1 (IGF-1) is an important regulator of growth, survival, and differentiation in many tissues. It is produced in several isoforms; that differ in their N-terminal signal peptide and C-terminal e...
- Enhanced Integrated Stress Response Promotes Myelinating Oligodendrocyte Survival in Response to Interferon-gamma
[作者：Lin, WS; Kunkler, PE; Harding, HP; Ron, D; Kraig, RP; Popko, B,期刊：American Journal of Pathology, 页码：1508-1517 , 文章类型： Article，,卷期：2008年173-5]
- The T-cell-derived, pleiotropic cytokine interferon (IFN)-gamma is believed to play a key regulatory role in immune-mediated demyelinating disorders of the central nervous system, including multiple sclerosis and experim...
- Hyaluronan-Mediated Leukocyte Adhesion and Dextran Sulfate Sodium-Induced Colitis Are Attenuated in the Absence of Signal Transducer and Activator of Transcription 1
[作者：Bandyopadhyay, SK; de la Motte, CA; Kessler, SP; Hascall, VC; Hill, DR; Strong, SA,期刊：American Journal of Pathology, 页码：1361-1368 , 文章类型： Article，,卷期：2008年173-5]
- Inflammatory bowel disease is a chronic inflammatory condition of the intestinal mucosa whose etiology is unclear but is likely to be multifactorial. We have shown previously that an increased amount of hyaluronan (HA) i...
- Up-Regulation of Activating Transcription Factor-5 Suppresses SAP Expression to Activate T Cells in Hemophagocytic Syndrome Associated with Epstein-Barr Virus Infection and Immune Disorders
[作者：Chuang, HC; Wang, JM; Hsieh, WC; Chang, Y; Su, IJ,期刊：American Journal of Pathology, 页码：1397-1405 , 文章类型： Article，,卷期：2008年173-5]
- Hemophagocy-tic syndrome (HPS) is a fatal, pro-inflammatory cytokine disorder that is associated with viral infections and immune disorders. Previously, we demonstrated that Epstein-Barr virus latent membrane protein-1 (...
- Sall1, Sall2, and Sall4 Are Required for Neural Tube Closure in Mice
[作者：Bohm, J; Buck, A; Borozdin, W; Mannan, AU; Matysiak-Scholze, U; Adham, I; Schulz-Schaeffer, W; Floss, T; Wurst, W; Kohlhase, J; Barrionuevo, F,期刊：American Journal of Pathology, 页码：1455-1463 , 文章类型： Article，,卷期：2008年173-5]
- Four homologs; to the Drosophila homeotic gene spalt (sat) exist in both humans and mice (SALL1 to SALL4/Sall1 to Sall4, respectively). Mutations in both SALL1 and SALL4 result in the autosomal-dominant developmental dis...
- Specific Mutations in the beta-Catenin Gene (CTNNB1) Correlate with Local Recurrence in Sporadic Desmoid Tumors
[作者：Lazar, AJF; Tuvin, D; Hajibashi, S; Habeeb, S; Bolshakov, S; Mayordomo-Aranda, E; Warneke, CL; Lopez-Terrada, D; Pollock, RE; Lev, D,期刊：American Journal of Pathology, 页码：1518-1527 , 文章类型： Article，,卷期：2008年173-5]
- Desmoid fibromatosis is a rare, nonmetastatic neoplasm marked by local invasiveness and relentless recurrence. Molecular determinants of desmoid recurrence remain obscure. beta-Catenin deregulation has been commonly iden...
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