- Boron nanoparticles inhibit turnour growth by boron neutron capture therapy in the murine B16-OVA model
[作者:Petersen, MS; Petersen, CC; Agger, R; Sutmuller, M; Jensen, MR; Sorensen, PG; Mortensen, MW; Hansen, T; Bjornholm, T; Gundersen, HJ; Huiskamp, R; Hokland, M,期刊:Anticancer Research, 页码:571-576 , 文章类型: Article,,卷期:2008年28-2A]
- Background: Boron neutron capture therapy usually relies on soluble, rather than particulate, boron compounds. This study evaluated the use of a novel boron nanoparticle for boron neutron capture therapy. Materials and M...
- A new micronized formulation of 2-methoxyestradiolbis-sulfamate (STX140) is therapeutically potent against breast cancer
[作者:Foster, PA; Newman, SP; Leese, MP; Bernetiere, S; Diolez, C; Camara, J; Hacher, B; Baronnet, MM; Ali, T; Potter, BVL; Reed, MJ; Purohit, A,期刊:Anticancer Research, 页码:577-581 , 文章类型: Article,,卷期:2008年28-2A]
- There is a continued need for orally bioavailable anticancer compounds that exhibit good efficacy against breast cancer. STX140, a derivative of 2-methoxyestradiol (2-MeOE2), has been shown to have excellent oral bioavai...
- Adenovirus-mediated inhibitor KB gene transfer improves the chemosensitivity to anticancer drugs in human lung cancer in vitro and in vivo
[作者:Ni, J; Takayama, K; Ushijima, R; Inoshima, N; Uchino, J; Harada, T; Minami, T; Takeshita, M; Zhou, C; Nakanishi, Y,期刊:Anticancer Research, 页码:601-608 , 文章类型: Article,,卷期:2008年28-2A]
- Background: Nuclear factor kappaB (NFKB) is a transcription cfa tor which is importantly implicated in cancer cell growth. In a previous report, we confirmed that lung cancer cell growth was suppressed significantly by t...
- Apoptosis induced by an alkylated purine, 6-dimethylaminopurine, and changes in gene expression in human lymphoma U937 cells
[作者:Nakashima, M; Cui, ZG; Tabuchi, Y; Takasaki, I; Zhao, QL; Kondo, T; Yu, DY; Shoji, M; Honda, T; Kitagawa, H; Kojima, Y; Nakano, T,期刊:Anticancer Research, 页码:609-620 , 文章类型: Article,,卷期:2008年28-2A]
- Apoptosis induced by an alkylated purine, 6-dimethylaminopurine (6-DMAP), was investigated to explore the p53-independent pathway in a human lymphoma U937 cell line. Here, it was discovered that the apoptosis was induced...
- Antisense-snail transfer inhibits tumor metastasis by inducing E-cadherin expression
[作者:Zhang, A; Chen, G; Meng, L; Wang, QS; Hu, W; Xi, L; Gao, QL; Wang, SX; Zhou, JF; Xu, G; Meng, L; Ma, D,期刊:Anticancer Research, 页码:621-628 , 文章类型: Article,,卷期:2008年28-2A]
- Carcinoma cell metastasis is mediated by increased mobility and invasiveness via epithelial-mesenchymal transition (EMT). Snail, a zinc-finger transcription factor, triggers EMT by directly repressing E-cadherin expressi...
- Combination therapy of S-1 with selective cyclooxygenase-2 inhibitor for liver metastasis of colorectal carcinoma
[作者:Tachimori, A; Yamada, N; Amano, R; Ohira, M; Hirakawa, K,期刊:Anticancer Research, 页码:629-638 , 文章类型: Article,,卷期:2008年28-2A]
- Background: Hepatic resection, the only curative treatment for liver metastasis of colorectal cancer has become standard treatment, but most cases of liver metastases are inoperable, and of the patients treated with hepa...
- DNA damage response in prostate cancer cells after high-intensity focused ultrasound (HIFU) treatment
[作者:Ide, H; Nakagawa, T; Terado, Y; Yasuda, M; Kamiyama, Y; Muto, S; Horie, S,期刊:Anticancer Research, 页码:639-643 , 文章类型: Article,,卷期:2008年28-2A]
- Background: High-intensity focused ultrasound (HIFU) is a new modality that can be used for local tumor ablation therapy. In the present study, the expression of human checkpoint kinase2 (Chk2), which may have significan...
- Identification of novel genes involved in the synergistic antitumor effect of caffeine in osteosarcoma cells using cDNA macroarray
[作者:Ii, S; Ueda, Y; Shimazaki, M; Katsuta, S; Takazawa, K; Kanazawa, Y; Tomita, K; Tsuchiya, H,期刊:Anticancer Research, 页码:645-653 , 文章类型: Article,,卷期:2008年28-2A]
- Background: Caffeine enhances the cytocidal effects of DNA-damaging agents. This study investigated genes involved in the synergistic effect of caffeine on osteosarcoma cells using gene-profiling analysis. Materials and ...
- Down-regulation of Plakoglobin in soft tissue sarcoma is associated with a higher risk of pulmonary metastasis
[作者:Kanazawa, Y; Ueda, Y; Shimasaki, M; Katsuda, S; Yamamoto, N; Tomita, K; Tsuchiya, H,期刊:Anticancer Research, 页码:655-664 , 文章类型: Article,,卷期:2008年28-2A]
- Soft tissue sarcomas (STS) behave with aggressiveness and metastatic potential, that can vary depending on their locations. There has been little information on the exact molecular mechanisms involved in their biological...
- Role of histone deacetylase inhibitor in adenovirus-mediated p53 gene therapy in esophageal cancer
[作者:Hoshino, I; Matsubara, H; Akutsu, Y; Nishimori, T; Yoneyama, Y; Murakami, K; Sakata, H; Matsushita, K; Komatsu, A; Brooks, R; Ochiai, T,期刊:Anticancer Research, 页码:665-671 , 文章类型: Article,,卷期:2008年28-2A]
- Background: Recently, the use of histone deacetylase inhibitors (HDACI) with gene therapy has been shown to improve the effect of this therapy. The effectiveness of one of the novel HDACIs, FK228, was examined in adenovi...
- Identification of potential chemoresistance genes in osteosarcoma
[作者:Walters, DK; Steinmann, P; Langsam, B; Schmutz, S; Born, W; Fuchs, B,期刊:Anticancer Research, 页码:673-679 , 文章类型: Article,,卷期:2008年28-2A]
- Background: Osteosarcoma (OS) is an aggressive bone malignancy that primarily affects children and adolescents. Patients with metastatic disease at diagnosis have only a 20% survival rate. The poor survival rate of these...
- Inhibition of PKCa activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412
[作者:Kawamoto, T; Akisue, T; Kishimoto, K; Hara, H; Imabori, M; Fujimoto, T; Kurosaka, M; Hitora, T; Kawaguchi, Y; Yamamoto, T,期刊:Anticancer Research, 页码:825-832 , 文章类型: Article,,卷期:2008年28-2A]
- Background: PKC412, formerly CGP41251, N-benzoylstaurosporine, was initially developed as a selective protein kinase C (PKC) inhibitor, and it preferentially inhibits conventional PKC family members. In this study, the e...
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