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  • Conversion of amyloid positive and negative MCI to AD over 3 years An C-11-PIB PET study
    [作者:Okello, A; Koivunen, J; Edison, P; Archer, HA; Turkheimer, FE; Nagren, K; Bullock, R; Walker, Z; Kennedy, A; Fox, NC; Rossor, MN; Rinne, JO; Brooks, DJ,期刊:Neurology, 页码:754-760 , 文章类型: Article,,卷期:2009年73-10]
  • Background: Patients with amnestic mild cognitive impairment (MCI) represent an important clinical group as they are at increased risk of developing Alzheimer disease (AD). C-11-PIB PET is an in vivo marker of brain amyl...
  • Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease
    [作者:Pilotto, A; Franceschi, M; D'Onofrio, G; Bizzarro, A; Mangialasche, F; Cascavilla, L; Paris, F; Matera, MG; Pilotto, A; Daniele, A; Mecocci, P; Masullo, C; Dallapiccola, B; Seripa, D,期刊:Neurology, 页码:761-767 , 文章类型: Article,,卷期:2009年73-10]
  • Objective: To evaluate the influence of the single nucleotide polymorphism rs1080985 in the cytochrome P450 2D6 (CYP2D6) gene on the efficacy of donepezil in patients with mild to moderate Alzheimer disease (AD).Methods:...
  • Systemic inflammation and disease progression in Alzheimer disease
    [作者:Holmes, C; Cunningham, C; Zotova, E; Woolford, J; Dean, C; Kerr, S; Culliford, D; Perry, VH,期刊:Neurology, 页码:768-774 , 文章类型: Article,,卷期:2009年73-10]
  • Background: Acute and chronic systemic inflammation are characterized by the systemic production of the proinflammatory cytokine tumor necrosis factor alpha(TNF-alpha) that plays a role in immune to brain communication. ...
  • Using fast eye movements to study fatigue in multiple sclerosis
    [作者:Matta, M; Leigh, RJ; Pugliatti, M; Aiello, I; Serra, A,期刊:Neurology, 页码:798-804 , 文章类型: Article,,卷期:2009年73-10]
  • Objective: To investigate whether internuclear ophthalmoparesis (INO) due to demyelination of the medial longitudinal fasciculus (MLF) provides a model for studying the poorly understood symptom of fatigue in multiple sc...