- Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase
[作者:Gao, XF; Li, K; Hui, XY; Kong, XP; Sweeney, G; Wang, Y; Xu, AM; Teng, MK; Liu, PT; Wu, DH,期刊:Biochemical Journal, 页码:723-732 , 文章类型: Article,,卷期:2011年435-Part 3]
- The adipocyte is the principal cell type for fat storage. CPT1 (carnitine palmitoyltransferase-1) is the rate-limiting enzyme for fatty acid beta-oxidation, but the physiological role of CPT1 in adipocytes remains unclea...
- Recombinant Deg/HtrA proteases from Synechocystis sp PCC 6803 differ in substrate specificity, biochemical characteristics and mechanism
[作者:Huesgen, PF; Miranda, H; Lam, X; Perthold, M; Schuhmann, H; Adamska, I; Funk, C,期刊:Biochemical Journal, 页码:733-742 , 文章类型: Article,,卷期:2011年435-Part 3]
- Cyanobacteria require efficient protein-quality-control mechanisms to survive under dynamic, often stressful, environmental conditions. It was reported that three serine proteases, HtrA (high temperature requirement A), ...
- A composite biochemical system for bacterial nitrate and nitrite assimilation as exemplified by Paracoccus denitrificans
[作者:Gates, AJ; Luque-Almagro, VM; Goddard, AD; Ferguson, SJ; Roldan, MD; Richardson, DJ,期刊:Biochemical Journal, 页码:743-753 , 文章类型: Article,,卷期:2011年435-Part 3]
- The denitrifying bacterium Paracoccus denitrificans can grow aerobically or anaerobically using nitrate or nitrite as the sole nitrogen source. The biochemical pathway responsible is expressed from a gene cluster compris...
- Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation
[作者:MacKenzie, KF; Wallace, DA; Hill, EV; Anthony, DF; Henderson, DJP; Houslay, DM; Arthur, JSC; Baillie, GS; Houslay, MD,期刊:Biochemical Journal, 页码:755-769 , 文章类型: Article,,卷期:2011年435-Part 3]
- cAMP-specific PDE (phosphodiesterase) 4 isoforms underpin compartmentalized cAMP signalling in mammalian cells through targeting to specific signalling complexes. Their importance is apparent as PDE4 selective inhibitors...
- Domain interactions of the transcription-translation coupling factor Escherichia coli NusG are intermolecular and transient
[作者:Burmann, BM; Scheckenhofer, U; Schweimer, K; Rosch, P,期刊:Biochemical Journal, 页码:783-789 , 文章类型: Article,,卷期:2011年435-Part 3]
- The bacterial transcription factor NusG (N-utilization substance G) is suggested to act as a key coupling factor between transcription and translation [Burmann, Schweimer, Luo, Wahl, Stitt, Gottesman and Rosch (2010) Sci...
- Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP2 hydrolysis activity of sperm PLC zeta (vol 434, pg 211, 2011)
[作者:Nomikos, M; Elgmati, K; Theodoridou, M; Calver, BL; Cumbes, B; Nounesis, G; Swann, K; Lai, FA,期刊:Biochemical Journal, 页码:791-791 , 文章类型: Correction,,卷期:2011年435-Part 3]
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- TFCP2c/LSF/LBP-1c is required for Snail1-induced fibronectin gene expression
[作者:Porta-de-la-Riva, M; Stanisavljevic, J; Curto, J; Franci, C; Diaz, VM; de Herreros, AG; Baulida, J,期刊:Biochemical Journal, 页码:563-568 , 文章类型: Article,,卷期:2011年435-Part 3]
- Fibronectins are cell-secreted glycoproteins that modulate cell attachment, spreading, migration, morphology, differentiation and oncogenic transformation. Fibronectin expression is activated during EMT (epithelial-mesen...
- Enhancement of myosin II/actin turnover at the contractile ring induces slower furrowing in dividing HeLa cells
[作者:Kondo, T; Hamao, K; Kamijo, K; Kimura, H; Morita, M; Takahashi, M; Hosoya, H,期刊:Biochemical Journal, 页码:569-576 , 文章类型: Article,,卷期:2011年435-Part 3]
- Myosin II ATPase activity is enhanced by the phosphorylation of MRLC (myosin II regulatory light chain) in non-muscle cells. It is well known that pMRLC (phosphorylated MRLC) co-localizes with F-actin (filamentous actin)...
- Autotransporter passenger domain secretion requires a hydrophobic cavity at the extracellular entrance of the beta-domain pore
[作者:Zhai, YJ; Zhang, K; Huo, YW; Zhu, YS; Zhou, QJ; Lu, JW; Black, I; Pang, XY; Roszak, AW; Zhang, XJ; Isaacs, NW; Sun, F,期刊:Biochemical Journal, 页码:577-587 , 文章类型: Article,,卷期:2011年435-Part 3]
- Whooping cough (pertussis) is a highly contagious acute respiratory illness of humans caused by the Gram-negative bacterial pathogen Bordetella pertussis. The AT (autotransporter) BrkA (Bordetella serum-resistance killin...
- Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals
[作者:Morrone, D; Hillwig, ML; Mead, ME; Lowry, L; Fulton, DB; Peters, RJ,期刊:Biochemical Journal, 页码:589-595 , 文章类型: Article,,卷期:2011年435-Part 3]
- The evolution of natural product biosynthetic pathways can be envisioned to occur via a number of mechanisms. In the present study we provide evidence that latent plasticity plays a role in such metabolic evolution. In p...
- The C2 domain of Tollip, a Toll-like receptor signalling regulator, exhibits broad preference for phosphoinositides
[作者:Ankem, G; Mitra, S; Sun, FR; Moreno, AC; Chutvirasakul, B; Azurmendi, HF; Li, LW; Capelluto, DGS,期刊:Biochemical Journal, 页码:597-608 , 文章类型: Article,,卷期:2011年435-Part 3]
- TLRs (Toll-like receptors) provide a mechanism for host defence immune responses. Activated TLRs lead to the recruitment of adaptor proteins to their cytosolic tails, which in turn promote the activation of IRAKs (interl...
- Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas
[作者:Pellet-Many, C; Frankel, P; Evans, IM; Herzog, B; Junemann-Ramirez, M; Zachary, IC,期刊:Biochemical Journal, 页码:609-618 , 文章类型: Article,,卷期:2011年435-Part 3]
- NRP1 (neuropilin-1) is a co-receptor for members of the VEGF (vascular endothelial growth factor) family in endothelial cells, but is increasingly implicated in signalling induced by other growth factors. NRP1 is express...
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