- RNAP subunits F/E (RPB4/7) are stably associated with archaeal RNA polymerase: using fluorescence anisotropy to monitor RNAP assembly in vitro
[作者:Grohmann, D; Hirtreiter, A; Werner, F,期刊:Biochemical Journal, 页码:339-343 , 文章类型: Article,,卷期:2009年421-Part 3]
- Archaeal and eukaryotic RNAPs (DNA-dependent RNA polymerases) are complex multi-subunit enzymes. Two of the subunits, F and E, which together form the F/E complex, have been hypothesized to associate with RNAP in a rever...
- Dual acylation is required for trafficking of growth-associated protein-43 (GAP-43) to endosomal recycling compartment via an Arf6-associated endocytic vesicular pathway
[作者:Trenchi, A; Gomez, GA; Daniott, JL,期刊:Biochemical Journal, 页码:357-369 , 文章类型: Article,,卷期:2009年421-Part 3]
- GAP-43 (growth-associated protein-43) is it dually palmitoylated protein, at cysteine residues at positions 3 and 4, that mostly localizes in plasma membrane both in neural and non-neural cells. In the present study, we ...
- Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion
[作者:Pound, LD; Sarkar, SA; Benninger, RKP; Wang, YD; Suwanichkul, A; Shadoan, MK; Printz, RL; Oeser, JK; Lee, CE; Piston, DW; McGuinness, OP; Hutton, JC; Powell, DR; O'Brien, RM,期刊:Biochemical Journal, 页码:371-376 , 文章类型: Article,,卷期:2009年421-Part 3]
- The Slc30a8 gene encodes the islet-specific zinc transporter ZnT-8, which provides zinc for insulin-hexamer formation. Polymorphic variants in amino acid residue 325 of human ZnT-8 are associated with altered susceptibil...
- Dynasore inhibits removal of wild-type and Delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) from the plasma membrane
[作者:Young, A; Gentzsch, M; Abban, CY; Jia, Y; Meneses, PI; Bridges, RJ; Bradbury, NA,期刊:Biochemical Journal, 页码:377-385 , 文章类型: Article,,卷期:2009年421-Part 3]
- Dynasore, a small molecule inhibitor of dynamin, Was used to probe the role of dynamin in the endocytosis of wild-type and mutant CFTR (cystic fibrosis transmembrane conductance regulator). Internalization of both wild-t...
- Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2
[作者:Cozza, G; Mazzorana, M; Papinutto, E; Bain, J; Elliott, M; Di Maira, G; Gianoncelli, A; Pagano, MA; Sarno, S; Ruzzene, M; Battistutta, R; Meggio, F; Moro, S; Zagotto, G; Pinna, LA,期刊:Biochemical Journal, 页码:387-395 , 文章类型: Article,,卷期:2009年421-Part 3]
- Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a moderately potent and poorly selective inhibitor of protein kinase CK2, one of the most pleiotropic serine/threonine protein kinases, implicated in neoplasia and in o...
- PKC epsilon has an alcohol-binding site in its second cysteine-rich regulatory domain
[作者:Das, J; Pany, S; Rahman, GM; Slater, SJ,期刊:Biochemical Journal, 页码:405-413 , 文章类型: Article,,卷期:2009年421-Part 3]
- Alcohols regulate the expression and function of PKC (protein kinase C), and it has been proposed that ail alcohol-binding site is present in PKC alpha in its C1 domain, which consists of two cysteine-rich subdomains, C1...
- Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide
[作者:Cerf, E; Sarroukh, R; Tamamizu-Kato, S; Breydo, L; Derclaye, S; Dufrene, YF; Narayanaswami, V; Goormaghtigh, E; Ruysschaert, JM; Raussens, V,期刊:Biochemical Journal, 页码:415-423 , 文章类型: Article,,卷期:2009年421-Part 3]
- AD (Alzheimer's disease) is linked to A beta (amyloid beta-peptide) misfolding. Studies demonstrate that the level Of Soluble A beta oligomeric forms correlates better with the progression of the disease than the level o...
- Artificial beta-defensin based on a minimal defensin template
[作者:Antcheva, N; Morgera, F; Creatti, L; Vaccari, L; Pag, U; Pacor, S; Shai, Y; Sahl, HG; Tossi, A,期刊:Biochemical Journal, 页码:435-447 , 文章类型: Article,,卷期:2009年421-Part 3]
- We have designed and chemically synthesized all artificial beta-defensin based on a minimal template derived from the comparative analysis of over 80 naturally occurring Sequences. This molecule has the disulfide-bridged...
- Glycyrrhizin, the main active compound in liquorice, attenuates pro-inflammatory responses by interfering with membrane-dependent receptor signalling
[作者:Schrofelbauer, B; Raffetseder, J; Hauner, M; Wolkerstorfer, A; Ernst, W; Szolar, OHJ,期刊:Biochemical Journal, 页码:473-482 , 文章类型: Article,,卷期:2009年421-Part 3]
- The triterpene glycoside glycyrrhizin is the main active compound in liquorice. It is used as it herbal medicine owing to its anticancer, antiviral and anti-inflammatory properties. Its mode of action, however, remains w...
- Polyamine catabolism and disease
[作者:Casero, RA; Pegg, AE,期刊:Biochemical Journal, 页码:323-338 , 文章类型: Review,,卷期:2009年421-Part 3]
- In addition to polyamine homoeostasis, it has become increasingly clear that polyamine catabolism call play a dominant role in drug response, apoptosis and the response 10 stressful, and contribute to the aetiology of se...
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