- Lipid-Protein Correlations in Nanoscale Phospholipid Bilayers Determined by Solid-State Nuclear Magnetic Resonance
[作者:Kijac, A; Shih, AY; Nieuwkoop, AJ; Schulten, K; Sligar, SG; Rienstra, CM,期刊:Biochemistry, 页码:9190-9198 , 文章类型: Article,,卷期:2010年49-43]
- Nanodiscs are examples of discoidal nanoscale lipid protein particles that have been extremely useful for the biochemical and biophysical characterization of membrane proteins. They are discoidal lipid bilayer fragments ...
- Distance Measurements within a Concatamer of the Plasma Membrane Cl-/HCO3- Exchanger, AEl
[作者:Basu, A; Mazor, S; Casey, JR,期刊:Biochemistry, 页码:9226-9240 , 文章类型: Article,,卷期:2010年49-43]
- AEI, which exists in the erythrocyte plasma membrane as a noncovalent dimer, facilitates transmembrane Cl-/HCO3- exchange. Here a concatamer of AEI (two AEI monomers fused via a two-residue linker to form an intramolecul...
- Acetylation of GAGA Factor Modulates Its Interaction with DNA
[作者:Aran-Guiu, X; Ortiz-Lombardia, M; Oliveira, E; Costa, CB; Odena, MA; Bellido, D; Bernues, J,期刊:Biochemistry, 页码:9140-9151 , 文章类型: Article,,卷期:2010年49-43]
- GAGA is a Drosophila transcription factor that shows a high degree of post-translational modification. Here, we show that GAGA factor is acetylated in vivo. Lysine residues K325 and K373 on basic regions BR I and BR3 of ...
- Correlation of Charge, Hydrophobicity, and Structure with Antimicrobial Activity of S1 and MIRIAM Peptides
[作者:Leptihn, S; Har, JY; Wohland, T; Ding, JL,期刊:Biochemistry, 页码:9161-9170 , 文章类型: Article,,卷期:2010年49-43]
- Antimicrobial peptides are key elements of the innate immune system. Many of them interact with membranes of bacteria leading to perturbation of the lipid bilayer and eventually to inactivation of the pathogen. The emerg...
- Sensing DNA Opening in Transcription Using Quenchable Forster Resonance Energy Transfer
[作者:Cordes, T; Santoso, Y; Tomescu, AI; Gryte, K; Hwang, LC; Camara, B; Wigneshweraraj, S; Kapanidis, AN,期刊:Biochemistry, 页码:9171-9180 , 文章类型: Article,,卷期:2010年49-43]
- Many biological processes, such as gene transcription and replication, involve opening and closing of short regions of double-stranded DNA (dsDNA). Few techniques, however, can study these processes in real time or at th...
- Analysis of Adenosine A(2)a Receptor Stability: Effects of Ligands and Disulfide Bonds
[作者:O'Malley, MA; Naranjo, AN; Lazarova, T; Robinson, AS,期刊:Biochemistry, 页码:9181-9189 , 文章类型: Article,,卷期:2010年49-43]
- G protein-coupled receptors (GPCRs) constitute the largest family of integral membrane proteins present in all eukaryotic cells, yet relatively little information about their structure, folding, and stability has been pu...
- Assessing Energetic Contributions to Binding from a Disordered Region in a Protein-Protein Interaction
[作者:Cho, S; Swaminathan, CP; Bonsor, DA; Kerzic, MC; Guan, R; Yang, JY; Kieke, MC; Andersen, PS; Kranz, DM; Mariuzza, RA; Sundberg, EJ,期刊:Biochemistry, 页码:9256-9268 , 文章类型: Article,,卷期:2010年49-43]
- Many functional proteins are at least partially disordered prior to binding. Although the structural transitions upon binding of disordered protein regions can influence the affinity and specificity of protein complexes,...
- Structural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine Selectivity
[作者:Weeks, AM; Coyle, SM; Jinek, M; Doudna, JA; Chang, MCY,期刊:Biochemistry, 页码:9269-9279 , 文章类型: Article,,卷期:2010年49-43]
- We have initiated a broad-based program aimed at understanding the molecular basis of fluorine specificity in enzymatic systems, and in this context, we report crystallographic and biochemical studies on a fluoroacetyl-c...
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