- ATRX: Put Me on Repeat
[作者：Whitehouse, I; Owen-Hughes, T,期刊：Cell, 页码：335-336 , 文章类型： Editorial Material，,卷期：2010年143-3]
- Mutations in the chromatin-remodeling protein ATRX cause alpha thalassaemia and mental retardation, but the severity of the disorder is independent of the specific mutation. In this issue of Cell, Law et al. (2010) demon...
- Egg's ZP3 Structure Speaks Volumes
[作者：Wassarman, PM; Litscher, ES,期刊：Cell, 页码：337-338 , 文章类型： Editorial Material，,卷期：2010年143-3]
- Binding of mammalian sperm to eggs depends in part on ZP3, a glycoprotein in the egg's extracellular coat, the zona pellucida. In this issue, Han et al. (2010) describe the structure of an avian ZP3 homolog, providing in...
- Monocytes Join the Dendritic Cell Family
[作者：Sallusto, F; Lanzavecchia, A,期刊：Cell, 页码：339-340 , 文章类型： Editorial Material，,卷期：2010年143-3]
- Dendritic cells are professional antigen-presenting cells that mediate immunity and tolerance. Cheong et al. (2010) uncover a new route for dendritic cell production in vivo. They show that in response to infection by gr...
- Ephecting Excitatory Synapse Development
[作者：Dalva, MB,期刊：Cell, 页码：341-342 , 文章类型： Editorial Material，,卷期：2010年143-3]
- Alterations in synapse number and morphology are associated with devastating psychiatric and neurologic disorders. In this issue of Cell, Margolis et al. (2010) show that the RhoA-guanine exchange factor (GEF) Ephexin5 l...
- DNA Damage-Mediated Induction of a Chemoresistant Niche
[作者：Gilbert, LA; Hemann, MT,期刊：Cell, 页码：355-366 , 文章类型： Article，,卷期：2010年143-3]
- While numerous cell-intrinsic processes are known to play decisive roles in chemotherapeutic response, relatively little is known about the impact of the tumor microenvironment on therapeutic outcome. Here, we use a well...
- ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner
[作者：Law, MJ; Lower, KM; Voon, HPJ; Hughes, JR; Garrick, D; Viprakasit, V; Mitson, M; De Gobbi, M; Marra, M; Morris, A; Abbott, A; Wilder, SP; Taylor, S; Santos, GM; Cross, J; Ayyub, H; Jones, S; Ragoussis, J; Rhodes, D; Dunham, I; Higgs, DR; Gibbons, RJ,期刊：Cell, 页码：367-378 , 文章类型： Article，,卷期：2010年143-3]
- ATRX is an X-linked gene of the SWI/SNF family, mutations in which cause syndromal mental retardation and downregulation of a-globin expression. Here we show that ATRX binds to tandem repeat (TR) sequences in both telome...
- Upf1 Senses 3 ' UTR Length to Potentiate mRNA Decay
[作者：Hogg, JR; Goff, SP,期刊：Cell, 页码：379-389 , 文章类型： Article，,卷期：2010年143-3]
- The selective degradation of mRNAs by the nonsense-mediated decay pathway is a quality control process with important consequences for human disease. From initial studies using RNA hairpin-tagged mRNAs for purification o...
- The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation
[作者：Tian, D; Sun, S; Lee, JT,期刊：Cell, 页码：390-403 , 文章类型： Article，,卷期：2010年143-3]
- Once protein-coding, the X-inactivation center (Xic) is now dominated by large noncoding RNAs (ncRNA). X chromosome inactivation (XCI) equalizes gene expression between mammalian males and females by inactivating one X i...
- Insights into Egg Coat Assembly and Egg-Sperm Interaction from the X-Ray Structure of Full-Length ZP3
[作者：Han, L; Monne, M; Okumura, H; Schwend, T; Cherry, AL; Flot, D; Matsuda, T; Jovine, L,期刊：Cell, 页码：404-415 , 文章类型： Article，,卷期：2010年143-3]
- ZP3, a major component of the zona pellucida (ZP) matrix coating mammalian eggs, is essential for fertilization by acting as sperm receptor. By retaining a propeptide that contains a polymerization-blocking external hydr...
- Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209(+) Dendritic Cells for Immune T Cell Areas
[作者：Cheong, C; Matos, I; Choi, JH; Dandamudi, DB; Shrestha, E; Longhi, MP; Jeffrey, KL; Anthony, RM; Kluger, C; Nchinda, G; Koh, H; Rodriguez, A; Idoyaga, J; Pack, M; Velinzon, K; Park, CG; Steinman, RM,期刊：Cell, 页码：416-429 , 文章类型： Article，,卷期：2010年143-3]
- Dendritic cells (DCs), critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes. It is not yet established if the large reservoir of monocytes can develop ...
- Endophilin Functions as a Membrane-Bending Molecule and Is Delivered to Endocytic Zones by Exocytosis
[作者：Bai, JH; Hu, ZT; Dittman, JS; Pym, ECG; Kaplan, JM,期刊：Cell, 页码：430-441 , 文章类型： Article，,卷期：2010年143-3]
- Two models have been proposed for endophilin function in synaptic vesicle (SV) endocytosis. The scaffolding model proposes that endophilin's SH3 domain recruits essential endocytic proteins, whereas the membrane-bending ...
- EphB-Mediated Degradation of the RhoA GEF Ephexin5 Relieves a Developmental Brake on Excitatory Synapse Formation
[作者：Margolis, SS; Salogiannis, J; Lipton, DM; Mandel-Brehm, C; Wills, ZP; Mardinly, AR; Hu, LD; Greer, PL; Bikoff, JB; Ho, HYH; Soskis, MJ; Sahin, M; Greenberg, ME,期刊：Cell, 页码：442-455 , 文章类型： Article，,卷期：2010年143-3]
- The mechanisms that promote excitatory synapse formation and maturation have been extensively studied. However, the molecular events that limit excitatory synapse development so that synapses form at the right time and p...
- Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation
[作者：Bartke, T; Vermeulen, M; Xhemalce, B; Robson, SC; Mann, M; Kouzarides, T,期刊：Cell, 页码：470-484 , 文章类型： Article，,卷期：2010年143-3]
- Modifications on histones or on DNA recruit proteins that regulate chromatin function. Here, we use nucleosomes methylated on DNA and on histone H3 in an affinity assay, in conjunction with a SILAC-based proteomic analys...
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