- The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth
[作者:Hamaratoglu, F; Gajewski, K; Sansores-Garcia, L; Morrison, C; Tao, CY; Halder, G,期刊:Journal of cell science, 页码:2351-2359 , 文章类型: Article,,卷期:2009年122-14]
- The Hippo tumor-suppressor pathway controls tissue growth in Drosophila and mammals by regulating cell proliferation and apoptosis. The Hippo pathway includes the Fat cadherin, a transmembrane protein, which acts upstrea...
- The Hippo pathway regulates apical-domain size independently of its growth-control function
[作者:Genevet, A; Polesello, C; Blight, K; Robertson, F; Collinson, LM; Pichaud, F; Tapon, N,期刊:Journal of cell science, 页码:2360-2370 , 文章类型: Article,,卷期:2009年122-14]
- The Hippo pathway, identified in Drosophila and conserved in vertebrates, regulates tissue growth by promoting cell cycle exit and apoptosis. In addition to their well-characterised overproliferation phenotype, adult Dro...
- Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5
[作者:Seaman, MNJ; Harbour, ME; Tattersall, D; Read, E; Bright, N,期刊:Journal of cell science, 页码:2371-2382 , 文章类型: Article,,卷期:2009年122-14]
- Retromer is a membrane-associated heteropentameric coat complex that functions in the endosome-to-Golgi retrieval of the cation-independent mannose-6-phosphate receptor, the Wntless protein and other membrane proteins of...
- Cul4 and DDB1 regulate Orc2 localization, BrdU incorporation and Dup stability during gene amplification in Drosophila follicle cells
[作者:Lin, HC; Wu, JT; Tan, BCM; Chien, CT,期刊:Journal of cell science, 页码:2393-2401 , 文章类型: Article,,卷期:2009年122-14]
- In higher eukaryotes, the pre-replication complex (pre-RC) component Cdt1 is the major regulator in licensing control for DNA replication. The Cul4-DDB1-based ubiquitin ligase mediates Cdt1 ubiquitylation for subsequent ...
- The a2 mating-type-locus gene lga2 of Ustilago maydis interferes with mitochondrial dynamics and fusion, partially in dependence on a Dnm1-like fission component
[作者:Mahlert, M; Vogler, C; Stelter, K; Hause, G; Basse, CW,期刊:Journal of cell science, 页码:2402-2412 , 文章类型: Article,,卷期:2009年122-14]
- The a2 mating-type-locus gene lga2 of the basidiomycete Ustilago maydis encodes a mitochondrial protein that interferes with mitochondrial morphology and integrity, and that plays a role in uniparental inheritance of mit...
- Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants
[作者:Vaccari, T; Rusten, TE; Menut, L; Nezis, IP; Brech, A; Stenmark, H; Bilder, D,期刊:Journal of cell science, 页码:2413-2423 , 文章类型: Article,,卷期:2009年122-14]
- ESCRT proteins were initially isolated in yeast as a single functional set of conserved components controlling endosomal cargo sorting and multivesicular body (MVB) biogenesis. Recent work has suggested that metazoan ESC...
- Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons
[作者:Scales, TME; Lin, S; Kraus, M; Goold, RG; Gordon-Weeks, PR,期刊:Journal of cell science, 页码:2424-2435 , 文章类型: Article,,卷期:2009年122-14]
- MAP1B is a developmentally regulated microtubule-associated phosphoprotein that regulates microtubule dynamics in growing axons and growth cones. We used mass spectrometry to map 28 phosphorylation sites on MAP1B, and se...
- RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment
[作者:Raaijmakers, JA; Tanenbaum, ME; Maia, AF; Medema, RH,期刊:Journal of cell science, 页码:2436-2445 , 文章类型: Article,,卷期:2009年122-14]
- During mitosis, kinetochores need to attach to microtubules emanating from spindle poles. Several protein complexes have been shown to mediate the kinetochore-microtubule interaction. However, with the continually growin...
- BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes
[作者:Kouznetsova, A; Wang, H; Bellani, M; Camerini-Otero, RD; Jessberger, R; Hoog, C,期刊:Journal of cell science, 页码:2446-2452 , 文章类型: Article,,卷期:2009年122-14]
- Transcriptional silencing of the sex chromosomes during male meiosis is regarded as a manifestation of a general mechanism active in both male and female germ cells, called meiotic silencing of unsynapsed chromatin (MSUC...
- The yeast endocytic protein Epsin 2 functions in a cell-division signaling pathway
[作者:Mukherjee, D; Coon, BG; Edwards, DF; Hanna, CB; Longhi, SA; McCaffery, JM; Wendland, B; Retegui, LA; Bi, E; Aguilar, RC,期刊:Journal of cell science, 页码:2453-2463 , 文章类型: Article,,卷期:2009年122-14]
- The epsins are a family of adaptors involved in recruiting other endocytic proteins, binding of ubiquitylated cargo and induction of membrane curvature. These molecules bear a characteristic epsin N-terminal homology (EN...
- Nuclear shape, growth and integrity in the closed mitosis of fission yeast depend on the Ran-GTPase system, the spindle pole body and the endoplasmic reticulum
[作者:Gonzalez, Y; Meerbrey, K; Chong, J; Torii, Y; Padte, NN; Sazer, S,期刊:Journal of cell science, 页码:2464-2472 , 文章类型: Article,,卷期:2009年122-14]
- The double lipid bilayer of the nuclear envelope (NE) remains intact during closed mitosis. In the fission yeast Schizosaccharomyces pombe, the intranuclear mitotic spindle has envelope-embedded spindle pole bodies (SPB)...
- Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition
[作者:Yang, XF; Pursell, B; Lu, SL; Chang, TK; Mercurio, AM,期刊:Journal of cell science, 页码:2473-2480 , 文章类型: Article,,卷期:2009年122-14]
- The beta 4 integrin is expressed in epithelial cells, a few other cell types and in some carcinomas. Despite this restricted expression pattern and the functional importance of beta 4 integrin in epithelial and carcinoma...
- Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones
[作者:Mashukova, A; Oriolo, AS; Wald, FA; Casanova, ML; Kroger, C; Magin, TM; Omary, MB; Salas, PJI,期刊:Journal of cell science, 页码:2491-2503 , 文章类型: Article,,卷期:2009年122-14]
- Atypical PKC (PKC iota) is a key organizer of cellular asymmetry. Sequential extractions of intestinal cells showed a pool of enzymatically active PKC iota and the chaperone Hsp70.1 attached to the apical cytoskeleton. P...
- Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification
[作者:Sun-Wada, GH; Tabata, H; Kawamura, N; Aoyama, M; Wada, Y,期刊:Journal of cell science, 页码:2504-2513 , 文章类型: Article,,卷期:2009年122-14]
- The nascent phagosome progressively establishes an acidic milieu by acquiring a proton pump, the vacuolar-type ATPase (V-ATPase). However, the origin of phagosomal V-ATPase remains poorly understood. We found that phagos...
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