- Effect of a caspase inhibitor, zVADfmk, on the inhibition of breast cancer cells by herpes simplex virus type 1
[作者:Wood, LW; Shillitoe, EJ,期刊:Cancer gene therapy, 页码:685-694 , 文章类型: Article,,卷期:2011年18-10]
- The oncolytic effects of herpes simplex virus-1 (HSV-1) are limited, possibly because of premature death of infected cells by apoptosis, which limits the amount of progeny virus that is produced. It has been proposed tha...
- Comparison of distribution and activity of nanoparticles with short interfering DNA (Dbait) in various living systems
[作者:Berthault, N; Maury, B; Agrario, C; Herbette, A; Sun, JS; Peyrieras, N; Dutreix, M,期刊:Cancer gene therapy, 页码:695-706 , 文章类型: Article,,卷期:2011年18-10]
- Introducing small DNA molecules (Dbait) impairs the repair of damaged chromosomes and provides a new method for enhancing the efficiency of radiotherapy in radio-resistant tumors. The radiosensitizing activity is depende...
- Selective modification of HK peptides enhances siRNA silencing of tumor targets in vivo
[作者:Chou, ST; Leng, Q; Scaria, P; Woodle, M; Mixson, AJ,期刊:Cancer gene therapy, 页码:707-716 , 文章类型: Article,,卷期:2011年18-10]
- Our research has focused on systemic delivery of small interference RNA (siRNA) by branched peptides composed of histidine and lysine. After studying several histidine-lysine (HK) peptides, one four-branched peptide, H3K...
- Assessment of an altered E1B promoter on the specificity and potency of triple-regulated conditionally replicating adenoviruses: implications for the generation of ideal m-CRAs
[作者:Horikawa, Y; Wang, Y; Nagano, S; Kamizono, J; Ikeda, M; Komiya, S; Kosai, K,期刊:Cancer gene therapy, 页码:724-733 , 文章类型: Article,,卷期:2011年18-10]
- Although previous studies modified two components of conditionally replicating adenoviruses (CRAs), which selectively replicate in and kill cancer cells, the most accurate ways to achieve increased cancer specificity (th...
- Mining the adenovirus virome for oncolytics against multiple solid tumor types
[作者:Chen, CY; Weaver, EA; Khare, R; May, SM; Barry, MA,期刊:Cancer gene therapy, 页码:744-750 , 文章类型: Article,,卷期:2011年18-10]
- Although there are 55 serotypes of adenovirus (Ad) that infect humans, Ad serotype 5 (Ad5) is the most widely studied because of the availability of commercial kits for its genetic manipulation. In fact, engineered Ad 5 ...
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