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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   Do microRNAs regulate bone marrow stem cell niche physiology? [作者：Laine, SK; Hentunen, T; Laitala-Leinonen, T,期刊：Gene, 页码：1-9 , 文章类型： Review，,卷期：2012年497-1] The adult bone marrow, situated within the bone cavity, comprises three distinct stem cell populations: hematopoietic stem cells (HSCs), mesenchymal stromal/stem cells (MSCs) and endothelial progenitor/stem cells (EPCs).... Instruction of mesenchymal cell fate by the transcription factor C/EBP beta [作者：Smink, JJ; Leutz, A,期刊：Gene, 页码：10-17 , 文章类型： Review，,卷期：2012年497-1] The transcription factor CCAAT/enhancer binding protein beta (C/EBP beta) plays a role in the differentiation of a large variety of cell types. C/EBP beta was initially described as an early inducer of adipocyte differen... CUX1 transcription factors: From biochemical activities and cell-based assays to mouse models and human diseases [作者：Hulea, L; Nepveu, A,期刊：Gene, 页码：18-26 , 文章类型： Review，,卷期：2012年497-1] ChIP-chip and expression analyses indicated that CUX1 transcription factors regulate a large number of genes and microRNAs involved in multiple cellular processes. Indeed, in proliferating cells CUX1 was shown to regulat... KlRox1p contributes to yeast resistance to metals and is necessary for KlYCF1 expression in the presence of cadmium [作者：Torres, AMR; Maceiras, ML; Belmonte, ER; Naveira, LN; Calvo, MB; Cerdan, ME,期刊：Gene, 页码：27-37 , 文章类型： Article，,卷期：2012年497-1] We have characterized the KIROX1 gene from Kluyveromyces lactis and verified that it does not regulate the hypoxic response in this yeast, oppositely to the Saccharomyces cerevisioe homologue ScROX1. The KIROX1 promoter ... The R453Q and D151A polymorphisms of Hexose-6-Phosphate Dehydrogenase Gene (H6PD) influence the polycystic ovary syndrome (PCOS) and obesity [作者：Martinez-Garcia, MA; San-Millan, JL; Escobar-Morreale, HF,期刊：Gene, 页码：38-44 , 文章类型： Article，,卷期：2012年497-1] Hexose-6-phosphate dehydrogenase (H6PDH) influences 11 beta-hydroxysteroid dehydrogenase activity, a key enzyme in the peripheral metabolism of cortisol that modulates insulin sensitivity in adipose tissue. To study the ... Loss of the Prader-Willi obesity syndrome protein necdin promotes adipogenesis [作者：Bush, JR; Wevrick, R,期刊：Gene, 页码：45-51 , 文章类型： Article，,卷期：2012年497-1] We investigated the role of necdin during adipogenic differentiation. Necdin is one of several genes inactivated in children with Prader-Willi syndrome, who are predisposed to increased adiposity at the expense of lean m... The evolution of MHC diversity: Evidence of intralocus gene conversion and recombination in a single-locus system [作者：Bahr, A; Wilson, AB,期刊：Gene, 页码：52-57 , 文章类型： Article，,卷期：2012年497-1] Gene conversion, the unidirectional exchange of genetic material between homologous sequences, is thought to strongly influence patterns of genetic diversity. The high diversity of major histocompatibility complex (MHC) ... Calculating phenotypic similarity between genes using hierarchical structure data based on semantic similarity [作者：Zhang, SZ; Chang, ZQ; Li, ZQ; DuanMu, HZ; Li, ZH; Li, KN; Liu, YF; Qiu, FJ; Xu, Y,期刊：Gene, 页码：58-65 , 文章类型： Article，,卷期：2012年497-1] Phenotypic similarity is correlated with a number of measures of gene function, such as relatedness at the level of direct protein-protein interaction. The phenotypic effect of a deleted or mutated gene, which is