- The conserved metalloprotease invadolysin localizes to the surface of lipid droplets
[作者:Cobbe, N; Marshall, KM; Rao, SG; Chang, CW; Di Cara, F; Duca, E; Vass, S; Kassan, A; Heck, MMS,期刊:Journal of cell science, 页码:3414-3423 , 文章类型: Article,,卷期:2009年122-18]
- Invadolysin is a metalloprotease conserved in many different organisms, previously shown to be essential in Drosophila with roles in cell division and cell migration. The gene seems to be ubiquitously expressed and four ...
- Animal cell hydraulics
[作者:Charras, GT; Mitchison, TJ; Mahadevan, L,期刊:Journal of cell science, 页码:3233-3241 , 文章类型: Article,,卷期:2009年122-18]
- Water is the dominant ingredient of cells and its dynamics are crucial to life. We and others have suggested a physical picture of the cell as a soft, fluid-infiltrated sponge, surrounded by a water-permeable barrier. To...
- Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions
[作者:Ogawa, H; Ohta, N; Moon, W; Matsuzaki, F,期刊:Journal of cell science, 页码:3242-3249 , 文章类型: Article,,卷期:2009年122-18]
- Drosophila neural stem cells or neuroblasts undergo typical asymmetric cell division. An evolutionally conserved protein complex, comprising atypical protein kinase C (aPKC), Bazooka (Par-3) and Par-6, organizes cell pol...
- Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity
[作者:Raspe, M; Gillis, J; Krol, H; Krom, S; Bosch, K; van Veen, H; Reits, E,期刊:Journal of cell science, 页码:3262-3271 , 文章类型: Article,,卷期:2009年122-18]
- Several neurodegenerative disorders, including Huntington's disease, are caused by expansion of the polyglutamine (polyQ) tract over 40 glutamines in the disease-related protein. Fragments of these proteins containing th...
- Nap1-mediated actin remodeling is essential for mammalian myoblast fusion
[作者:Nowak, SJ; Nahirney, PC; Hadjantonakis, AK; Baylies, MK,期刊:Journal of cell science, 页码:3282-3293 , 文章类型: Article,,卷期:2009年122-18]
- Myoblast fusion is crucial for the formation, growth, maintenance and regeneration of healthy skeletal muscle. Unfortunately, the molecular machinery, cell behaviors, and membrane and cytoskeletal remodeling events that ...
- VEGF and inhibitors of TGF beta type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha 5-integrin expression
[作者:Liu, Z; Kobayashi, K; van Dinther, M; van Heiningen, SH; Valdimarsdottir, G; van Laar, T; Scharpfenecker, M; Lowik, CWGM; Goumans, MJ; ten Dijke, P; Pardali, E,期刊:Journal of cell science, 页码:3294-3302 , 文章类型: Article,,卷期:2009年122-18]
- Vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF beta) are potent regulators of angiogenesis. How VEGF and TGF beta signaling pathways crosstalk is not well understood. Therefore, we ana...
- VEGFR2-PLC gamma 1 axis is essential for endothelial specification of VEGFR2(+) vascular progenitor cells
[作者:Sase, H; Watabe, T; Kawasaki, K; Miyazono, K; Miyazawa, K,期刊:Journal of cell science, 页码:3303-3311 , 文章类型: Article,,卷期:2009年122-18]
- Vascular endothelial growth factor receptor 2 (VEGFR2) plays crucial roles in vasculogenesis, a process involving cell proliferation, migration and differentiation. However, the molecular mechanism by which VEGFR2 signal...
- An intrinsic quality-control mechanism ensures unconventional secretion of fibroblast growth factor 2 in a folded conformation
[作者:Torrado, LC; Temmerman, K; Muller, HM; Mayer, MP; Seelenmeyer, C; Backhaus, R; Nickel, W,期刊:Journal of cell science, 页码:3322-3329 , 文章类型: Article,,卷期:2009年122-18]
- Fibroblast growth factor 2 (FGF2) is a proangiogenic mitogen that is secreted by an unconventional mechanism, which does not depend on a functional ER-Golgi system. FGF2 is first recruited to the inner leaflet of plasma ...
- Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux
[作者:Rossi, M; Munarriz, ER; Bartesaghi, S; Milanese, M; Dinsdale, D; Guerra-Martin, MA; Bampton, ETW; Glynn, P; Bonanno, G; Knight, RA; Nicotera, P; Melino, G,期刊:Journal of cell science, 页码:3330-3339 , 文章类型: Article,,卷期:2009年122-18]
- Alterations in the autophagic pathway are associated with the onset and progression of various diseases. However, despite the therapeutic potential for pharmacological modulators of autophagic flux, few such compounds ha...
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