- (64)Cu-Labeled Lissamine Rhodamine B: A Promising PET Radiotracer Targeting Tumor Mitochondria
[作者:Zhou, Y; Kim, YS; Yan, X; Jacobson, O; Chen, XY; Liu, S,期刊:Molecular Pharmaceutics, 页码:1198-1208 , 文章类型: Article,,卷期:2011年8-4]
- Enhanced mitochondrial potential in carcinoma cells is an important characteristic of cancer. It is of great current interest to develop a radiotracer that is sensitive to mitochondrial potential changes at the early sta...
- Injectable PAMAM Dendrimer-PEG Hydrogels for the Treatment of Genital Infections: Formulation and in Vitro and in Vivo Evaluation
[作者:Navath, RS; Menjoge, AR; Dai, H; Romero, R; Kannan, S; Kannan, RM,期刊:Molecular Pharmaceutics, 页码:1209-1223 , 文章类型: Article,,卷期:2011年8-4]
- Local intravaginal drug therapy is preferred for treatment of ascending genital infections during pregnancy. In the present study, an in situ forming biodegradable hydrogel for sustained release of amoxicillin in the cer...
- Novel Tetrapeptide, RGDF, Mediated Tumor Specific Liposomal Doxorubicin (DOX) Preparations
[作者:Du, HR; Cui, CY; Wang, LL; Liu, H; Cui, GH,期刊:Molecular Pharmaceutics, 页码:1224-1232 , 文章类型: Article,,卷期:2011年8-4]
- Arginine-glycine-aspartate (RGD) has been shown to possess a strong affinity for the integrins overexpressed in tumor cells, especially during tumor invasion, angiogenesis and metasis. Based on work from others, a novel ...
- Polymer Swelling, Drug Mobilization and Drug Recrystallization in Hydrating Solid Dispersion Tablets Studied by Multinuclear NMR Microimaging and Spectroscopy
[作者:Dahlberg, C; Dvinskikh, SV; Schuleit, M; Furo, I,期刊:Molecular Pharmaceutics, 页码:1247-1256 , 文章类型: Article,,卷期:2011年8-4]
- Despite the advantages offered by solid dispersions, the marketed products based on this technology are few. The most frequent concern is the stability of the amorphous drug. The state of the drug in solid dispersions is...
- A 3-in-1 Polymeric Micelle Nanocontainer for Poorly Water-Soluble Drugs
[作者:Shin, HC; Alani, AWG; Cho, H; Bae, Y; Kolesar, JM; Kwon, GS,期刊:Molecular Pharmaceutics, 页码:1257-1265 , 文章类型: Article,,卷期:2011年8-4]
- Poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) micelles have a proven capacity for drug solubilization and have entered phase III clinical trials as a substitute for Cremophor EL in the delivery of paclita...
- Formation of Stable Hydrophilic C(60) Nanoparticles by 2-Hydroxypropyl-beta-cyclodextrin
[作者:Iohara, D; Hirayama, F; Higashi, K; Yamamoto, K; Uekama, K,期刊:Molecular Pharmaceutics, 页码:1276-1284 , 文章类型: Article,,卷期:2011年8-4]
- A number of papers have reported that the large cavity of gamma-CyD is favorable for inclusion of C(60) and forms a 1:2 (C(60):gamma-CyD) complex, whereas it is thought to be difficult for beta-CyD to form a complex at t...
- Synthesis and Characterization of a BODIPY Conjugate of the BCR-ABL Kinase Inhibitor Tasigna (Nilotinib): Evidence for Transport of Tasigna and Its Fluorescent Derivative by ABC Drug Transporters
[作者:Shukla, S; Skoumbourdis, AP; Walsh, MJ; Hartz, AMS; Fung, KL; Wu, CP; Gottesman, MM; Bauer, B; Thomas, CJ; Ambudkar, SV,期刊:Molecular Pharmaceutics, 页码:1292-1302 , 文章类型: Article,,卷期:2011年8-4]
- Tasigna (Nilotinib) is a BCR-ABL kinase inhibitor recently approved by the Food and Drug Administration, which is indicated for the treatment of drug-resistant chronic myelogenous leukemia (CML). The efflux of tyrosine k...
- pH-Sensitive Interaction of HMG-CoA Reductase Inhibitors (Statins) with Organic Anion Transporting Polypeptide 2B1
[作者:Varma, MV; Rotter, CJ; Chupka, J; Whalen, KM; Duignan, DB; Feng, B; Litchfield, J; Goosen, TC; El-Kattan, AF,期刊:Molecular Pharmaceutics, 页码:1303-1313 , 文章类型: Article,,卷期:2011年8-4]
- The human organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) is ubiquitously expressed and may play an important role in the disposition of xenobiotics. The present study aimed to examine the role of OATP2B1 i...
- Reversal of Lysosomal Storage in Brain of Adult MPS-I Mice with Intravenous Trojan Horse-Iduronidase Fusion Protein
[作者:Boado, RJ; Hui, EKW; Lu, JZ; Zhou, QH; Pardridge, WM,期刊:Molecular Pharmaceutics, 页码:1342-1350 , 文章类型: Article,,卷期:2011年8-4]
- A mouse model of mucopolysaccharidosis (MPS) type I, which is null for the lysosomal enzyme, alpha-L-iduronidase (IDUA), is treated with intravenous, receptor-mediated enzyme replacement therapy of the brain. Murine IDUA...
- Cytotoxicity Screening of Single-Walled Carbon Nanotubes: Detection and Removal of Cytotoxic Contaminants from Carboxylated Carbon Nanotubes
[作者:Wang, RH; Mikoryak, C; Li, SY; Bushdiecker, D; Musselman, IH; Pantano, P; Draper, RK,期刊:Molecular Pharmaceutics, 页码:1351-1361 , 文章类型: Article,,卷期:2011年8-4]
- This study compares the cytotoxicity to cultured mammalian cells of nine different single-walled carbon nanotube (SWNT) products synthesized by a variety of methods and obtained from a cross section of vendors. A standar...
- Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels
[作者:Shawahna, R; Uchida, Y; Decleves, X; Ohtsuki, S; Yousif, S; Dauchy, S; Jacob, A; Chassoux, F; Daumas-Duport, C; Couraud, PO; Terasaki, T; Scherrmann, JM,期刊:Molecular Pharmaceutics, 页码:1332-1341 , 文章类型: Article,,卷期:2011年8-4]
- We have investigated the transcriptomic and/or proteomic patterns of 71 solute carrier (SLC) and organic solute (OST) transporters, 34 ATP-binding cassette (ABC) transporters, and 51 metabolizing enzymes in human brain m...
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