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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   Untitled [作者：Caldwell, GW,期刊：Current Topics in Medicinal Chemistry, 页码：1223-1223 , 文章类型： Editorial Material，,卷期：2012年12-11] Recent Advances in Positron Emission Tomography (PET) Radiotracers for Imaging Phosphodiesterases [作者：Andres, JI; De Angelis, M; Alcazar, J; Celen, S; Bormans, G,期刊：Current Topics in Medicinal Chemistry, 页码：1224-1236 , 文章类型： Review，,卷期：2012年12-11] Phosphodiesterases (PDEs) are a family of enzymes that metabolically inactivate the second messengers 3',5'-cyclic adenosine monophosphate (cAMP) and/or 3', 5'-cyclic guanosine monophosphate (cGMP). These two messengers ... An Integrated Data Management Framework for Drug Discovery - From Data Capturing to Decision Support [作者：Cedeno, W; Alex, S; Jaeger, EP; Agrafiotis, DK; Lobanov, VS,期刊：Current Topics in Medicinal Chemistry, 页码：1237-1242 , 文章类型： Review，,卷期：2012年12-11] Drug discovery is a highly complex process requiring scientists from wide-ranging disciplines to work together in a well-coordinated and streamlined fashion. While the process can be compartmentalized into well-defined f... A Novel Method for Determination of Drug Distribution in Rat Brain Tissue Sections by LC/MS/MS: Functional Tissue Microanalysis [作者：Masucci, JA; Mahan, AD; Kwasnoski, JD; Caldwell, GW,期刊：Current Topics in Medicinal Chemistry, 页码：1243-1249 , 文章类型： Review，,卷期：2012年12-11] Determination of drug distribution in brain and other tissues is important in pharmaceutical research. Tissue drug levels need to be determined routinely as they are usually diagnostic for both efficacy and toxicity. Det... Screening Strategy for Chiral and Achiral Separations in Supercritical Fluid Chromatography Mode [作者：Speybrouck, D; Corens, D; Argoullon, JM,期刊：Current Topics in Medicinal Chemistry, 页码：1250-1263 , 文章类型： Review，,卷期：2012年12-11] Supercritical fluid (SF) was discovered 200 years ago, but the use of this fluid as a mobile phase in chromatography only became popular fifty years ago. The development of the supercritical fluid chromatography (SFC) wa... Chromatographic Separation of Bioactive Oxycholesterols by GC, HPLC and SFC [作者：McAllister, H; Wu, JJ,期刊：Current Topics in Medicinal Chemistry, 页码：1264-1270 , 文章类型： Review，,卷期：2012年12-11] In this paper we report the development of chromatographic methods for the separation of 8 biologically active hydroxycholesterols (OHC's) which include the single-hydroxyl addition species 7 alpha-OHC, 7 beta-OHC, 25-OH... Insights from Structural Analysis of cFMS/Inhibitor Complexes: Common Interactions Via Three Structurally Dissimilar Scaffolds [作者：DesJarlais, RL,期刊：Current Topics in Medicinal Chemistry, 页码：1271-1281 , 文章类型： Review，,卷期：2012年12-11] A small-molecule drug discovery effort can benefit from having several chemical series. Where multiple series are not available, it is often the goal of a project to find novel scaffolds. Structural studies of ligand/pro... The IC50 Concept Revisited [作者：Caldwell, GW; Yan, ZY; Lang, WS; Masucci, JA,期刊：Current Topics in Medicinal Chemistry, 页码：1282-1290 , 文章类型： Review，,卷期：2012年12-11] A major strategy used in drug design is the inhibition of enzyme activity. The ability to accurately measure the concentration of the inhibitor which is required to inhibit a given biological or biochemical function by h... The Current Status of Time Dependent CYP Inhibition Assay and In Silico Drug-drug Interaction Predictions [作者：Yan, ZY; Caldwell, GW,期刊：Current Topics in Medicinal Chemistry, 页码：1291-1297 , 文章类型： Review，,卷期：2012年12-11] Various CYP time-dependent inhibition (TDI) assays have been widely implemented in drug discovery and development which has led to great success in positively identifying compounds with mechanism-base inhibition liabilit... Small Molecule Compound Logistics Outsourcing - Going Beyond the "Thought Experiment" [作者：Ramsay, DL; Kwasnoski, JD; Caldwell, GW,期刊：Current Topics in Medicinal Chemistry, 页码：1298-1308 , 文章类型： Review，,卷期：2012年12-11] Increasing pressure on the pharmaceutical industry to reduce cost and focus internal resources on "high value" activities is driving a trend to outsource traditionally "in-house" drug discovery activities. Compound colle...