- Asymmetric Chromatid Segregation in Cardiac Progenitor Cells Is Enhanced by Pim-1 Kinase
[作者：Sundararaman, B; Avitabile, D; Konstandin, MH; Cottage, CT; Gude, N; Sussman, MA,期刊：Circulation Research, 页码：1169-+ , 文章类型： Article，,卷期：2012年110-9]
- Rationale: Cardiac progenitor cells (CPCs) in the adult heart are used for cell-based treatment of myocardial damage, but factors determining stemness, self-renewal, and lineage commitment are poorly understood. Immortal...
- Substrate- and Isoform-Specific Proteome Stability in Normal and Stressed Cardiac Mitochondria
[作者：Lau, E; Wang, D; Zhang, J; Yu, HX; Lam, MPY; Liang, XB; Zong, N; Kim, TY; Ping, PP,期刊：Circulation Research, 页码：1174-+ , 文章类型： Article，,卷期：2012年110-9]
- Rationale: Mitochondrial protein homeostasis is an essential component of the functions and oxidative stress responses of the heart. Objective: To determine the specificity and efficiency of proteome turnover of the card...
- PAR-2 Inhibition Reverses Experimental Pulmonary Hypertension
[作者：Kwapiszewska, G; Markart, P; Dahal, BK; Kojonazarov, B; Marsh, LM; Schermuly, RT; Taube, C; Meinhardt, A; Ghofrani, HA; Steinhoff, M; Seeger, W; Preissner, KT; Olschewski, A; Weissmann, N; Wygrecka, M,期刊：Circulation Research, 页码：1179-+ , 文章类型： Article，,卷期：2012年110-9]
- Rationale: A hallmark of the vascular remodeling process underlying pulmonary hypertension (PH) is the aberrant proliferation and migration of pulmonary arterial smooth muscle cells (PASMC). Accumulating evidence suggest...
- AMP-Activated Protein Kinase Phosphorylates Cardiac Troponin I and Alters Contractility of Murine Ventricular Myocytes
[作者：Oliveira, SM; Zhang, YH; Solis, RS; Isackson, H; Bellahcene, M; Yavari, A; Pinter, K; Davies, JK; Ge, Y; Ashrafian, H; Walker, JW; Carling, D; Watkins, H; Casadei, B; Redwood, C,期刊：Circulation Research, 页码：1192-1201 , 文章类型： Article，,卷期：2012年110-9]
- Rationale: AMP-activated protein kinase (AMPK) is an important regulator of energy balance and signaling in the heart. Mutations affecting the regulatory gamma 2 subunit have been shown to cause an essentially cardiac-re...
- Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis
[作者：Langer, HF; Choi, EY; Zhou, H; Schleicher, R; Chung, KJ; Tang, ZS; Gobel, K; Bdeir, K; Chatzigeorgiou, A; Wong, C; Bhatia, S; Kruhlak, MJ; Rose, JW; Burns, JB; Hill, KE; Qu, HC; Zhang, YQ; Lehrmann, E; Becker, KG; Wang, YM; Simon, DI; Nieswandt, B; Lambris, JD; Li, XR; Meuth, SG; Kubes, P; Chavakis, T,期刊：Circulation Research, 页码：1202-+ , 文章类型： Article，,卷期：2012年110-9]
- Rationale: Multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE), are inflammatory disorders of the central nervous system (CNS). The function of platelets in inflammatory and autoi...
- Uncoupling Protein-2 Protects Endothelial Function in Diet-Induced Obese Mice
[作者：Tian, XY; Wong, WT; Xu, AM; Lu, Y; Zhang, Y; Wang, L; Cheang, WS; Wang, Y; Yao, XQ; Huang, Y,期刊：Circulation Research, 页码：1211-+ , 文章类型： Article，,卷期：2012年110-9]
- Rationale: Previous studies indicate uncoupling protein-2 (UCP2) as an antioxidant defense against endothelial dysfunction in hypertension. UCP2 also regulates insulin secretion and action. However, the role of UCP2 in e...
- Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase
[作者：Schroder, K; Zhang, M; Benkhoff, S; Mieth, A; Pliquett, R; Kosowski, J; Kruse, C; Luedike, P; Michaelis, UR; Weissmann, N; Dimmeler, S; Shah, AM; Brandes, RP,期刊：Circulation Research, 页码：1217-+ , 文章类型： Article，,卷期：2012年110-9]
- Rationale: The function of Nox4, a source of vascular H2O2, is unknown. Other Nox proteins were identified as mediators of endothelial dysfunction. Objective: We determined the function of Nox4 in situations of increased...
- Telomeres and Mitochondria in the Aging Heart
[作者：Moslehi, J; DePinho, RA; Sahin, E,期刊：Circulation Research, 页码：1226-1237 , 文章类型： Review，,卷期：2012年110-9]
- Studies in humans and in mice have highlighted the importance of short telomeres and impaired mitochondrial function in driving age-related functional decline in the heart. Although telomere and mitochondrial dysfunction...
- Effects of Aging on Angiogenesis
[作者：Lahteenvuo, J; Rosenzweig, A,期刊：Circulation Research, 页码：1252-1263 , 文章类型： Review，,卷期：2012年110-9]
- Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of both cardiovascular diseases and their adverse ...
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