- Discovery of a Proneurogenic, Neuroprotective Chemical
[作者：Pieper, AA; Xie, SH; Capota, E; Estill, SJ; Zhong, JN; Long, JM; Becker, GL; Huntington, P; Goldman, SE; Shen, CH; Capota, M; Britt, JK; Kotti, T; Ure, K; Brat, DJ; Williams, NS; MacMillan, KS; Naidoo, J; Melito, L; Hsieh, J; De Brabander, J; Ready, JM; McKnight, SL,期刊：Cell, 页码：39-51 , 文章类型： Article，,卷期：2010年142-1]
- An in vivo screen was performed in search of chemicals capable of enhancing neuron formation in the hippocampus of adult mice. Eight of 1000 small molecules tested enhanced neuron formation in the subgranular zone of the...
- Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis Causes Cancer Remission and Inhibition
[作者：Cao, L; Liu, XL; Lin, EJD; Wang, CS; Choi, EY; Riban, V; Lin, B; During, MJ,期刊：Cell, 页码：52-64 , 文章类型： Article，,卷期：2010年142-1]
- Cancer is influenced by its microenvironment, yet broader, environmental effects also play a role but remain poorly defined. We report here that mice living in an enriched housing environment show reduced tumor growth an...
- Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2
[作者：MacKay, C; Declais, AC; Lundin, C; Agostinho, A; Deans, AJ; MacArtney, TJ; Hofmann, K; Gartner, A; West, SC; Helleday, T; Lilley, DMJ; Rouse, J,期刊：Cell, 页码：65-76 , 文章类型： Article，,卷期：2010年142-1]
- DNA interstrand crosslinks (ICLs) are highly toxic because they block the progression of replisomes. The Fanconi Anemia (FA) proteins, encoded by genes that are mutated in FA, are important for repair of ICLs. The FA cor...
- Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents
[作者：Kratz, K; Schopf, B; Kaden, S; Sendoel, A; Eberhard, R; Lademann, C; Cannavo, E; Sartori, AA; Hengartner, MO; Jiricny, J,期刊：Cell, 页码：77-88 , 文章类型： Article，,卷期：2010年142-1]
- Cytotoxicity of cisplatin and mitomycin C (MMC) is ascribed largely to their ability to generate interstrand crosslinks (ICLs) in DNA, which block the progression of replication forks. The processing of ICLs requires the...
- Allostery and Intrinsic Disorder Mediate Transcription Regulation by Conditional Cooperativity
[作者：Garcia-Pino, A; Balasubramanian, S; Wyns, L; Gazit, E; De Greve, H; Magnuson, RD; Charlier, D; van Nuland, NAJ; Loris, R,期刊：Cell, 页码：101-111 , 文章类型： Article，,卷期：2010年142-1]
- Regulation of the phd/doc toxin-antitoxin operon involves the toxin Doc as co- or derepressor depending on the ratio between Phd and Doc, a phenomenon known as conditional cooperativity. The mechanism underlying this obs...
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