- 1,25-Dihydroxyvitamin D-3 suppresses inflammation-induced expression of plasminogen activator inhibitor-1 by blocking nuclear factor-kappa B activation
[作者:Chen, YZ; Kong, JA; Sun, T; Li, G; Szeto, FL; Liu, WC; Deb, DK; Wang, YL; Zhao, Q; Thadhani, R; Li, YC,期刊:Archives of Biochemistry and Biophysics , 页码:241-247 , 文章类型: Article,,卷期:2011年507-2]
- Plasminogen activator inhibitor (PAI)-1 is a major fibrinolytic inhibitor. High PAI-1 is associated with increased renal and cardiovascular disease risk. Previous studies demonstrated PAI-1 down-regulation by 1,25-dihydr...
- Protein phosphatases: Possible bisphosphonate binding sites mediating stimulation of osteoblast proliferation
[作者:Morelli, S; Bilbao, PS; Katz, S; Lezcano, V; Roldan, E; Boland, R; Santillan, G,期刊:Archives of Biochemistry and Biophysics , 页码:248-253 , 文章类型: Article,,卷期:2011年507-2]
- We investigated the existence of a bisphosphonate (BP) target site in osteoblasts. Binding assays using [H-3]-olpadronate ([H-3]OPD) in whole cells showed the presence of specific, saturable and high affinity binding for...
- Genetic variations within the ERE motif modulate plasticity and energetics of binding of DNA to the ER alpha nuclear receptor
[作者:Deegan, BJ; Bhat, V; Seldeen, KL; McDonald, CB; Farooq, A,期刊:Archives of Biochemistry and Biophysics , 页码:262-270 , 文章类型: Article,,卷期:2011年507-2]
- Upon binding to estrogens, the ER alpha nuclear receptor acts as a transcription factor and mediates a multitude of cellular functions central to health and disease. Herein, using isothermal titration calorimetry (ITC) a...
- Tryparedoxin peroxidases from Trypanosoma cruzi: High efficiency in the catalytic elimination of hydrogen peroxide and peroxynitrite
[作者:Pineyro, MD; Arcari, T; Robello, C; Radi, R; Trujillo, M,期刊:Archives of Biochemistry and Biophysics , 页码:287-295 , 文章类型: Article,,卷期:2011年507-2]
- During host cell infection, Trypanosoma cruzi parasites are exposed to reactive oxygen and nitrogen species. As part of their antioxidant defense systems, they express two tryparedoxin peroxidases (TXNPx), thiol-dependen...
- TOX4 and its binding partners recognize DNA adducts generated by platinum anticancer drugs
[作者:du Puch, CBM; Barbier, E; Kraut, A; Coute, Y; Fuchs, J; Buhot, A; Livache, T; Seve, M; Favier, A; Douki, T; Gasparutto, D; Sauvaigo, S; Breton, J,期刊:Archives of Biochemistry and Biophysics , 页码:296-303 , 文章类型: Article,,卷期:2011年507-2]
- Platinating agents are commonly prescribed anticancer drugs damaging DNA. Induced lesions are recognized by a wide range of proteins. These are involved in cellular mechanisms such as DNA repair, mediation of cytotoxicit...
- Exploring the molecular basis of human manganese superoxide dismutase inactivation mediated by tyrosine 34 nitration
[作者:Moreno, DM; Marti, MA; De Biase, PM; Estrin, DA; Demicheli, V; Radi, R; Boechi, L,期刊:Archives of Biochemistry and Biophysics , 页码:304-309 , 文章类型: Article,,卷期:2011年507-2]
- Manganese Superoxide Dismutase (MnSOD) is an essential mitochondrial antioxidant enzyme that protects organisms against oxidative damage, dismutating superoxide radical (O-2(center dot-)) into H2O2 and O-2. The active si...
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