New apoptosis modulating agents are widely sought, because failure in regulation of apoptosis is associated with many diseases. In this study, we have evaluated apoptosis inducing the potential of ten new hydrophobic ...

Ruscogenin (RUS), first isolated from Ruscus aculeatus, is also a major steroidal sapogenin of the traditional Chinese herb Radix Ophiopogon japonicus. It has robust anti-inflammatory activities. In previous studies, ...

The estrogen-related receptor alpha (ERR alpha) was one of the first orphan receptors identified through a search for genes encoding proteins related to the steroid nuclear receptor, Estrogen Receptor alpha (ER alpha)...

Bone marrow stromal cells (BMSCs) play a central role in human multiple myeloma(MM) cell survival and proliferation. We explored the possibility of using BMSCs as a target for MM treatment using genistein, a chemoprev...

A new series of 3-(4-chloro phenyl)-2-substituted-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-(4-chloro phenyl)-3H-quinazolin-4-one with different aldehydes and ketones. The comp...

Alzheimer's disease (AD) is a major neurodegenerative disorder in the elderly and is the most common form of dementia. Approved AD drugs like donepezil and memantine provide some cognitive benefits to a subset of pati...