- Site-specific release of nascent chains from ribosomes at a sense codon
[作者:Doronina, VA; Wu, C; de Felipe, P; Sachs, MS; Ryan, MD; Brown, JD,期刊:Molecular and Cellular Biology, 页码:4227-4239 , 文章类型: Article,,卷期:2008年28-13]
- 2A oligopeptides are autonomous elements containing a D(V/I)EXNPGP motif at the C terminus. Protein synthesis from an open reading frame containing an internal 2A coding sequence yields two separate polypeptides, corresp...
- Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and sp1
[作者:Li, Y; Kimura, T; Huyck, RW; Laity, JH; Andrews, GK,期刊:Molecular and Cellular Biology, 页码:4275-4284 , 文章类型: Article,,卷期:2008年28-13]
- Herein, the mechanisms of transactivation of gene expression by mouse metal response element-binding transcription factor 1 (MTF-1) were investigated. Evidence obtained from coimmunoprecipitation assays revealed that exp...
- Cancer cell-derived clusterin modulates the phosphatidylinositol 3 '-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation
[作者:Jo, H; Jia, YH; Subramanian, KK; Hattori, H; Luo, HBR,期刊:Molecular and Cellular Biology, 页码:4285-4299 , 文章类型: Article,,卷期:2008年28-13]
- Cancer cells in their respective microenvironments must endure various growth-constraining stresses. Under these conditions, the cancer cell-derived factors are thought to modulate the signaling pathways between cell gro...
- Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay
[作者:Saltzman, AL; Kim, YK; Pan, Q; Fagnani, MM; Maquat, LE; Blencowe, BJ,期刊:Molecular and Cellular Biology, 页码:4320-4330 , 文章类型: Article,,卷期:2008年28-13]
- Alternative splicing (AS) can regulate gene expression by introducing premature termination codons (PTCs) into spliced mRNA that subsequently elicit transcript degradation by the nonsense-mediated mRNA decay (NMD) pathwa...
- Involvement of importin-4 in the transport of transition protein 2 into the spermatid nucleus
[作者:Pradeepa, MM; Manjunatha, S; Sathish, V; Agrawal, S; Rao, MRS,期刊:Molecular and Cellular Biology, 页码:4331-4341 , 文章类型: Article,,卷期:2008年28-13]
- Mammalian spermiogenesis is characterized by a unique chromatin-remodeling process in which histones are replaced by transition protein 1 (TP1), TP2, and TP4, which are further replaced by protamines. We showed previousl...
- The assembly pathway of the mitochondrial carrier translocase involves four preprotein translocases
[作者:Wagner, K; Gebert, N; Guiard, B; Brandner, K; Truscott, KN; Wiedemann, N; Pfanner, N; Rehling, P,期刊:Molecular and Cellular Biology, 页码:4251-4260 , 文章类型: Article,,卷期:2008年28-13]
- The mitochondrial inner membrane contains preprotein translocases that mediate insertion of hydrophobic proteins. Little is known about how the individual components of these inner membrane preprotein translocases combin...
- GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA(+) ATPase CDC-48
[作者:Caruso, ME; Jenna, S; Bouchecareilh, M; Baillie, DL; Boismenu, D; Halawani, D; Latterich, M; Chevet, E,期刊:Molecular and Cellular Biology, 页码:4261-4274 , 文章类型: Article,,卷期:2008年28-13]
- When endoplasmic reticulum (ER) homeostasis is perturbed, an adaptive mechanism is triggered and named the unfolded protein response (UPR). Thus far, three known UPR signaling branches (IRE-1, PERK, and ATE-6) mediate th...
- Targeting the GA binding protein beta 1L isoform does not perturb lymphocyte development and function
[作者:Xue, HH; Jing, XF; Bollenbacher-Reilley, J; Zhao, DM; Haring, JS; Yang, BL; Liu, CY; Bishop, GA; Harty, JT; Leonard, WJ,期刊:Molecular and Cellular Biology, 页码:4300-4309 , 文章类型: Article,,卷期:2008年28-13]
- GA binding protein (GASP) is a ubiquitously expressed Ets family transcription factor that consists of two subunits, GABP alpha and GABP beta. GABP alpha binds to DNA, and GABP beta heterodimerizes with GABP alpha and po...
- Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair
[作者:Guo, ZG; Qian, LM; Liu, R; Dai, HF; Zhou, MA; Zheng, L; Shen, BH,期刊:Molecular and Cellular Biology, 页码:4310-4319 , 文章类型: Article,,卷期:2008年28-13]
- Despite the wealth of information available on the biochemical functions and our recent findings of its roles in genome stability and cancer avoidance of the structure-specific flap endonuclease 1 (FEN1), its cellular co...
- Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109
[作者:Fillingham, J; Recht, J; Silva, AC; Suter, B; Emili, A; Stagljar, I; Krogan, NJ; Allis, CD; Keogh, MC; Greenblatt, JF,期刊:Molecular and Cellular Biology, 页码:4342-4353 , 文章类型: Article,,卷期:2008年28-13]
- Acetylation of Saccharomyces cerevisiae histone H3 on K56 by the histone acetyltransferase (HAT) Rtt109 is important for repairing replication-associated lesions. Rtt109 purifies from yeast in complex with the histone ch...
- Electrostatic interactions positively regulate K-ras nanocluster formation and function
[作者:Plowman, SJ; Ariotti, N; Goodall, A; Parton, RG; Hancock, JF,期刊:Molecular and Cellular Biology, 页码:4377-4385 , 文章类型: Article,,卷期:2008年28-13]
- The organization of Ras proteins into plasma membrane nanoclusters is essential for high-fidelity signal transmission, but whether the nanoscale enviroments of different Ras nanoclusters regulate effector interactions is...
- A T-to-G transversion at nucleotide-567 upstream of HBG2 in a GATA-1 binding motif is associated with elevated hemoglobin F
[作者:Chen, ZY; Luo, HY; Basran, RK; Hsu, TH; Mang, DWH; Nuntakam, L; Rosenfield, CG; Patrinos, GP; Hardison, RC; Steinberg, MH; Chui, DHK,期刊:Molecular and Cellular Biology, 页码:4386-4393 , 文章类型: Article,,卷期:2008年28-13]
- Increased fetal hemoglobin (Hb F; alpha(2)gamma(2)) production in adults can ameliorate the clinical severity of sickle cell disease and beta-thalassemia major. Thus, understanding the regulation of gamma-globin gene exp...
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