- Selective Modulation of Nuclear Factor of Activated T-Cell Function in Restenosis by a Potent Bipartite Peptide Inhibitor
[作者：Yu, HX; Bot, I; Sliedregt, K; Xu, XF; Bot, M; van Heiningen, SH; van der Marel, GA; Bennett, MR; Overkleeft, H; van Berkel, TJC; Biessen, EAL,期刊：Circulation Research, 页码：200-200 , 文章类型： Article，,卷期：2012年110-2]
- Rationale: Nuclear factor of activated T-cells (NFAT) is importantly implicated in pathological cardiac remodeling and vascular lesion formation. NFAT functionality is mainly regulated by calcineurin, a Ca2+-dependent mu...
- Induction of Vascular Progenitor Cells From Endothelial Cells Stimulates Coronary Collateral Growth
[作者：Yin, LY; Ohanyan, V; Pung, YF; DeLucia, A; Bailey, E; Enrick, M; Stevanov, K; Kolz, CL; Guarini, G; Chilian, WM,期刊：Circulation Research, 页码：241-241 , 文章类型： Article，,卷期：2012年110-2]
- Rationale: A well-developed coronary collateral circulation improves the morbidity and mortality of patients following an acute coronary occlusion. Although regenerative medicine has great potential in stimulating vascul...
- Regulated Expression and Role of c-Myb in the Cardiovascular-Directed Differentiation of Mouse Embryonic Stem Cells
[作者：Ishida, M; El-Mounayri, O; Kattman, S; Zandstra, P; Sakamoto, H; Ogawa, M; Keller, G; Husain, M,期刊：Circulation Research, 页码：253-253 , 文章类型： Article，,卷期：2012年110-2]
- Rationale: c-myb null (knockout) embryonic stem cells (ESC) can differentiate into cardiomyocytes but not contractile smooth muscle cells (SMC) in embryoid bodies (EB). Objective: To define the role of c-Myb in SMC diffe...
- G(i)-Biased beta(2)AR Signaling Links GRK2 Upregulation to Heart Failure
[作者：Zhu, WZ; Petrashevskaya, N; Ren, SX; Zhao, AZ; Chakir, K; Gao, EH; Chuprun, JK; Wang, YB; Talan, M; Dorn, GW; Lakatta, EG; Koch, WJ; Feldman, AM; Xiao, RP,期刊：Circulation Research, 页码：265-265 , 文章类型： Article，,卷期：2012年110-2]
- Rationale: Phosphorylation of beta(2)-adrenergic receptor (beta(2)AR) by a family of serine/threonine kinases known as G protein-coupled receptor kinase (GRK) and protein kinase A (PKA) is a critical determinant of cardi...
- Adventitial Delivery of an Allogeneic Bone Marrow-Derived Adherent Stem Cell in Acute Myocardial Infarction Phase I Clinical Study
[作者：Penn, MS; Ellis, S; Gandhi, S; Greenbaum, A; Hodes, Z; Mendelsohn, FO; Strasser, D; Ting, AE; Sherman, W,期刊：Circulation Research, 页码：304-304 , 文章类型： Article，,卷期：2012年110-2]
- Rationale: MultiStem is an allogeneic bone marrow-derived adherent adult stem cell product that has shown efficacy in preclinical models of acute myocardial infarction (AMI). In this phase I clinical trial in patients wi...
- miR-29b Participates in Early Aneurysm Development in Marfan Syndrome
[作者：Merk, DR; Chin, JT; Dake, BA; Maegdefessel, L; Miller, MO; Kimura, N; Tsao, PS; Iosef, C; Berry, GJ; Mohr, FW; Spin, JM; Alvira, CM; Robbins, RC; Fischbein, MP,期刊：Circulation Research, 页码：312-312 , 文章类型： Article，,卷期：2012年110-2]
- Rationale: Marfan syndrome (MFS) is a systemic connective tissue disorder notable for the development of aortic root aneurysms and the subsequent life-threatening complications of aortic dissection and rupture. Underlyin...
- Development, Maturation, and Transdifferentiation of Cardiac Sympathetic Nerves
[作者：Kimura, K; Ieda, M; Fukuda, K,期刊：Circulation Research, 页码：325-336 , 文章类型： Review，,卷期：2012年110-2]
- The heart is electrically and mechanically controlled as a syncytium by the autonomic nervous system. The cardiac nervous system comprises the sympathetic, parasympathetic, and sensory nervous systems that together regul...
- Genetic Basis of Atherosclerosis: Insights From Mice and Humans
[作者：Stylianou, IM; Bauer, RC; Reilly, MP; Rader, DJ,期刊：Circulation Research, 页码：337-355 , 文章类型： Review，,卷期：2012年110-2]
- Atherosclerosis is a complex and heritable disease involving multiple cell types and the interactions of many different molecular pathways. The genetic and molecular mechanisms of atherosclerosis have, in part, been eluc...
- Dominant-Negative Control of cAMP-Dependent I-Ks Upregulation in Human Long-QT Syndrome Type 1
[作者：Heijman, J; Spatjens, RLHMG; Seyen, SRM; Lentink, V; Kuijpers, HJH; Boulet, IR; de Windt, LJ; David, M; Volders, PGA,期刊：Circulation Research, 页码：211-211 , 文章类型： Article，,卷期：2012年110-2]
- Rationale: The mutation A341V in the S6 transmembrane segment of KCNQ1, the alpha-subunit of the slowly activating delayed-rectifier K+ (I-Ks) channel, predisposes to a severe long-QT1 syndrome with sympathetic-triggered...
- The Role of Fibroblasts in Complex Fractionated Electrograms During Persistent/Permanent Atrial Fibrillation Implications for Electrogram-Based Catheter Ablation
[作者：Ashihara, T; Haraguchi, R; Nakazawa, K; Namba, T; Ikeda, T; Nakazawa, Y; Ozawa, T; Ito, M; Horie, M; Trayanova, NA,期刊：Circulation Research, 页码：275-275 , 文章类型： Article，,卷期：2012年110-2]
- Rationale: Electrogram-based catheter ablation, targeting complex fractionated atrial electrograms (CFAEs), is empirically known to be effective in halting persistent/permanent atrial fibrillation (AF). However, the mech...
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