- Hepatic Transport Mechanisms of Cholyl-L-Lysyl-Fluorescein
[作者:de Waart, DR; Hausler, S; Vlaming, MLH; Kunne, C; Hanggi, E; Gruss, HJ; Elferink, RPJO; Stieger, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:78-86 , 文章类型: Article,,卷期:2010年334-1]
- Cholyl-L-lysyl-fluorescein (CLF) is a fluorescent bile salt derivative that is being developed as an agent for determining in vivo liver function. However, the mechanisms of uptake and excretion by hepatocytes have not b...
- Generation of a Mouse Model with a Reversible Hypomorphic Cytochrome P450 Reductase Gene: Utility for Tissue-Specific Rescue of the Reductase Expression, and Insights from a Resultant Mouse Model with Global Suppression of P450 Reductase Expression in Extrahepatic Tissues
[作者:Wei, YA; Zhou, X; Fang, C; Li, L; Kluetzman, K; Yang, WZ; Zhang, QY; Ding, XX,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:69-77 , 文章类型: Article,,卷期:2010年334-1]
- A mouse model termed Cpr-low (CL) was recently generated, in which the expression of the cytochrome P450 reductase (Cpr) gene was globally down-regulated. The decreased CPR expression was accompanied by phenotypical chan...
- Lubiprostone Reverses the Inhibitory Action of Morphine on Intestinal Secretion in Guinea Pig and Mouse
[作者:Fei, GJ; Raehal, K; Liu, SM; Qu, MH; Sun, XH; Wang, GD; Wang, XY; Xia, Y; Schmid, CL; Bohn, LM; Wood, JD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:333-340 , 文章类型: Article,,卷期:2010年334-1]
- Lubiprostone activates CIC-2 chloride channels in epithelia. It is approved for treatment of chronic idiopathic constipation in adults and constipation-predominate irritable bowel syndrome in women. We tested a hypothesi...
- Bezafibrate Mildly Stimulates Ketogenesis and Fatty Acid Metabolism in Hypertriglyceridemic Subjects
[作者:Tremblay-Mercier, J; Tessier, D; Plourde, M; Fortier, M; Lorrain, D; Cunnane, SC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:341-346 , 文章类型: Article,,卷期:2010年334-1]
- Our objective was to determine whether bezafibrate, a hypotriglyceridemic drug and peroxisome proliferator-activated receptor (PPAR)-alpha agonist, is ketogenic and increases fatty acid oxidation in humans. We measured f...
- Effects of Propranolol on Bone Metabolism in Spontaneously Hypertensive Rats
[作者:Sato, T; Arai, M; Goto, S; Togari, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:99-105 , 文章类型: Article,,卷期:2010年334-1]
- The effects of propranolol (PRO), a nonselective beta-adrenergic receptor (beta-AR) antagonist with membrane-stabilizing action on bone metabolism, were examined in spontaneously hypertensive rats (SHR) showing osteoporo...
- Heme Arginate Therapy Enhanced Adiponectin and Atrial Natriuretic Peptide, but Abated Endothelin-1 with Attenuation of Kidney Histopathological Lesions in Mineralocorticoid-Induced Hypertension
[作者:Ndisang, JF; Jadhav, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:87-98 , 文章类型: Article,,卷期:2010年334-1]
- We investigated the role of heme oxygenase (HO), adiponectin, and atrial natriuretic peptide (ANP) in uninephrectomized (UnX) deoxycorticosterone-acetate (DOCA)-salt hypertensive rats, a volume-overload model characteriz...
- An Apolipoprotein E-Mimetic Stimulates Axonal Regeneration and Remyelination after Peripheral Nerve Injury
[作者:Li, FQ; Fowler, KA; Neil, JE; Colton, CA; Vitek, MP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:106-115 , 文章类型: Article,,卷期:2010年334-1]
- Elevated apolipoprotein E (apoE) synthesis within crushed sciatic nerves advocates that apoE could benefit axonal repair and reconstruction of axonal and myelin membranes. We created an apoE-mimetic peptide, COG112 (acet...
- Serotonin Receptors in Rat Jugular Vein: Presence and Involvement in the Contraction
[作者:Linder, AE; Gaskell, GL; Szasz, T; Thompson, JM; Watts, SW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:116-123 , 文章类型: Article,,卷期:2010年334-1]
- Serotonin (5-hydroxytryptamine; 5-HT) is released during platelet aggregation, a phenomenon commonly observed in blood clot formation and venous diseases. Once released, 5-HT can interact with its receptors in the periph...
- Role of alpha 5 Nicotinic Acetylcholine Receptors in Pharmacological and Behavioral Effects of Nicotine in Mice
[作者:Jackson, KJ; Marks, MJ; Vann, RE; Chen, X; Gamage, TF; Warner, JA; Damaj, MI,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:137-146 , 文章类型: Article,,卷期:2010年334-1]
- Incorporation of the alpha 5 nicotinic acetylcholine receptor ( nAChR) subunit can greatly influence nAChR function without altering receptor number. Although few animal studies have assessed the role of the alpha 5 nACh...
- Cholestyramine Reverses Hyperglycemia and Enhances Glucose-Stimulated Glucagon-Like Peptide 1 Release in Zucker Diabetic Fatty Rats
[作者:Chen, LH; McNulty, J; Anderson, D; Liu, YP; Nystrom, C; Bullard, S; Collins, J; Handlon, AL; Klein, R; Grimes, A; Murray, D; Brown, R; Krull, D; Benson, B; Kleymenova, E; Remlinger, K; Young, A; Yao, XZ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:164-170 , 文章类型: Article,,卷期:2010年334-1]
- Bile acid sequestrants (BAS) have shown antidiabetic effects in both humans and animals but the underlying mechanism is not clear. In the present study, we evaluated cholestyramine in Zucker diabetic fatty (ZDF) rats. Al...
- Pharmacological Profile of Lurasidone, a Novel Antipsychotic Agent with Potent 5-Hydroxytryptamine 7 (5-HT7) and 5-HT1A Receptor Activity
[作者:Ishibashi, T; Horisawa, T; Tokuda, K; Ishiyama, T; Ogasa, M; Tagashira, R; Matsumoto, K; Nishikawa, H; Ueda, Y; Toma, S; Oki, H; Tanno, N; Saji, I; Ito, A; Ohno, Y; Nakamura, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:171-181 , 文章类型: Article,,卷期:2010年334-1]
- Lurasidone [(3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl) piperazin-1-ylmethyl] cyclohexylmethyl}hexahydro-4,7-methano-2H-isoindole-1,3-dione hydrochloride; SM-13496] is an azapirone derivative and a novel an...
- Regulation of Inflammatory Pain by Inhibition of Fatty Acid Amide Hydrolase
[作者:Naidu, PS; Kinsey, SG; Guo, TL; Cravatt, BF; Lichtman, AH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:182-190 , 文章类型: Article,,卷期:2010年334-1]
- Although cannabinoids are efficacious in laboratory animal models of inflammatory pain, their established cannabimimetic actions diminish enthusiasm for their therapeutic development. Conversely, fatty acid amide hydrola...
|