- Saposins utilize two strategies for lipid transfer and CD1 antigen presentation
[作者:Leon, L; Tatituri, RVV; Grenha, R; Sun, Y; Barral, DC; Minnaard, AJ; Bhowruth, V; Veerapen, N; Besra, GS; Kasmar, A; Peng, W; Moody, DB; Grabowski, GA; Brenner, MB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4357-4364 , 文章类型: Article,,卷期:2012年109-12]
- Transferring lipid antigens from membranes into CD1 antigen-presenting proteins represents a major molecular hurdle necessary for T-cell recognition. Saposins facilitate this process, but the mechanisms used are not well...
- Scanning probe-enabled nanocombinatorics define the relationship between fibronectin feature size and stem cell fate
[作者:Giam, LR; Massich, MD; Hao, LL; Wong, LS; Mader, CC; Mirkin, CA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4377-4382 , 文章类型: Article,,卷期:2012年109-12]
- We report the development of a powerful analytical method that utilizes a tilted elastomeric pyramidal pen array in the context of a scanning probe lithography experiment to rapidly prepare libraries having as many as 25...
- Rapid self-healing hydrogels
[作者:Phadke, A; Zhang, C; Arman, B; Hsu, CC; Mashelkar, RA; Lele, AK; Tauber, MJ; Arya, G; Varghese, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4383-4388 , 文章类型: Article,,卷期:2012年109-12]
- Synthetic materials that are capable of autonomous healing upon damage are being developed at a rapid pace because of their many potential applications. Despite these advancements, achieving self-healing in permanently c...
- Lateral prefrontal cortex contributes to maladaptive decisions
[作者:Xue, G; Juan, CH; Chang, CF; Lu, ZL; Dong, Q,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4401-4406 , 文章类型: Article,,卷期:2012年109-12]
- Humans consistently make suboptimal decisions involving random events, yet the underlying neural mechanisms remain elusive. Using functional MRI and a matching pennies game that captured subjects' increasing tendency to ...
- Population bulk segregant mapping uncovers resistance mutations and the mode of action of a chitin synthesis inhibitor in arthropods
[作者:Van Leeuwen, T; Demaeght, P; Osborne, EJ; Dermauw, W; Gohlke, S; Nauen, R; Grbic, M; Tirry, L; Merzendorfer, H; Clark, RM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4407-4412 , 文章类型: Article,,卷期:2012年109-12]
- Because of its importance to the arthropod exoskeleton, chitin biogenesis is an attractive target for pest control. This point is demonstrated by the economically important benzoylurea compounds that are in wide use as h...
- Transferred melanoma-specific CD8(+) T cells persist, mediate tumor regression, and acquire central memory phenotype
[作者:Chapuis, AG; Thompson, JA; Margolin, KA; Rodmyre, R; Lai, IP; Dowdy, K; Farrar, EA; Bhatia, S; Sabath, DE; Cao, JH; Li, YQ; Yee, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4592-4597 , 文章类型: Article,,卷期:2012年109-12]
- Adoptively transferred tumor-specific T cells offer the potential for non-cross-resistant therapy and long-term immunoprotection. Strategies to enhance in vivo persistence of transferred T cells can lead to improved anti...
- Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation
[作者:O'Boyle, G; Fox, CRJ; Walden, HR; Willet, JDP; Mavin, ER; Hine, DW; Palmer, JM; Barker, CE; Lamb, CA; Ali, S; Kirby, JA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4598-4603 , 文章类型: Article,,卷期:2012年109-12]
- The recruitment of T lymphocytes during diseases such as rheumatoid arthritis is regulated by stimulation of the chemokine receptors expressed by these cells. This study was designed to assess the potential of a CXCR3-sp...
- Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery
[作者:Li, HR; Zhou, HY; Wang, D; Qiu, JS; Zhou, Y; Li, XQ; Rosenfeld, MG; Ding, S; Fu, XD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4609-4614 , 文章类型: Article,,卷期:2012年109-12]
- The advent of powerful genomics technologies has uncovered many fundamental aspects of biology, including the mechanisms of cancer; however, it has not been appropriately matched by the development of global approaches t...
- F1Fo-ATPase, F-type proton-translocating ATPase, at the plasma membrane is critical for efficient influenza virus budding
[作者:Gorai, T; Goto, H; Noda, T; Watanabe, T; Kozuka-Hata, H; Oyama, M; Takano, R; Neumann, G; Watanabe, S; Kawaoka, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4615-4620 , 文章类型: Article,,卷期:2012年109-12]
- The identification of host factors involved in virus replication is important to understand virus life cycles better. Accordingly, we sought host factors that interact with the influenza viral nonstructural protein 2 by ...
- Dysmyelination not demyelination causes neurological symptoms in preweaned mice in a murine model of Cockayne syndrome
[作者:Revet, I; Feeney, L; Tang, AA; Huang, EJ; Cleaver, JE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4627-4632 , 文章类型: Article,,卷期:2012年109-12]
- Cockayne syndrome (CS) is a rare autosomal recessive neurodegenerative disease that is associated with mutations in either of two transcription-coupled DNA repair genes, CSA or CSB. Mice with a targeted mutation in the C...
|