one par... A 40-bp insertion/deletion polymorphism in the constitutive promoter of MDM2 confers risk for hepatocellular carcinoma in a Chinese population [作者：Dong, D; Gao, XR; Zhu, ZS; Yu, Q; Bian, SZ; Gao, YZ,期刊：Gene, 页码：66-70 , 文章类型： Article，,卷期：2012年497-1] The pathogenesis of HCC is a multistage process with the involvement of genetic factors. The aim of the present study is to investigate the possible association between a 40-bp insertion/deletion polymorphism (indel) at ... Analysis of the role of p38 MAP kinase in epidermal growth factor-induced JB6 Cl41 cell transformation by cDNA array [作者：He, ZW; Cui, P; Ye, CG; Ma, WY; Bode, A; Dong, ZG,期刊：Gene, 页码：71-78 , 文章类型： Article，,卷期：2012年497-1] To further explore the mechanism of p38 MAP kinase in regulation of JB6 C cell transformation. cDNA array was employed to scan the differential expression genes between DN-p38 cells and CMV-neo JB6 Cl41 cells after EGF s... DAG1, no gene for RNA regulation? [作者：Brancaccio, A,期刊：Gene, 页码：79-82 , 文章类型： Article，,卷期：2012年497-1] DAG1 encodes for a precursor protein that liberates the two subunits featured by the dystroglycan (DG) adhesion complex that are involved in an increasing number of cellular functions in a wide variety of cells and tissu... Does the growth temperature of a prokaryote influence the purine content of its mRNAs? [作者：Mahale, KN; Kempraj, V; Dasgupta, D,期刊：Gene, 页码：83-89 , 文章类型： Article，,卷期：2012年497-1] The formation and breaking of hydrogen bonds between nucleic acid bases are dependent on temperature. The high G + C content of organisms was surmised to be an adaptation for high temperature survival because of the ther... A large deletion causes apparent homozygosity for the D1152H mutation in the cystic fibrosis transmembrane regulator (CFTR) gene [作者：Diana, A; Tesse, R; Polizzi, AM; Santostasi, T; Manca, A; Leonetti, G; Seia, M; Porcaro, L; Cavallo, L,期刊：Gene, 页码：90-92 , 文章类型： Article，,卷期：2012年497-1] We report the case of a patient with an apparent homozygosity for the D1152H mutation located in exon 18 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The parents had no personal history of cyst... Association between C3orf21, TP63 polymorphisms and environment and NSCLC in never-smoking Chinese population [作者：Zhang, YJ; Gu, CP; Shi, H; Zhang, AQ; Kong, XM; Bao, WL; Deng, DH; Ren, LL; Gu, DL,期刊：Gene, 页码：93-97 , 文章类型： Article，,卷期：2012年497-1] Recently, two genome-wide association studies in Asia identified gene polymorphisms known as rs4488809, rs9816619 in TP63 and rs2131877, rs952481 in C3orf21. It has been proposed that these polymorphisms are susceptibili... Polymorphisms of the insulin-like growth factor-binding protein 3 gene (IGFBP3) in gayal (Bos frontalis) [作者：Xi, DM; Wu, M; Fan, YY; Liu, Q; Leng, J; Gou, X; Mao, HM; Deng, WD,期刊：Gene, 页码：98-102 , 文章类型： Article，,卷期：2012年497-1] The gene coding for insulin-like growth factor-binding protein 3 (IGFBP3) is important for regulation of growth, development and metabolism in mammals. The present investigation was conducted to study nucleotide polymorp... Comparative analysis of the structural and expressional parameters of microRNA target genes [作者：Mok, YJ; Park, SG; Choi, SS,期刊：Gene, 页码：103-109 , 文章类型： Article，,卷期：2012年497-1] MicroRNAs (miRNAs) generally pair with the 3'UTRs of their target mRNAs to repress gene expression. It has reported that miRNA targets (TGs) are longer and evolve more slowly than non-targets (NTGs). We confirmed the obs...