- Paradoxical Coupling of Triglyceride Synthesis and Fatty Acid Oxidation in Skeletal Muscle Overexpressing DGAT1
[作者：Liu, L; Shi, XJ; Choi, CS; Shulman, GI; Klaus, K; Nair, KS; Schwartz, GJ; Zhang, YY; Goldberg, IJ; Yu, YH,期刊：Diabetes, 页码：2516-2524 , 文章类型： Article，,卷期：2009年58-11]
- OBJECTIVE-Transgenic expression of diacylglycerol acyltransferase-1 (DGAT1) in skeletal muscle leads to protection against fat-induced insulin resistance despite accumulation of intramuscular triglyceride, a phenomenon s...
- Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart
[作者：Ko, HJ; Zhang, ZY; Jung, DY; Jun, JY; Ma, ZX; Jones, KE; Chan, SY; Kim, JK,期刊：Diabetes, 页码：2536-2546 , 文章类型： Article，,卷期：2009年58-11]
- OBJECTIVE-Heart failure is a major cause of mortality in diabetes and may be causally associated with altered metabolism. Recent reports indicate a role of inflammation in peripheral insulin resistance, but the impact of...
- Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle
[作者：Hong, EG; Ko, HJ; Cho, YR; Kim, HJ; Ma, ZX; Yu, TY; Friedline, RH; Kurt-Jones, E; Finberg, R; Fischer, MA; Granger, EL; Norbury, CC; Hauschka, SD; Philbrick, WM; Lee, CG; Elias, JA; Kim, JK,期刊：Diabetes, 页码：2525-2535 , 文章类型： Article，,卷期：2009年58-11]
- OBJECTIVE-Insulin resistance is a major characteristic of type 2 diabetes and is causally associated with obesity. Inflammation plays an important role in obesity-associated insulin resistance, but the underlying mechani...
- The microRNA Signature in Response to Insulin Reveals Its Implication in the Transcriptional Action of Insulin in Human Skeletal Muscle and the Role of a Sterol Regulatory Element-Binding Protein-1c/Myocyte Enhancer Factor 2C Pathway
[作者：Granjon, A; Gustin, MP; Rieusset, J; Lefai, E; Meugnier, E; Guller, I; Cerutti, C; Paultre, C; Disse, E; Rabasa-Lhoret, R; Laville, M; Vidal, H; Rome, S,期刊：Diabetes, 页码：2555-2564 , 文章类型： Article，,卷期：2009年58-11]
- OBJECTIVE-Factors governing microRNA expressions in response to changes of cellular environment are still largely unknown. Our aim was to determine whether insulin, the major hormone controlling whole-body energy homeost...
- Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent Potent Tissue-Specific Effects of Medium-Chain Fatty Acids
[作者：Turner, N; Hariharan, K; TidAng, J; Frangioudakis, G; Beale, SM; Wright, LE; Zeng, XY; Leslie, SJ; Li, JY; Kraegen, EW; Cooney, GJ; Ye, JM,期刊：Diabetes, 页码：2547-2554 , 文章类型： Article，,卷期：2009年58-11]
- OBJECTIVE-Medium-chain fatty acids (MCFAs) have been reported to be less obesogenic than long-chain fatty acids (LCFAs); however, relatively little is known regarding their effect on insulin action. Here, we examined the...
- Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice
[作者：Fujisaka, S; Usui, I; Bukhari, A; Ikutani, M; Oya, T; Kanatani, Y; Tsuneyama, K; Nagai, Y; Takatsu, K; Urakaze, M; Kobayashi, M; Tobe, K,期刊：Diabetes, 页码：2574-2582 , 文章类型： Article，,卷期：2009年58-11]
- OBJECTIVE-To characterize the phenotypic changes of adipose tissue macrophages (ATMs) under different conditions of insulin sensitivity. RESEARCH DESIGN AND METHODS-The number and the expressions of marker genes for M1 a...
- Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure
[作者：Seo, J; Fortuno, ES; Suh, JM; Stenesen, D; Tang, W; Parks, EJ; Adams, CM; Townes, T; Graff, JM,期刊：Diabetes, 页码：2565-2573 , 文章类型： Article，,卷期：2009年58-11]
- OBJECTIVE-We evaluate a potential role of activating transcription factor 4 (Atf4) in invertebrate and mammalian metabolism. RESEARCH DESIGN AND METHODS-With two parallel approaches-a fat body-specific green fluorescent ...
- Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes
[作者：Herold, KC; Brooks-Worrell, B; Palmer, J; Dosch, HM; Peakman, M; Gottlieb, P; Reijonen, H; Arif, S; Spain, LM; Thompson, C; Lachin, JM,期刊：Diabetes, 页码：2588-2595 , 文章类型： Article，,卷期：2009年58-11]
- OBJECTIVE-Type 1 diabetes results from an immune-mediated destruction of P-cells, likely to be mediated by T lymphocytes, but the sensitivity, specificity, and other measures of validity of existing assays for islet auto...
- Brown Adipose Tissue and Seasonal Variation in Humans
[作者：Au-Yong, ITH; Thorn, N; Ganatra, R; Perkins, AC; Symonds, ME,期刊：Diabetes, 页码：2583-2587 , 文章类型： Article，,卷期：2009年58-11]
- OBJECTIVE-Brown adipose tissue (BAT) is present in adult humans where it may be important in the prevention of obesity, although the main factors regulating its abundance are not well established. BAT demonstrates season...
- Metabolomics Applied to Diabetes Research Moving From Information to Knowledge
[作者：Bain, JR; Stevens, RD; Wenner, BR; Ilkayeva, O; Muoio, DM; Newgard, CB,期刊：Diabetes, 页码：2429-2443 , 文章类型： Article，,卷期：2009年58-11]
- Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets
[作者：Alquier, T; Peyot, ML; Latour, MG; Kebede, M; Sorensen, CM; Gesta, S; Kahn, CR; Smith, RD; Jetton, TL; Metz, TO; Prentki, M; Poitout, V,期刊：Diabetes, 页码：2607-2615 , 文章类型： Article，,卷期：2009年58-11]
- OBJECTIVE-The G-protein-coupled receptor GPR40 mediates fatty acid potentiation of glucose-stimulated insulin secretion, but its contribution to insulin secretion in vivo and mechanisms of action remain uncertain. This s...
- Expression of the NH2-Terminal Fragment of RasGAP in Pancreatic beta-Cells Increases Their Resistance to Stresses and Protects Mice From Diabetes
[作者：Yang, JY; Walicki, J; Jaccard, E; Dubuis, G; Bulat, N; Hornung, JP; Thorens, B; Widmann, C,期刊：Diabetes, 页码：2596-2606 , 文章类型： Article，,卷期：2009年58-11]
- OBJECTIVE-Our laboratory has previously established in vitro that a caspase-generated RasGAP NH2-terminal moiety, called fragment N, potently protects cells, including insulinomas, from apoptotic stress. We aimed to dete...
- FoxO1 Links Insulin Resistance to Proinflammatory Cytokine IL-1 beta Production in Macrophages
[作者：Su, DM; Coudriet, GM; Kim, DH; Lu, Y; Perdomo, G; Qu, S; Slusher, S; Tse, HM; Piganelli, J; Giannoukakis, N; Zhang, J; Dong, HH,期刊：Diabetes, 页码：2624-2633 , 文章类型： Article，,卷期：2009年58-11]
- OBJECTIVE-Macrophages play an important role in the pathogenesis of insulin resistance via the production of proinflammatory cytokines. Our goal is to decipher the molecular linkage between proinflammatory cytokine produ...
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