- Efficient revascularization by VEGF administration via heparin-functionalized nanoparticle-fibrin complex
[作者:Chung, YI; Kim, SK; Lee, YK; Park, SJ; Cho, KO; Yuk, SH; Tae, G; Kim, YH,期刊:Journal of controlled release, 页码:282-289 , 文章类型: Article,,卷期:2010年143-3]
- We investigated the angiogenic bioactivity and therapeutic angiogenic effect of vascular endothelial growth factor (VEGF) administration by the heparin-functionalized nanoparticle-fibrin gel complex. The markedly increas...
- Effects of pluronic and doxorubicin on drug uptake, cellular metabolism, apoptosis and tumor inhibition in animal models of MDR cancers
[作者:Batrakova, EV; Li, S; Brynskikh, AM; Sharma, AK; Li, YL; Boska, M; Gong, N; Mosley, RL; Alakhov, VY; Gendelman, HE; Kabanov, AV,期刊:Journal of controlled release, 页码:290-301 , 文章类型: Article,,卷期:2010年143-3]
- Cancer chemotherapy is believed to be impeded by multidrug resistance (MDR). Pluronic (triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), PEO-b-PPO-b-PEO) were previously shown to sensitiz...
- Structural requirements of penetratin absorption enhancement efficiency for insulin delivery
[作者:Khafagy, ES; Morishita, M; Ida, N; Nishio, R; Isowa, K; Takayama, K,期刊:Journal of controlled release, 页码:302-310 , 文章类型: Article,,卷期:2010年143-3]
- Penetratin, a 16-residue peptide, is used widely as a highly efficient delivery carrier for a wide range of poorly permeable therapeutic cargoes. The crucial structural features of penetratin remain unclear, as demonstra...
- Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: Programmed endosomal escape and dissociation
[作者:Akita, H; Kogure, K; Moriguchi, R; Nakamura, Y; Higashi, T; Nakamura, T; Serada, S; Fujimoto, M; Naka, T; Futaki, S; Harashima, H,期刊:Journal of controlled release, 页码:311-317 , 文章类型: Article,,卷期:2010年143-3]
- We previously developed octaarginine (R8)-modified lipid envelope-type nanoparticles for siRNA delivery (R8-MEND). Herein, we report on their ex vivo siRNA delivery to primary mouse bone marrow-derived dendritic cells (B...
- Insights in cellular uptake mechanisms of pDNA-polycationic amphiphilic cyclodextrin nanoparticles (CDplexes)
[作者:Diaz-Moscoso, A; Vercauteren, D; Rejman, J; Benito, JM; Mellet, CO; De Smedt, SC; Fernandez, JMG,期刊:Journal of controlled release, 页码:318-325 , 文章类型: Article,,卷期:2010年143-3]
- It is generally recognized that the major obstacle to efficient gene delivery is cellular internalization and endosomal escape of the DNA. Recently, we have developed a modular strategy for the preparation of well-define...
- Novel reducible linear L-lysine-modified copolymers as efficient nonviral vectors
[作者:Nounou, MI; Emmanouil, K; Chung, S; Pham, T; Lu, ZY; Bikram, M,期刊:Journal of controlled release, 页码:326-334 , 文章类型: Article,,卷期:2010年143-3]
- The development of biodegradable gene delivery systems with high transfection efficiencies is paramount to the clinical translation of nonviral gene carriers. Therefore, to produce a biocompatible, reducible, effective a...
- Characterization of gene expression regulation using D-RECS polymer by enzymatic reaction for an effective design of enzyme-responsive gene regulator
[作者:Sato, YT; Kawamura, K; Niidome, T; Katayama, Y,期刊:Journal of controlled release, 页码:344-349 , 文章类型: Article,,卷期:2010年143-3]
- The development of targeted gene delivery systems has attracted much attention. Nevertheless, target cell-specific gene delivery has not been realized. However, if gene expression can be regulated with a gene carrier, th...
- Targeted gene delivery into peripheral sensorial neurons mediated by self-assembled vectors composed of poly(ethylene imine) and tetanus toxin fragment c
[作者:Oliveira, H; Fernandez, R; Pires, LR; Martins, MCL; Simoes, S; Barbosa, MA; Pego, AP,期刊:Journal of controlled release, 页码:350-358 , 文章类型: Article,,卷期:2010年143-3]
- A simple, safe and efficient system that can specifically transfect peripheral sensorial neurons can bring new answers to address peripheral neuropathies. A multi-component non-viral gene delivery vector targeted to peri...
- An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles
[作者:Simovic, S; Hui, H; Song, YM; Davey, AK; Rades, T; Prestidge, CA,期刊:Journal of controlled release, 页码:367-373 , 文章类型: Article,,卷期:2010年143-3]
- We report on a porous silica-lipid hybrid microcapsule (SLH) oral delivery system for indomethacin fabricated from Pickering emulsion templates, where the drug forms an electrostatic complex with cationic lipid present i...
- The effect of surface functionalization of PLGA nanoparticles by heparin- or chitosan-conjugated Pluronic on tumor targeting
[作者:Chung, YI; Kim, JC; Kim, YH; Tae, G; Lee, SY; Kim, K; Kwon, IC,期刊:Journal of controlled release, 页码:374-382 , 文章类型: Article,,卷期:2010年143-3]
- The poly (lactide-co-glycolide) (PLGA)-based nanoparticles, coated by the heparin- or chitosan-Pluronic conjugate, were used to improve a relatively low tumor-targeting efficiency of the bare PLGA nanoparticles. The prep...
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